Jacqueline Lees

Jacqueline Lees

Virginia and D.K. Ludwig Professor for Cancer Research; Associate Department Head; Associate Director, David H. Koch Institute for Integrative Cancer Research

Jacqueline Lees develops mouse and zebrafish models, identifying the molecular pathways leading to tumor formation.





Paul Thompson



Assistant Phone


  • PhD, 1990, University of London
  • BSc, 1986, Biochemistry, University of York

Research Summary

We identify the proteins and pathways involved in tumorigenicity — establishing their mechanism of action in both normal and tumor cells. To do so, we use a combination of molecular and cellular analyses, mutant mouse models and genetic screens in zebrafish.

Recent Publications

  1. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. Mueller, HS, Fowler, CE, Dalin, S, Moiso, E, Udomlumleart, T, Garg, S, Hemann, MT, Lees, JA. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2024055118PMID:34408017
  2. E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. Hazan, R, Mori, M, Danielian, PS, Guen, VJ, Rubin, SM, Cardoso, WV, Lees, JA. 2021. Mol Biol Cell 32, ar1.
    doi: 10.1091/mbc.E21-01-0039PMID:34260288
  3. The Rb tumor suppressor regulates epithelial cell migration and polarity. Parisi, T, Balsamo, M, Gertler, F, Lees, JA. 2018. Mol Carcinog 57, 1640-1650.
    doi: 10.1002/mc.22886PMID:30084175
  4. Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Perez, DE, Henle, AM, Amsterdam, A, Hagen, HR, Lees, JA. 2018. Pigment Cell Melanoma Res 31, 604-613.
    doi: 10.1111/pcmr.12700PMID:29570931
  5. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen, VJ, Chavarria, TE, Kröger, C, Ye, X, Weinberg, RA, Lees, JA. 2017. Proc Natl Acad Sci U S A 114, E10532-E10539.
    doi: 10.1073/pnas.1711534114PMID:29158396
  6. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Braun, CJ, Stanciu, M, Boutz, PL, Patterson, JC, Calligaris, D, Higuchi, F, Neupane, R, Fenoglio, S, Cahill, DP, Wakimoto, H et al.. 2017. Cancer Cell 32, 411-426.e11.
    doi: 10.1016/j.ccell.2017.08.018PMID:28966034
  7. E2f4 and E2f5 are essential for the development of the male reproductive system. Danielian, PS, Hess, RA, Lees, JA. 2016. Cell Cycle 15, 250-60.
    doi: 10.1080/15384101.2015.1121350PMID:26825228
  8. BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance. Ferretti, R, Bhutkar, A, McNamara, MC, Lees, JA. 2016. Genes Dev 30, 18-33.
    doi: 10.1101/gad.267757.115PMID:26679841
  9. Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. Parisi, T, Bronson, RT, Lees, JA. 2015. Oncogene 34, 5890-9.
    doi: 10.1038/onc.2015.30PMID:25745996
  10. Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Maynard, MA, Ferretti, R, Hilgendorf, KI, Perret, C, Whyte, P, Lees, JA. 2014. Oncogene 33, 3742-7.
    doi: 10.1038/onc.2013.333PMID:23955081
More Publications
Photo courtesy of the MIT Koch Institute for Integrative Cancer Research