Jianzhu Chen

Jianzhu Chen

Professor of Biology; Singapore Research Professor

Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore treatment and prevention for cancer, as well as metabolic and infectious diseases.

617-258-6173

Phone

76-261

Office

Ryan Hayman

Assistant

617-253-0796

Assistant Phone

Education

  • PhD, 1990, Stanford University
  • BS, 1982, Biology, Wuhan University

Research Summary 

We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.

Awards

  • American Association for the Advancement of Science, Fellow, 2012

Key Publications

  1. High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming. Hu, G, Su, Y, Kang, BH, Fan, Z, Dong, T, Brown, DR, Cheah, J, Wittrup, KD, Chen, J. 2021. Nat Commun 12, 773.
    doi: 10.1038/s41467-021-21066-xPMID:33536439
  2. CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Xie, G, Ivica, NA, Jia, B, Li, Y, Dong, H, Liang, Y, Brown, D, Romee, R, Chen, J. 2021. Nat Biomed Eng 5, 399-413.
    doi: 10.1038/s41551-020-00625-5PMID:33046866
  3. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li, Y, Ivica, NA, Dong, T, Papageorgiou, DP, He, Y, Brown, DR, Kleyman, M, Hu, G, Chen, WW, Sullivan, LB et al.. 2020. Nat Commun 11, 4837.
    doi: 10.1038/s41467-020-18607-1PMID:32973183
  4. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu, G, Dong, T, Wang, S, Jing, H, Chen, J. 2019. EBioMedicine 45, 563-577.
    doi: 10.1016/j.ebiom.2019.06.039PMID:31278070
  5. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
    doi: 10.1016/j.cell.2013.12.041PMID:24485462

Recent Publications

  1. In situ cancer vaccination using lipidoid nanoparticles. Chen, J, Qiu, M, Ye, Z, Nyalile, T, Li, Y, Glass, Z, Zhao, X, Yang, L, Chen, J, Xu, Q et al.. 2021. Sci Adv 7, .
    doi: 10.1126/sciadv.abf1244PMID:33952519
  2. Clarity on the crackdown. Lodish, H, Chen, J, Sharp, P. 2021. Science 371, 867.
    doi: 10.1126/science.abh1627PMID:33632822
  3. High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming. Hu, G, Su, Y, Kang, BH, Fan, Z, Dong, T, Brown, DR, Cheah, J, Wittrup, KD, Chen, J. 2021. Nat Commun 12, 773.
    doi: 10.1038/s41467-021-21066-xPMID:33536439
  4. Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics. Yong, KSM, Her, Z, Tan, SY, Tan, WWS, Liu, M, Lai, F, Heng, SM, Fan, Y, Chang, KTE, Wang, CI et al.. 2020. Front Immunol 11, 553362.
    doi: 10.3389/fimmu.2020.553362PMID:33193321
  5. Successive Immunization With Epitope-Decreasing Dengue Antigens Induced Conservative Anti-Dengue Immune Responses. Hou, J, Ye, W, Loo, HL, Wong, LH, Chen, J. 2020. Front Immunol 11, 585133.
    doi: 10.3389/fimmu.2020.585133PMID:33101316
  6. CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Xie, G, Ivica, NA, Jia, B, Li, Y, Dong, H, Liang, Y, Brown, D, Romee, R, Chen, J. 2021. Nat Biomed Eng 5, 399-413.
    doi: 10.1038/s41551-020-00625-5PMID:33046866
  7. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li, Y, Ivica, NA, Dong, T, Papageorgiou, DP, He, Y, Brown, DR, Kleyman, M, Hu, G, Chen, WW, Sullivan, LB et al.. 2020. Nat Commun 11, 4837.
    doi: 10.1038/s41467-020-18607-1PMID:32973183
  8. LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. Yeboah, M, Papagregoriou, C, Jones, DC, Chan, HTC, Hu, G, McPartlan, JS, Schiött, T, Mattson, U, Mockridge, CI, Tornberg, UC et al.. 2020. JCI Insight 5, .
    doi: 10.1172/jci.insight.141593PMID:32870822
  9. CAR-NK cells: A promising cellular immunotherapy for cancer. Xie, G, Dong, H, Liang, Y, Ham, JD, Rizwan, R, Chen, J. 2020. EBioMedicine 59, 102975.
    doi: 10.1016/j.ebiom.2020.102975PMID:32853984
  10. Corrigendum: IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation. Liu, X, Li, F, Niu, H, Ma, L, Chen, J, Zhang, Y, Peng, L, Gan, C, Ma, X, Zhu, B et al.. 2020. Front Immunol 11, 1671.
    doi: 10.3389/fimmu.2020.01671PMID:32849579
More Publications
Photo credit: Kelsey Montgomery