Education
PhD 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich (Germany)Research Summary
We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.Awards
- Forbeck Fellow, 2015
Recent Publications
- WNT/β-catenin pathway activation correlates with immune exclusion across human cancers. Luke, JJ, Bao, R, Sweis, RF, Spranger, S, Gajewski, TF. 2019. Clin. Cancer Res. , .
doi: 10.1158/1078-0432.CCR-18-1942PMID:30635339 - WNT Signaling in Cancer Immunosurveillance. Galluzzi, L, Spranger, S, Fuchs, E, López-Soto, A. 2019. Trends Cell Biol. 29, 44-65.
doi: 10.1016/j.tcb.2018.08.005PMID:30220580 - A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion. Horton, B, Spranger, S. 2018. Immunity 49, 11-13.
doi: 10.1016/j.immuni.2018.07.001PMID:30021140 - A team effort: natural killer cells on the first leg of the tumor immunity relay race. Fessenden, TB, Duong, E, Spranger, S. 2018. J Immunother Cancer 6, 67.
doi: 10.1186/s40425-018-0380-4PMID:29986768 - Impact of oncogenic pathways on evasion of antitumour immune responses. Spranger, S, Gajewski, TF. 2018. Nat. Rev. Cancer 18, 139-147.
doi: 10.1038/nrc.2017.117PMID:29326431 - Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment. Gajewski, TF, Corrales, L, Williams, J, Horton, B, Sivan, A, Spranger, S. 2017. Adv. Exp. Med. Biol. 1036, 19-31.
doi: 10.1007/978-3-319-67577-0_2PMID:29275462 - Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity. Horton, BL, Williams, JB, Cabanov, A, Spranger, S, Gajewski, TF. 2018. Cancer Immunol Res 6, 14-24.
doi: 10.1158/2326-6066.CIR-17-0249PMID:29097422 - Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Spranger, S, Dai, D, Horton, B, Gajewski, TF. 2017. Cancer Cell 31, 711-723.e4.
doi: 10.1016/j.ccell.2017.04.003PMID:28486109 - Innate immune signaling and regulation in cancer immunotherapy. Corrales, L, Matson, V, Flood, B, Spranger, S, Gajewski, TF. 2017. Cell Res. 27, 96-108.
doi: 10.1038/cr.2016.149PMID:27981969 - Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015. Ascierto, PA, Agarwala, S, Botti, G, Cesano, A, Ciliberto, G, Davies, MA, Demaria, S, Dummer, R, Eggermont, AM, Ferrone, S et al.. 2016. J Transl Med 14, 313.
doi: 10.1186/s12967-016-1070-yPMID:27846884