David C. Page

David C. Page

Professor of Biology; Director, Whitehead Institute; Investigator, Howard Hughes Medical Institute

David C. Page examines the genetic differences between males and females — and how these play out in disease, development, and evolution.





Susan Tocio



Assistant Phone


MD 1984, Harvard Medical School

Research Summary

We seek to understand the genetic differences between males and females — both within and beyond the reproductive tract. We study the medical ramifications of these differences in a broad context, through comparative biological, evolutionary, developmental and clinically focused analyses. Our three main veins of research relate to sex differences in health and disease, sex chromosome genomics, and germ cell origins and development.


  • American Academy of Arts and Sciences, Fellow, 2012
  • March of Dimes, Developmental Biology, 2011
  • National Academy of Medicine, Member, 2008
  • National Academy of Sciences, Member, 2005
  • Howard Hughes Medical Institute, HHMI Investigator, 1990
  • MacArthur Foundation, MacArthur Fellowship, 1986

Recent Publications

  1. Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution. Naqvi, S, Bellott, DW, Lin, KS, Page, DC. 2018. Genome Res. , .
    doi: 10.1101/gr.230433.117PMID: 29449410
  2. Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis. Endo, T, Freinkman, E, de Rooij, DG, Page, DC. 2017. Proc. Natl. Acad. Sci. U.S.A. 114, E10132-E10141.
    doi: 10.1073/pnas.1710837114PMID: 29109271
  3. Meioc maintains an extended meiotic prophase I in mice. Soh, YQS, Mikedis, MM, Kojima, M, Godfrey, AK, de Rooij, DG, Page, DC. 2017. PLoS Genet. 13, e1006704.
    doi: 10.1371/journal.pgen.1006704PMID: 28380054
  4. Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators. Bellott, DW, Skaletsky, H, Cho, TJ, Brown, L, Locke, D, Chen, N, Galkina, S, Pyntikova, T, Koutseva, N, Graves, T et al.. 2017. Nat. Genet. 49, 387-394.
    doi: 10.1038/ng.3778PMID: 28135246
  5. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Carmell, MA, Dokshin, GA, Skaletsky, H, Hu, YC, van Wolfswinkel, JC, Igarashi, KJ, Bellott, DW, Nefedov, M, Reddien, PW, Enders, GC et al.. 2016. Elife 5, .
    doi: 10.7554/eLife.19993PMID: 27718356
  6. Parallel evolution of male germline epigenetic poising and somatic development in animals. Lesch, BJ, Silber, SJ, McCarrey, JR, Page, DC. 2016. Nat. Genet. 48, 888-94.
    doi: 10.1038/ng.3591PMID: 27294618
  7. The history of the Y chromosome in man. Hughes, JF, Page, DC. 2016. Nat. Genet. 48, 588-9.
    doi: 10.1038/ng.3580PMID: 27230683
  8. The Biology and Evolution of Mammalian Y Chromosomes. Hughes, JF, Page, DC. 2015. Annu. Rev. Genet. 49, 507-27.
    doi: 10.1146/annurev-genet-112414-055311PMID: 26442847
  9. A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary. Soh, YQ, Junker, JP, Gill, ME, Mueller, JL, van Oudenaarden, A, Page, DC. 2015. PLoS Genet. 11, e1005531.
    doi: 10.1371/journal.pgen.1005531PMID: 26378784
  10. Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals. Hughes, JF, Skaletsky, H, Koutseva, N, Pyntikova, T, Page, DC. 2015. Genome Biol. 16, 104.
    doi: 10.1186/s13059-015-0667-4PMID: 26017895
More Publications


Photo credit: Gretchen Ertl/Whitehead Institute