Stefani Spranger

Stefani Spranger

Howard S. and Linda B. Stern Career Development Assistant Professor

Stefani Spranger studies how the body’s immune system interacts with growing tumors to harness the immune response to fight cancer.

617-715-5882

Phone

76-453D

Office

Paul Thompson

Assistant

617-258-0480

Assistant Phone

Education

PhD 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich (Germany)

Research Summary

We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.

Awards

  • Forbeck Fellow, 2015

Recent Publications

  1. A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion. Horton, B, Spranger, S. 2018. Immunity 49, 11-13.
    doi: 10.1016/j.immuni.2018.07.001PMID:30021140
  2. A team effort: natural killer cells on the first leg of the tumor immunity relay race. Fessenden, TB, Duong, E, Spranger, S. 2018. J Immunother Cancer 6, 67.
    doi: 10.1186/s40425-018-0380-4PMID:29986768
  3. Impact of oncogenic pathways on evasion of antitumour immune responses. Spranger, S, Gajewski, TF. 2018. Nat. Rev. Cancer 18, 139-147.
    doi: 10.1038/nrc.2017.117PMID:29326431
  4. Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment. Gajewski, TF, Corrales, L, Williams, J, Horton, B, Sivan, A, Spranger, S. 2017. Adv. Exp. Med. Biol. 1036, 19-31.
    doi: 10.1007/978-3-319-67577-0_2PMID:29275462
  5. Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity. Horton, BL, Williams, JB, Cabanov, A, Spranger, S, Gajewski, TF. 2018. Cancer Immunol Res 6, 14-24.
    doi: 10.1158/2326-6066.CIR-17-0249PMID:29097422
  6. Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Spranger, S, Dai, D, Horton, B, Gajewski, TF. 2017. Cancer Cell 31, 711-723.e4.
    doi: 10.1016/j.ccell.2017.04.003PMID:28486109
  7. Innate immune signaling and regulation in cancer immunotherapy. Corrales, L, Matson, V, Flood, B, Spranger, S, Gajewski, TF. 2017. Cell Res. 27, 96-108.
    doi: 10.1038/cr.2016.149PMID:27981969
  8. Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015. Ascierto, PA, Agarwala, S, Botti, G, Cesano, A, Ciliberto, G, Davies, MA, Demaria, S, Dummer, R, Eggermont, AM, Ferrone, S et al.. 2016. J Transl Med 14, 313.
    doi: 10.1186/s12967-016-1070-yPMID:27846884
  9. Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma. Spranger, S, Luke, JJ, Bao, R, Zha, Y, Hernandez, KM, Li, Y, Gajewski, AP, Andrade, J, Gajewski, TF. 2016. Proc. Natl. Acad. Sci. U.S.A. 113, E7759-E7768.
    doi: 10.1073/pnas.1609376113PMID:27837020
  10. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. Lund, AW, Wagner, M, Fankhauser, M, Steinskog, ES, Broggi, MA, Spranger, S, Gajewski, TF, Alitalo, K, Eikesdal, HP, Wiig, H et al.. 2016. J. Clin. Invest. 126, 3389-402.
    doi: 10.1172/JCI79434PMID:27525437
More Publications
Photo credit: Kelsey Montgomery