Stefani Spranger

Stefani Spranger

Howard S. and Linda B. Stern Career Development Professor

Stefani Spranger studies how the body’s immune system interacts with growing tumors to harness the immune response to fight cancer.





Paul Thompson



Assistant Phone


  • PhD, 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
  • MSc, Biology, 2008, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
  • BSc, Biology, 2005, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich

Research Summary

We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.


  • Forbeck Fellow, 2015

Recent Publications

  1. Impact of anatomic site on antigen-presenting cells in cancer. Zagorulya, M, Duong, E, Spranger, S. 2020. J Immunother Cancer 8, .
    doi: 10.1136/jitc-2020-001204PMID:33020244
  2. Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. Ascierto, PA, Fox, BA, Urba, WJ, Anderson, AC, Atkins, MB, Borden, EC, Brahmer, JR, Butterfield, LH, Cesano, A, Chen, DC et al.. 2020. J Immunother Cancer 8, .
    doi: 10.1136/jitc-2020-000878PMID:32300051
  3. Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. Cohen, MA, Zhang, S, Sengupta, S, Ma, H, Bell, GW, Horton, B, Sharma, B, George, RE, Spranger, S, Jaenisch, R et al.. 2020. Cell Stem Cell 26, 579-592.e6.
    doi: 10.1016/j.stem.2020.02.001PMID:32142683
  4. CD36 - the Achilles' heel of Treg cells. Horton, BL, Spranger, S. 2020. Nat Immunol 21, 251-253.
    doi: 10.1038/s41590-020-0601-0PMID:32066948
  5. Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling. Nguyen, KB, Spranger, S. 2020. J Cell Biol 219, .
    doi: 10.1083/jcb.201908224PMID:31816057
  6. Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy). Ascierto, PA, Bifulco, C, Buonaguro, L, Emens, LA, Ferris, RL, Fox, BA, Delgoffe, GM, Galon, J, Gridelli, C, Merlano, M et al.. 2019. J Immunother Cancer 7, 332.
    doi: 10.1186/s40425-019-0798-3PMID:31783779
  7. Tissue Site and the Cancer Immunity Cycle. Horton, BL, Fessenden, TB, Spranger, S. 2019. Trends Cancer 5, 593-603.
    doi: 10.1016/j.trecan.2019.07.006PMID:31706507
  8. Secondary resistance to immunotherapy associated with β-catenin pathway activation or PTEN loss in metastatic melanoma. Trujillo, JA, Luke, JJ, Zha, Y, Segal, JP, Ritterhouse, LL, Spranger, S, Matijevich, K, Gajewski, TF. 2019. J Immunother Cancer 7, 295.
    doi: 10.1186/s40425-019-0780-0PMID:31703593
  9. Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. Bedognetti, D, Ceccarelli, M, Galluzzi, L, Lu, R, Palucka, K, Samayoa, J, Spranger, S, Warren, S, Wong, KK, Ziv, E et al.. 2019. J Immunother Cancer 7, 167.
    doi: 10.1186/s40425-019-0640-yPMID:31272507
  10. Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Momin, N, Mehta, NK, Bennett, NR, Ma, L, Palmeri, JR, Chinn, MM, Lutz, EA, Kang, B, Irvine, DJ, Spranger, S et al.. 2019. Sci Transl Med 11, .
    doi: 10.1126/scitranslmed.aaw2614PMID:31243150
More Publications


Photo credit: Kelsey Montgomery