Eric S. Lander

Eric S. Lander

Professor of Biology; Professor of Systems Biology, Harvard Medical School; Founding Director, Broad Institute of MIT and Harvard

Eric S. Lander is interested in every aspect of the human genome and its application to medicine.

617-714-7010

Phone

NE30-6013

Office

Nicole Brellenthin

Assistant

617-714-7012

Assistant Phone

Education

PhD, 1981 Oxford University

Research Summary

Following the successful completion of the Human Genome Project, the challenge now is to decipher the information encoded within the human genetic code — including genes, regulatory controls and cellular circuitry. Such understanding is fundamental to the study of physiology in both health and disease. At the Broad Institute, my lab collaborates with other to discover and understand the genes responsible for rare genetic diseases, common diseases, and cancer; the genetic variation and evolution of the human genome; the basis of gene regulation via enhancers, long non-coding RNAs, and three-dimensional folding of the genome; the developmental trajectories of cellular differentiation; and the history of the human population.

Awards

  • James R. Killian, Jr. Faculty Achievement Award, MIT, 2016
  • Block Memorial Award for Distinguished Achievement in Cancer Research, Ohio State University, 2013
  • AAAS Philip Hauge Abelson Prize, 2015
  • Breakthrough Prize in Life Sciences, 2013
  • Harvey Prize for Human Health, Technion University, Israel, 2012
  • Dan David Prize, 2012
  • Albany Prize in Medicine and Biomedical Research, Albany Medical College, 2010
  • Gairdner Foundation International Award, Canada, 2002
  • Max Delbruck Medal, Berlin, 2001
  • MacArthur Foundation, MacArthur Fellowship, 1987

Key Publications

  1. Genetic screens in human cells using the CRISPR-Cas9 system. Wang, T, Wei, JJ, Sabatini, DM, Lander, ES. 2014. Science 343, 80-4.
    doi: 10.1126/science.1246981PMID:24336569
  2. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Lieberman-Aiden, E, van Berkum, NL, Williams, L, Imakaev, M, Ragoczy, T, Telling, A, Amit, I, Lajoie, BR, Sabo, PJ, Dorschner, MO et al.. 2009. Science 326, 289-93.
    doi: 10.1126/science.1181369PMID:19815776
  3. Initial sequencing and comparative analysis of the mouse genome. Mouse Genome Sequencing Consortium, Waterston, RH, Lindblad-Toh, K, Birney, E, Rogers, J, Abril, JF, Agarwal, P, Agarwala, R, Ainscough, R, Alexandersson, M et al.. 2002. Nature 420, 520-62.
    doi: 10.1038/nature01262PMID:12466850
  4. High-resolution haplotype structure in the human genome. Daly, MJ, Rioux, JD, Schaffner, SF, Hudson, TJ, Lander, ES. 2001. Nat. Genet. 29, 229-32.
    doi: 10.1038/ng1001-229PMID:11586305
  5. Initial sequencing and analysis of the human genome. Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J, Devon, K, Dewar, K, Doyle, M, FitzHugh, W et al.. 2001. Nature 409, 860-921.
    doi: 10.1038/35057062PMID:11237011

Recent Publications

  1. Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Yassour, M, Jason, E, Hogstrom, LJ, Arthur, TD, Tripathi, S, Siljander, H, Selvenius, J, Oikarinen, S, Hyöty, H, Virtanen, SM et al.. 2018. Cell Host Microbe 24, 146-154.e4.
    doi: 10.1016/j.chom.2018.06.007PMID:30001517
  2. Positional specificity of different transcription factor classes within enhancers. Grossman, SR, Engreitz, J, Ray, JP, Nguyen, TH, Hacohen, N, Lander, ES. 2018. Proc. Natl. Acad. Sci. U.S.A. 115, E7222-E7230.
    doi: 10.1073/pnas.1804663115PMID:29987030
  3. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Khajuria, RK, Munschauer, M, Ulirsch, JC, Fiorini, C, Ludwig, LS, McFarland, SK, Abdulhay, NJ, Specht, H, Keshishian, H, Mani, DR et al.. 2018. Cell 173, 90-103.e19.
    doi: 10.1016/j.cell.2018.02.036PMID:29551269
  4. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Flannick, J, Fuchsberger, C, Mahajan, A, Teslovich, TM, Agarwala, V, Gaulton, KJ, Caulkins, L, Koesterer, R, Ma, C, Moutsianas, L et al.. 2017. Sci Data 4, 170179.
    doi: 10.1038/sdata.2017.179PMID:29257133
  5. The Human Cell Atlas. Regev, A, Teichmann, SA, Lander, ES, Amit, I, Benoist, C, Birney, E, Bodenmiller, B, Campbell, P, Carninci, P, Clatworthy, M et al.. 2017. Elife 6, .
    doi: 10.7554/eLife.27041PMID:29206104
  6. A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients. Hall, AB, Yassour, M, Sauk, J, Garner, A, Jiang, X, Arthur, T, Lagoudas, GK, Vatanen, T, Fornelos, N, Wilson, R et al.. 2017. Genome Med 9, 103.
    doi: 10.1186/s13073-017-0490-5PMID:29183332
  7. Efficient Generation of Transcriptomic Profiles by Random Composite Measurements. Cleary, B, Cong, L, Cheung, A, Lander, ES, Regev, A. 2017. Cell 171, 1424-1436.e18.
    doi: 10.1016/j.cell.2017.10.023PMID:29153835
  8. RNA targeting with CRISPR-Cas13. Abudayyeh, OO, Gootenberg, JS, Essletzbichler, P, Han, S, Joung, J, Belanto, JJ, Verdine, V, Cox, DBT, Kellner, MJ, Regev, A et al.. 2017. Nature 550, 280-284.
    doi: 10.1038/nature24049PMID:28976959
  9. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds. Dudchenko, O, Batra, SS, Omer, AD, Nyquist, SK, Hoeger, M, Durand, NC, Shamim, MS, Machol, I, Lander, ES, Aiden, AP et al.. 2017. Science 356, 92-95.
    doi: 10.1126/science.aal3327PMID:28336562
  10. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang, T, Yu, H, Hughes, NW, Liu, B, Kendirli, A, Klein, K, Chen, WW, Lander, ES, Sabatini, DM. 2017. Cell 168, 890-903.e15.
    doi: 10.1016/j.cell.2017.01.013PMID:28162770
More Publications

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Photo credit: Casey Atkins