Education
- PhD, 2001, Johns Hopkins University
- BS, 1993, Molecular Biology and Biochemistry, Wesleyan University
Research Summary
Many human cancers do not respond to chemotherapy, and often times those that initially respond eventually acquire drug resistance. Our lab uses high-throughput screening technology — combined with murine stem reconstitution and tumor transplantation systems — to investigate the genetic basis for this resistance. Our goal is to identify novel cancer drug targets, as well as strategies for tailoring existing cancer therapies to target the vulnerabilities associated with specific malignancies.Key Publications
Recent Publications
- Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Ramos, A, Koch, CE, Liu-Lupo, Y, Hellinger, RD, Kyung, T, Abbott, KL, Fröse, J, Goulet, D, Gordon, KS, Eidell, KP et al.. 2023. Nat Commun 14, 8048.
doi: 10.1038/s41467-023-43790-2PMID:38052854 - Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia. Liu-Lupo, Y, Ham, JD, Jeewajee, SKA, Nguyen, L, Delorey, T, Ramos, A, Weinstock, DM, Regev, A, Hemann, MT. 2023. Blood Cancer J 13, 92.
doi: 10.1038/s41408-023-00863-1PMID:37286545 - Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse. Dalin, S, Grauman-Boss, B, Lauffenburger, DA, Hemann, MT. 2022. Sci Rep 12, 5453.
doi: 10.1038/s41598-022-09319-1PMID:35361803 - Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Bent, EH, Millán-Barea, LR, Zhuang, I, Goulet, DR, Fröse, J, Hemann, MT. 2021. Nat Commun 12, 6218.
doi: 10.1038/s41467-021-26407-4PMID:34711820 - Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. Vassel, FM, Bian, K, Walker, GC, Hemann, MT. 2020. Proc Natl Acad Sci U S A 117, 28922-28924.
doi: 10.1073/pnas.2016067117PMID:33144509 - Integrated regulatory models for inference of subtype-specific susceptibilities in glioblastoma. Liu, Y, Shi, N, Regev, A, He, S, Hemann, MT. 2020. Mol Syst Biol 16, e9506.
doi: 10.15252/msb.20209506PMID:32974985 - Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Dalin, S, Sullivan, MR, Lau, AN, Grauman-Boss, B, Mueller, HS, Kreidl, E, Fenoglio, S, Luengo, A, Lees, JA, Vander Heiden, MG et al.. 2019. Cancer Res 79, 5723-5733.
doi: 10.1158/0008-5472.CAN-19-0960PMID:31484670 - Functional screens identify coordinators of RNA molecule birth, life, and death as targetable cancer vulnerabilities. Braun, CJ, Hemann, MT. 2019. Curr Opin Genet Dev 54, 105-109.
doi: 10.1016/j.gde.2019.04.003PMID:31121413 - In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL. Fiedler, ERC, Bhutkar, A, Lawler, E, Besada, R, Hemann, MT. 2018. Blood Adv 2, 1229-1242.
doi: 10.1182/bloodadvances.2017015610PMID:29853524 - Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes Chemoresistance in Colorectal Cancer. Ramos, A, Hemann, MT. 2017. Cell 170, 411-413.
doi: 10.1016/j.cell.2017.07.018PMID:28753421