Education
- PhD, 1990, University of London
- BSc, 1986, Biochemistry, University of York
Research Summary
We identify the proteins and pathways involved in tumorigenicity — establishing their mechanism of action in both normal and tumor cells. To do so, we use a combination of molecular and cellular analyses, mutant mouse models and genetic screens in zebrafish.Recent Publications
- MITF deficiency accelerates GNAQ-driven uveal melanoma. Phelps, GB, Hagen, HR, Amsterdam, A, Lees, JA. 2022. Proc Natl Acad Sci U S A 119, e2107006119.
doi: 10.1073/pnas.2107006119PMID:35512098 - Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. Mueller, HS, Fowler, CE, Dalin, S, Moiso, E, Udomlumleart, T, Garg, S, Hemann, MT, Lees, JA. 2021. Proc Natl Acad Sci U S A 118, .
doi: 10.1073/pnas.2024055118PMID:34408017 - E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. Hazan, R, Mori, M, Danielian, PS, Guen, VJ, Rubin, SM, Cardoso, WV, Lees, JA. 2021. Mol Biol Cell 32, ar1.
doi: 10.1091/mbc.E21-01-0039PMID:34260288 - The Rb tumor suppressor regulates epithelial cell migration and polarity. Parisi, T, Balsamo, M, Gertler, F, Lees, JA. 2018. Mol Carcinog 57, 1640-1650.
doi: 10.1002/mc.22886PMID:30084175 - Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Perez, DE, Henle, AM, Amsterdam, A, Hagen, HR, Lees, JA. 2018. Pigment Cell Melanoma Res 31, 604-613.
doi: 10.1111/pcmr.12700PMID:29570931 - EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen, VJ, Chavarria, TE, Kröger, C, Ye, X, Weinberg, RA, Lees, JA. 2017. Proc Natl Acad Sci U S A 114, E10532-E10539.
doi: 10.1073/pnas.1711534114PMID:29158396 - Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Braun, CJ, Stanciu, M, Boutz, PL, Patterson, JC, Calligaris, D, Higuchi, F, Neupane, R, Fenoglio, S, Cahill, DP, Wakimoto, H et al.. 2017. Cancer Cell 32, 411-426.e11.
doi: 10.1016/j.ccell.2017.08.018PMID:28966034 - E2f4 and E2f5 are essential for the development of the male reproductive system. Danielian, PS, Hess, RA, Lees, JA. 2016. Cell Cycle 15, 250-60.
doi: 10.1080/15384101.2015.1121350PMID:26825228 - BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance. Ferretti, R, Bhutkar, A, McNamara, MC, Lees, JA. 2016. Genes Dev 30, 18-33.
doi: 10.1101/gad.267757.115PMID:26679841 - Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. Parisi, T, Bronson, RT, Lees, JA. 2015. Oncogene 34, 5890-9.
doi: 10.1038/onc.2015.30PMID:25745996