Jianzhu Chen

Jianzhu Chen

Professor of Biology; Singapore Research Professor

Jianzhu Chen studies the immune system, harnessing the body’s defense force to explore cancer treatment and vaccine development.





Ryan Hayman



Assistant Phone


  • PhD, 1990, Stanford University
  • BS, 1982, Biology, Wuhan University

Research Summary 

We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.


  • American Association for the Advancement of Science, Fellow, 2012

Recent Publications

  1. Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. Bidet, K, Ho, V, Chu, CW, Naim, ANH, Thazin, K, Chan, KR, Low, JGH, Choy, MM, Wong, LH, Florez de Sessions, P et al.. 2019. NPJ Vaccines 4, 27.
    doi: 10.1038/s41541-019-0119-3PMID:31285858
  2. Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice. Hou, J, Shrivastava, S, Fraser, CC, Loo, HL, Wong, LH, Ho, V, Fink, K, Ooi, EE, Chen, J. 2019. Front Immunol 10, 1429.
    doi: 10.3389/fimmu.2019.01429PMID:31281322
  3. Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu, G, Dong, T, Wang, S, Jing, H, Chen, J. 2019. EBioMedicine 45, 563-577.
    doi: 10.1016/j.ebiom.2019.06.039PMID:31278070
  4. Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice. Kaur, M, Drake, AC, Hu, G, Rudnick, S, Chen, Q, Phennicie, R, Attar, R, Nemeth, J, Gaudet, F, Chen, J et al.. 2019. J. Immunol. 202, 1885-1894.
    doi: 10.4049/jimmunol.1800366PMID:30710044
  5. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. Ye, W, Chew, M, Hou, J, Lai, F, Leopold, SJ, Loo, HL, Ghose, A, Dutta, AK, Chen, Q, Ooi, EE et al.. 2018. PLoS Pathog. 14, e1007298.
    doi: 10.1371/journal.ppat.1007298PMID:30286211
  6. Culture and Differentiation of Lung Bronchiolar Epithelial Cells In Vitro. Zheng, D, Chen, J. 2018. Methods Mol. Biol. 1817, 33-40.
    doi: 10.1007/978-1-4939-8600-2_4PMID:29959700
  7. Antibiotics induce polarization of pleural macrophages to M2-like phenotype in patients with tuberculous pleuritis. Wang, S, Zhang, J, Sui, L, Xu, H, Piao, Q, Liu, Y, Qu, X, Sun, Y, Song, L, Li, D et al.. 2017. Sci Rep 7, 14982.
    doi: 10.1038/s41598-017-14808-9PMID:29101376
  8. Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules. Costa, VV, Ye, W, Chen, Q, Teixeira, MM, Preiser, P, Ooi, EE, Chen, J. 2017. MBio 8, .
    doi: 10.1128/mBio.00741-17PMID:28765218
  9. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro. Zheng, D, Soh, BS, Yin, L, Hu, G, Chen, Q, Choi, H, Han, J, Chow, VT, Chen, J. 2017. Sci Rep 7, 41661.
    doi: 10.1038/srep41661PMID:28128362
  10. Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling. Drake, A, Kaur, M, Iliopoulou, BP, Phennicie, R, Hanson, A, Chen, J. 2016. PLoS ONE 11, e0166280.
    doi: 10.1371/journal.pone.0166280PMID:27855183
More Publications
Photo credit: Kelsey Montgomery