Omer H. Yilmaz

Omer H. Yilmaz

Eisen and Chang Career Development Assistant Professor

Omer H. Yilmaz explores the impact of dietary interventions on stem cells, the immune system, and cancer within the intestine.

617-324-7633

Phone

76-553G

Office

617-253-3016

Assistant Phone

Education

  • PhD, 2008, University of Michigan; MD, 2008, University of Michigan Medical School
  • BS, 1999, Biochemistry and Physics, University of Michigan

Research Summary

The adult intestine is maintained by stem cells that require a cellular neighborhood, or niche, consisting in part of Paneth cells. Our laboratory will investigate the molecular mechanisms of how intestinal stem cells and their Paneth cell niche respond to diverse diets to coordinate intestinal regeneration with organismal physiology and its impact on the formation and growth of intestinal cancers.  By better understanding how intestinal stem cells adapt to diverse diets, we hope to identify and develop new strategies that prevent and reduce the growth of cancers involving the intestinal tract that includes the small intestine, colon, and rectum.

Awards

  • AAAS Martin and Rose Wachtel Cancer Research Award, 2018
  • Pew-Stewart Trust Scholar, 2016-2020
  • Sidney Kimmel Scholar, 2016-2020
  • V Foundation Scholar, 2014-2017
  • Harold M. Weintraub Award, 2007

Key Publications

  1. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Roper, J, Tammela, T, Cetinbas, NM, Akkad, A, Roghanian, A, Rickelt, S, Almeqdadi, M, Wu, K, Oberli, MA, Sánchez-Rivera, FJ et al.. 2017. Nat. Biotechnol. 35, 569-576.
    doi: 10.1038/nbt.3836PMID:28459449
  2. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Beyaz, S, Mana, MD, Roper, J, Kedrin, D, Saadatpour, A, Hong, SJ, Bauer-Rowe, KE, Xifaras, ME, Akkad, A, Arias, E et al.. 2016. Nature 531, 53-8.
    doi: 10.1038/nature17173PMID:26935695
  3. Dietary and metabolic control of stem cell function in physiology and cancer. Mihaylova, MM, Sabatini, DM, Yilmaz, ÖH. 2014. Cell Stem Cell 14, 292-305.
    doi: 10.1016/j.stem.2014.02.008PMID:24607404
  4. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Yilmaz, ÖH, Katajisto, P, Lamming, DW, Gültekin, Y, Bauer-Rowe, KE, Sengupta, S, Birsoy, K, Dursun, A, Yilmaz, VO, Selig, M et al.. 2012. Nature 486, 490-5.
    doi: 10.1038/nature11163PMID:22722868
  5. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Yilmaz, OH, Valdez, R, Theisen, BK, Guo, W, Ferguson, DO, Wu, H, Morrison, SJ. 2006. Nature 441, 475-82.
    doi: 10.1038/nature04703PMID:16598206

Recent Publications

  1. Gut organoids: mini-tissues in culture to study intestinal physiology and disease. Almeqdadi, M, Mana, MD, Roper, J, Yilmaz, ÖH. 2019. Am. J. Physiol., Cell Physiol. 317, C405-C419.
    doi: 10.1152/ajpcell.00300.2017PMID:31216420
  2. CRAD as a cytoskeletal tumour suppressor. Eng, G, Braverman, J, Yilmaz, ÖH. 2018. Nat. Cell Biol. 20, 1232-1233.
    doi: 10.1038/s41556-018-0225-xPMID:30361696
  3. Dietary regulation of the origins of cancer. Yilmaz, ÖH. 2018. Sci Transl Med 10, .
    doi: 10.1126/scitranslmed.aat8285PMID:30089636
  4. Nutritional Regulation of Intestinal Stem Cells. Alonso, S, Yilmaz, ÖH. 2018. Annu. Rev. Nutr. 38, 273-301.
    doi: 10.1146/annurev-nutr-082117-051644PMID:29799767
  5. From 3D Organoids back to 2D Enteroids. Braverman, J, Yilmaz, ÖH. 2018. Dev. Cell 44, 533-534.
    doi: 10.1016/j.devcel.2018.02.016PMID:29533766
  6. Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Roper, J, Tammela, T, Akkad, A, Almeqdadi, M, Santos, SB, Jacks, T, Yilmaz, ÖH. 2018. Nat Protoc 13, 217-234.
    doi: 10.1038/nprot.2017.136PMID:29300388
  7. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Roper, J, Tammela, T, Cetinbas, NM, Akkad, A, Roghanian, A, Rickelt, S, Almeqdadi, M, Wu, K, Oberli, MA, Sánchez-Rivera, FJ et al.. 2017. Nat. Biotechnol. 35, 569-576.
    doi: 10.1038/nbt.3836PMID:28459449
  8. Starving leukemia to induce differentiation. Cheng, CW, Yilmaz, ÖH. 2017. Nat. Med. 23, 14-15.
    doi: 10.1038/nm.4259PMID:28060803
  9. Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ Pathway. Beyaz, S, Yilmaz, ÖH. 2016. Clin. Cancer Res. 22, 5636-5641.
    doi: 10.1158/1078-0432.CCR-16-0775PMID:27702819
  10. IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy. Cheng, CW, Yilmaz, ÖH. 2015. Cell Stem Cell 17, 379-80.
    doi: 10.1016/j.stem.2015.09.008PMID:26431180
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