Laurie A. Boyer investigates the gene regulatory mechanisms that drive heart development and regeneration using embryonic stem cells and mouse models.
Eliezer Calo studies how cells build ribosomes and how dysfunction in ribosome biogenesis and function leads to tissue-specific developmental disorders and cancer.
Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore cancer treatment and vaccine development.
Leonard P. Guarente looks at mammal, mouse, and human brains to understand the genetic underpinning of aging and age-related diseases like Alzheimer’s.
Piyush Gupta investigates how alterations in cellular differentiation drive cancer malignancy, focusing on the mechanisms that underlie multidrug resistance and invasive progression.
Michael T. Hemann uses mouse models to combat cancers resistant to chemotherapy.
David Housman studies the biological underpinnings of diseases like Huntington’s, cancer, and cardiovascular disease.
Rudolf Jaenisch uses pluripotent cells (ES and iPS cells) to study the genetic and epigenetic basis of human diseases such as Parkinson’s, Alzheimer’s, autism and cancer.
Ankur Jain investigates the role of RNA self-assembly in cellular organization and neurodegenerative disease.
Monty Krieger studies cell surface receptors and cholesterol and their impact on normal physiology and diseases, such as heart disease and infertility.
Eric S. Lander is interested in every aspect of the human genome and its application to medicine.
Associate Dept. Head
Jacqueline Lees develops mouse and zebrafish models, identifying the molecular pathways leading to tumor formation.
Harvey F. Lodish studies the development of red blood cells and the use of modified red cells for the introduction of novel therapeutics into the human body, as well as the development of brown and white fat cells.
David C. Page examines the genetic differences between males and females — and how these play out in disease, development, and evolution.
Edward Scolnick has provided critical insights into the genetic underpinnings of a variety of psychiatric disorders, including bipolar disorder, schizophrenia, and autism.
Hazel Sive studies fundamental mechanisms underlying vertebrate face and brain formation, as well as the molecular underpinnings for neurodevelopmental disorders.
Stefani Spranger studies how the body’s immune system interacts with growing tumors to harness the immune response to fight cancer.
Susumu Tonegawa investigates the biological underpinnings of learning and memory in rodents.
Jing-Ke Weng studies metabolic evolution in plants and explores the remarkable plant chemodiversity for new commodity chemicals and medicines.
Omer H. Yilmaz explores the impact of dietary interventions on stem cells, the immune system, and cancer within the intestine.
Richard A. Young explores how and why gene expression differs in healthy versus diseased cells.