Education
- PhD, 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- MSc, Biology, 2008, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- BSc, Biology, 2005, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
Research Summary
We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.Awards
- Forbeck Fellow, 2015
Recent Publications
- Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade. Wang, C, Cui, A, Bukenya, M, Aung, A, Pradhan, D, Whittaker, CA, Agarwal, Y, Thomas, A, Liang, S, Amlashi, P et al.. 2021. Cell Rep 37, 110021.
doi: 10.1016/j.celrep.2021.110021PMID:34818534 - Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity. Duong, E, Fessenden, TB, Lutz, E, Dinter, T, Yim, L, Blatt, S, Bhutkar, A, Wittrup, KD, Spranger, S. 2022. Immunity 55, 308-323.e9.
doi: 10.1016/j.immuni.2021.10.020PMID:34800368 - Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non-small cell lung cancer. Horton, BL, Morgan, DM, Momin, N, Zagorulya, M, Torres-Mejia, E, Bhandarkar, V, Wittrup, KD, Love, JC, Spranger, S. 2021. Sci Immunol 6, eabi8800.
doi: 10.1126/sciimmunol.abi8800PMID:34714687 - Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma. Bao, R, Spranger, S, Hernandez, K, Zha, Y, Pytel, P, Luke, JJ, Gajewski, TF, Volchenboum, SL, Cohn, SL, Desai, AV et al.. 2021. J Immunother Cancer 9, .
doi: 10.1136/jitc-2021-002417PMID:34272305 - Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Luengo, A, Li, Z, Gui, DY, Sullivan, LB, Zagorulya, M, Do, BT, Ferreira, R, Naamati, A, Ali, A, Lewis, CA et al.. 2021. Mol Cell 81, 691-707.e6.
doi: 10.1016/j.molcel.2020.12.012PMID:33382985 - Direct and Indirect Regulators of Epithelial-Mesenchymal Transition-Mediated Immunosuppression in Breast Carcinomas. Dongre, A, Rashidian, M, Eaton, EN, Reinhardt, F, Thiru, P, Zagorulya, M, Nepal, S, Banaz, T, Martner, A, Spranger, S et al.. 2021. Cancer Discov 11, 1286-1305.
doi: 10.1158/2159-8290.CD-20-0603PMID:33328216 - Frontiers in cancer immunotherapy-a symposium report. Cable, J, Greenbaum, B, Pe'er, D, Bollard, CM, Bruni, S, Griffin, ME, Allison, JP, Wu, CJ, Subudhi, SK, Mardis, ER et al.. 2021. Ann N Y Acad Sci 1489, 30-47.
doi: 10.1111/nyas.14526PMID:33184911 - Impact of anatomic site on antigen-presenting cells in cancer. Zagorulya, M, Duong, E, Spranger, S. 2020. J Immunother Cancer 8, .
doi: 10.1136/jitc-2020-001204PMID:33020244 - Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. Ascierto, PA, Fox, BA, Urba, WJ, Anderson, AC, Atkins, MB, Borden, EC, Brahmer, JR, Butterfield, LH, Cesano, A, Chen, DC et al.. 2020. J Immunother Cancer 8, .
doi: 10.1136/jitc-2020-000878PMID:32300051 - Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. Cohen, MA, Zhang, S, Sengupta, S, Ma, H, Bell, GW, Horton, B, Sharma, B, George, RE, Spranger, S, Jaenisch, R et al.. 2020. Cell Stem Cell 26, 579-592.e6.
doi: 10.1016/j.stem.2020.02.001PMID:32142683
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