Jianzhu Chen

Jianzhu Chen

Professor of Biology; Singapore Research Professor

Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore treatment and prevention for cancer, as well as metabolic and infectious diseases.

617-258-6173

Phone

76-261

Office

Ryan Hayman

Assistant

617-253-0796

Assistant Phone

Education

  • PhD, 1990, Stanford University
  • BS, 1982, Biology, Wuhan University

Research Summary 

We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.

Awards

  • American Association for the Advancement of Science, Fellow, 2012

Key Publications

  1. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. Bidet, K, Ho, V, Chu, CW, Naim, ANH, Thazin, K, Chan, KR, Low, JGH, Choy, MM, Wong, LH, Florez de Sessions, P et al.. 2019. NPJ Vaccines 4, 27.
    doi: 10.1038/s41541-019-0119-3PMID:31285858
  2. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu, G, Dong, T, Wang, S, Jing, H, Chen, J. 2019. EBioMedicine 45, 563-577.
    doi: 10.1016/j.ebiom.2019.06.039PMID:31278070
  3. Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice. Kaur, M, Drake, AC, Hu, G, Rudnick, S, Chen, Q, Phennicie, R, Attar, R, Nemeth, J, Gaudet, F, Chen, J et al.. 2019. J Immunol 202, 1885-1894.
    doi: 10.4049/jimmunol.1800366PMID:30710044
  4. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Chen, H, Cho, KS, Vu, THK, Shen, CH, Kaur, M, Chen, G, Mathew, R, McHam, ML, Fazelat, A, Lashkari, K et al.. 2018. Nat Commun 9, 3209.
    doi: 10.1038/s41467-018-05681-9PMID:30097565
  5. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
    doi: 10.1016/j.cell.2013.12.041PMID:24485462

Recent Publications

  1. Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics. Yong, KSM, Her, Z, Tan, SY, Tan, WWS, Liu, M, Lai, F, Heng, SM, Fan, Y, Chang, KTE, Wang, CI et al.. 2020. Front Immunol 11, 553362.
    doi: 10.3389/fimmu.2020.553362PMID:33193321
  2. Successive Immunization With Epitope-Decreasing Dengue Antigens Induced Conservative Anti-Dengue Immune Responses. Hou, J, Ye, W, Loo, HL, Wong, LH, Chen, J. 2020. Front Immunol 11, 585133.
    doi: 10.3389/fimmu.2020.585133PMID:33101316
  3. CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Xie, G, Ivica, NA, Jia, B, Li, Y, Dong, H, Liang, Y, Brown, D, Rizwan, R, Chen, J. 2020. Nat Biomed Eng , .
    doi: 10.1038/s41551-020-00625-5PMID:33046866
  4. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li, Y, Ivica, NA, Dong, T, Papageorgiou, DP, He, Y, Brown, DR, Kleyman, M, Hu, G, Chen, WW, Sullivan, LB et al.. 2020. Nat Commun 11, 4837.
    doi: 10.1038/s41467-020-18607-1PMID:32973183
  5. LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. Yeboah, M, Papagregoriou, C, Jones, DC, Chan, HTC, Hu, G, McPartlan, JS, Schiött, T, Mattson, U, Mockridge, CI, Tornberg, UC et al.. 2020. JCI Insight 5, .
    doi: 10.1172/jci.insight.141593PMID:32870822
  6. CAR-NK cells: A promising cellular immunotherapy for cancer. Xie, G, Dong, H, Liang, Y, Ham, JD, Rizwan, R, Chen, J. 2020. EBioMedicine 59, 102975.
    doi: 10.1016/j.ebiom.2020.102975PMID:32853984
  7. Corrigendum: IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation. Liu, X, Li, F, Niu, H, Ma, L, Chen, J, Zhang, Y, Peng, L, Gan, C, Ma, X, Zhu, B et al.. 2020. Front Immunol 11, 1671.
    doi: 10.3389/fimmu.2020.01671PMID:32849579
  8. Microfluidic label-free bioprocessing of human reticulocytes from erythroid culture. Zeming, KK, Sato, Y, Yin, L, Huang, NJ, Wong, LH, Loo, HL, Lim, YB, Lim, CT, Chen, J, Preiser, PR et al.. 2020. Lab Chip 20, 3445-3460.
    doi: 10.1039/c9lc01128ePMID:32793940
  9. Sequential immunization induces strong and broad immunity against all four dengue virus serotypes. Hou, J, Shrivastava, S, Loo, HL, Wong, LH, Ooi, EE, Chen, J. 2020. NPJ Vaccines 5, 68.
    doi: 10.1038/s41541-020-00216-0PMID:32728482
  10. Rapid activation of distinct members of multigene families in Plasmodium spp. Omelianczyk, RI, Loh, HP, Chew, M, Hoo, R, Baumgarten, S, Renia, L, Chen, J, Preiser, PR. 2020. Commun Biol 3, 351.
    doi: 10.1038/s42003-020-1081-3PMID:32620892
More Publications
Photo credit: Kelsey Montgomery