David C. Page

David C. Page

Professor of Biology; Member, Whitehead Institute; Investigator, Howard Hughes Medical Institute

David C. Page examines the genetic differences between males and females — and how these play out in disease, development, and evolution.





Susan Tocio



Assistant Phone


  • MD, 1984, Harvard Medical School
  • BS, 1978, Chemistry, Swarthmore College

Research Summary

We seek to understand the genetic differences between males and females — both within and beyond the reproductive tract. We study the medical ramifications of these differences in a broad context, through comparative biological, evolutionary, developmental and clinically focused analyses. Our three main veins of research relate to sex differences in health and disease, sex chromosome genomics, and germ cell origins and development.


  • American Academy of Arts and Sciences, Fellow, 2012
  • March of Dimes, Developmental Biology, 2011
  • National Academy of Medicine, Member, 2008
  • National Academy of Sciences, Member, 2005
  • Howard Hughes Medical Institute, HHMI Investigator, 1990
  • MacArthur Foundation, MacArthur Fellowship, 1986

Recent Publications

  1. Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals. Bellott, DW, Page, DC. 2021. Genome Res , .
    doi: 10.1101/gr.268516.120PMID:33479023
  2. Sequence analysis in Bos taurus reveals pervasiveness of X-Y arms races in mammalian lineages. Hughes, JF, Skaletsky, H, Pyntikova, T, Koutseva, N, Raudsepp, T, Brown, LG, Bellott, DW, Cho, TJ, Dugan-Rocha, S, Khan, Z et al.. 2020. Genome Res 30, 1716-1726.
    doi: 10.1101/gr.269902.120PMID:33208454
  3. DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors. Mikedis, MM, Fan, Y, Nicholls, PK, Endo, T, Jackson, EK, Cobb, SA, de Rooij, DG, Page, DC. 2020. Elife 9, .
    doi: 10.7554/eLife.56523PMID:32686646
  4. Quantitative analysis of Y-Chromosome gene expression across 36 human tissues. Godfrey, AK, Naqvi, S, Chmátal, L, Chick, JM, Mitchell, RN, Gygi, SP, Skaletsky, H, Page, DC. 2020. Genome Res 30, 860-873.
    doi: 10.1101/gr.261248.120PMID:32461223
  5. Mammalian germ cells are determined after PGC colonization of the nascent gonad. Nicholls, PK, Schorle, H, Naqvi, S, Hu, YC, Fan, Y, Carmell, MA, Dobrinski, I, Watson, AL, Carlson, DF, Fahrenkrug, SC et al.. 2019. Proc Natl Acad Sci U S A 116, 25677-25687.
    doi: 10.1073/pnas.1910733116PMID:31754036
  6. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals. Naqvi, S, Godfrey, AK, Hughes, JF, Goodheart, ML, Mitchell, RN, Page, DC. 2019. Science 365, .
    doi: 10.1126/science.aaw7317PMID:31320509
  7. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. Lesch, BJ, Tothova, Z, Morgan, EA, Liao, Z, Bronson, RT, Ebert, BL, Page, DC. 2019. Elife 8, .
    doi: 10.7554/eLife.39380PMID:30963999
  8. Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing. Nicholls, PK, Bellott, DW, Cho, TJ, Pyntikova, T, Page, DC. 2019. G3 (Bethesda) 9, 1481-1486.
    doi: 10.1534/g3.119.300582PMID:30837263
  9. Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice. Kojima, ML, de Rooij, DG, Page, DC. 2019. Elife 8, .
    doi: 10.7554/eLife.43738PMID:30810530
  10. A strategic research alliance: Turner syndrome and sex differences. San Roman, AK, Page, DC. 2019. Am J Med Genet C Semin Med Genet 181, 59-67.
    doi: 10.1002/ajmg.c.31677PMID:30790449
More Publications


Photo credit: Gretchen Ertl/Whitehead Institute