Education
- PhD, 2011, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- MSc, Biology, 2008, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
- BSc, Biology, 2005, Ludwig-Maximilian University Munich/Helmholtz-Zentrum Munich
Research Summary
We examine the interaction between cancer and immune cells. Using tumor mouse models designed to mimic tumor progression in humans, we investigate the co-evolution of the anti-tumor immune response and cancer. Understanding the interplay between tumor cells and immune cells will help develop and improve effective cancer immunotherapies.Awards
- Forbeck Fellow, 2015
Recent Publications
- Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Luengo, A, Li, Z, Gui, DY, Sullivan, LB, Zagorulya, M, Do, BT, Ferreira, R, Naamati, A, Ali, A, Lewis, CA et al.. 2020. Mol Cell , .
doi: 10.1016/j.molcel.2020.12.012PMID:33382985 - Direct and Indirect Regulators of Epithelial-Mesenchymal Transition (EMT)-mediated Immunosuppression in Breast Carcinomas. Dongre, A, Rashidian, M, Eaton, EN, Reinhardt, F, Thiru, P, Zagorulya, M, Nepal, S, Banaz, T, Martner, A, Spranger, S et al.. 2020. Cancer Discov , .
doi: 10.1158/2159-8290.CD-20-0603PMID:33328216 - Frontiers in cancer immunotherapy-a symposium report. Cable, J, Greenbaum, B, Pe'er, D, Bollard, CM, Bruni, S, Griffin, ME, Allison, JP, Wu, CJ, Subudhi, SK, Mardis, ER et al.. 2020. Ann N Y Acad Sci , .
doi: 10.1111/nyas.14526PMID:33184911 - Impact of anatomic site on antigen-presenting cells in cancer. Zagorulya, M, Duong, E, Spranger, S. 2020. J Immunother Cancer 8, .
doi: 10.1136/jitc-2020-001204PMID:33020244 - Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. Ascierto, PA, Fox, BA, Urba, WJ, Anderson, AC, Atkins, MB, Borden, EC, Brahmer, JR, Butterfield, LH, Cesano, A, Chen, DC et al.. 2020. J Immunother Cancer 8, .
doi: 10.1136/jitc-2020-000878PMID:32300051 - Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. Cohen, MA, Zhang, S, Sengupta, S, Ma, H, Bell, GW, Horton, B, Sharma, B, George, RE, Spranger, S, Jaenisch, R et al.. 2020. Cell Stem Cell 26, 579-592.e6.
doi: 10.1016/j.stem.2020.02.001PMID:32142683 - CD36 - the Achilles' heel of Treg cells. Horton, BL, Spranger, S. 2020. Nat Immunol 21, 251-253.
doi: 10.1038/s41590-020-0601-0PMID:32066948 - Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling. Nguyen, KB, Spranger, S. 2020. J Cell Biol 219, .
doi: 10.1083/jcb.201908224PMID:31816057 - Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy). Ascierto, PA, Bifulco, C, Buonaguro, L, Emens, LA, Ferris, RL, Fox, BA, Delgoffe, GM, Galon, J, Gridelli, C, Merlano, M et al.. 2019. J Immunother Cancer 7, 332.
doi: 10.1186/s40425-019-0798-3PMID:31783779 - Tissue Site and the Cancer Immunity Cycle. Horton, BL, Fessenden, TB, Spranger, S. 2019. Trends Cancer 5, 593-603.
doi: 10.1016/j.trecan.2019.07.006PMID:31706507