Jianzhu Chen

Jianzhu Chen

Professor of Biology; Singapore Research Professor

Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore cancer treatment and vaccine development.





Ryan Hayman



Assistant Phone


PhD 1990, Stanford University

Research Summary 

We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.


  • American Association for the Advancement of Science, Fellow, 2012

Recent Publications

  1. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. Ye, W, Chew, M, Hou, J, Lai, F, Leopold, SJ, Loo, HL, Ghose, A, Dutta, AK, Chen, Q, Ooi, EE et al.. 2018. PLoS Pathog. 14, e1007298.
    doi: 10.1371/journal.ppat.1007298PMID:30286211
  2. Culture and Differentiation of Lung Bronchiolar Epithelial Cells In Vitro. Zheng, D, Chen, J. 2018. Methods Mol. Biol. 1817, 33-40.
    doi: 10.1007/978-1-4939-8600-2_4PMID:29959700
  3. Antibiotics induce polarization of pleural macrophages to M2-like phenotype in patients with tuberculous pleuritis. Wang, S, Zhang, J, Sui, L, Xu, H, Piao, Q, Liu, Y, Qu, X, Sun, Y, Song, L, Li, D et al.. 2017. Sci Rep 7, 14982.
    doi: 10.1038/s41598-017-14808-9PMID:29101376
  4. Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. Costa, VV, Ye, W, Chen, Q, Teixeira, MM, Preiser, P, Ooi, EE, Chen, J. 2017. MBio 8, .
    doi: 10.1128/mBio.00741-17PMID:28765218
  5. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro. Zheng, D, Soh, BS, Yin, L, Hu, G, Chen, Q, Choi, H, Han, J, Chow, VT, Chen, J. 2017. Sci Rep 7, 41661.
    doi: 10.1038/srep41661PMID:28128362
  6. Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling. Drake, A, Kaur, M, Iliopoulou, BP, Phennicie, R, Hanson, A, Chen, J. 2016. PLoS ONE 11, e0166280.
    doi: 10.1371/journal.pone.0166280PMID:27855183
  7. B Cells Promote Pancreatic Tumorigenesis. Roghanian, A, Fraser, C, Kleyman, M, Chen, J. 2016. Cancer Discov 6, 230-2.
    doi: 10.1158/2159-8290.CD-16-0100PMID:26951836
  8. Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human. Chen, Q, Ye, W, Jian Tan, W, Mei Yong, KS, Liu, M, Qi Tan, S, Loh, E, Te Chang, K, Chye Tan, T, Preiser, PR et al.. 2015. Sci Rep 5, 15118.
    doi: 10.1038/srep15118PMID:26456148
  9. Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells. Li, Y, Shen, C, Zhu, B, Shi, F, Eisen, HN, Chen, J. 2015. J. Immunol. 195, 1591-8.
    doi: 10.4049/jimmunol.1500451PMID:26163589
  10. CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate. Bak, SP, Barnkob, MS, Wittrup, KD, Chen, J. 2013. Cancer Immunol Res 1, 393-401.
    doi: 10.1158/2326-6066.CIR-13-0109PMID:24778132
More Publications
Photo credit: Kelsey Montgomery