Jianzhu Chen

Jianzhu Chen

Professor of Biology; Singapore Research Professor

Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore treatment and prevention for cancer, as well as metabolic and infectious diseases.

617-258-6173

Phone

76-261

Office

Ryan Hayman

Assistant

617-253-0796

Assistant Phone

Education

  • PhD, 1990, Stanford University
  • BS, 1982, Biology, Wuhan University

Research Summary 

We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.

Awards

  • American Association for the Advancement of Science, Fellow, 2012

Key Publications

  1. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. Bidet, K, Ho, V, Chu, CW, Naim, ANH, Thazin, K, Chan, KR, Low, JGH, Choy, MM, Wong, LH, Florez de Sessions, P et al.. 2019. NPJ Vaccines 4, 27.
    doi: 10.1038/s41541-019-0119-3PMID:31285858
  2. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu, G, Dong, T, Wang, S, Jing, H, Chen, J. 2019. EBioMedicine 45, 563-577.
    doi: 10.1016/j.ebiom.2019.06.039PMID:31278070
  3. Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice. Kaur, M, Drake, AC, Hu, G, Rudnick, S, Chen, Q, Phennicie, R, Attar, R, Nemeth, J, Gaudet, F, Chen, J et al.. 2019. J. Immunol. 202, 1885-1894.
    doi: 10.4049/jimmunol.1800366PMID:30710044
  4. Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Chen, H, Cho, KS, Vu, THK, Shen, CH, Kaur, M, Chen, G, Mathew, R, McHam, ML, Fazelat, A, Lashkari, K et al.. 2018. Nat Commun 9, 3209.
    doi: 10.1038/s41467-018-05681-9PMID:30097565
  5. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
    doi: 10.1016/j.cell.2013.12.041PMID:24485462

Recent Publications

  1. LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. Yeboah, M, Papagregoriou, C, Jones, DC, Chan, HTC, Hu, G, McPartlan, JS, Schiött, T, Mattson, U, Mockridge, CI, Tornberg, UC et al.. 2020. JCI Insight 5, .
    doi: 10.1172/jci.insight.141593PMID:32870822
  2. CAR-NK cells: A promising cellular immunotherapy for cancer. Xie, G, Dong, H, Liang, Y, Ham, JD, Rizwan, R, Chen, J. 2020. EBioMedicine 59, 102975.
    doi: 10.1016/j.ebiom.2020.102975PMID:32853984
  3. Corrigendum: IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation. Liu, X, Li, F, Niu, H, Ma, L, Chen, J, Zhang, Y, Peng, L, Gan, C, Ma, X, Zhu, B et al.. 2020. Front Immunol 11, 1671.
    doi: 10.3389/fimmu.2020.01671PMID:32849579
  4. Microfluidic label-free bioprocessing of human reticulocytes from erythroid culture. Zeming, KK, Sato, Y, Yin, L, Huang, NJ, Wong, LH, Loo, HL, Lim, YB, Lim, CT, Chen, J, Preiser, PR et al.. 2020. Lab Chip 20, 3445-3460.
    doi: 10.1039/c9lc01128ePMID:32793940
  5. Sequential immunization induces strong and broad immunity against all four dengue virus serotypes. Hou, J, Shrivastava, S, Loo, HL, Wong, LH, Ooi, EE, Chen, J. 2020. NPJ Vaccines 5, 68.
    doi: 10.1038/s41541-020-00216-0PMID:32728482
  6. Rapid activation of distinct members of multigene families in Plasmodium spp. Omelianczyk, RI, Loh, HP, Chew, M, Hoo, R, Baumgarten, S, Renia, L, Chen, J, Preiser, PR. 2020. Commun Biol 3, 351.
    doi: 10.1038/s42003-020-1081-3PMID:32620892
  7. Temporal release of a three-component protein subunit vaccine from polymer multilayers. Uppu, DSSM, Turvey, ME, Sharif, ARM, Bidet, K, He, Y, Ho, V, Tambe, AD, Lescar, J, Tan, EY, Fink, K et al.. 2020. J Control Release 317, 130-141.
    doi: 10.1016/j.jconrel.2019.11.022PMID:31756392
  8. IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation. Liu, X, Li, F, Niu, H, Ma, L, Chen, J, Zhang, Y, Peng, L, Gan, C, Ma, X, Zhu, B et al.. 2019. Front Immunol 10, 2350.
    doi: 10.3389/fimmu.2019.02350PMID:31632413
  9. Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression. Roghanian, A, Hu, G, Fraser, C, Singh, M, Foxall, RB, Meyer, MJ, Lees, E, Huet, H, Glennie, MJ, Beers, SA et al.. 2019. Cancer Immunol Res 7, 1876-1890.
    doi: 10.1158/2326-6066.CIR-18-0835PMID:31451483
  10. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. Bidet, K, Ho, V, Chu, CW, Naim, ANH, Thazin, K, Chan, KR, Low, JGH, Choy, MM, Wong, LH, Florez de Sessions, P et al.. 2019. NPJ Vaccines 4, 27.
    doi: 10.1038/s41541-019-0119-3PMID:31285858
More Publications
Photo credit: Kelsey Montgomery