Olivia Corradin

Olivia Corradin

Assistant Professor of Biology

Olivia Corradin investigates the genetic and epigenetic changes in gene regulatory elements that influence human disease.

Education

  • PhD, 2015, Case Western Reserve University
  • BS, 2010, Biochemistry, Marquette University

Research Summary

Our lab studies genetic and epigenetic variation that contributes to human disease by disrupting gene expression programs. We utilize biological insights into the mechanisms of gene regulation in order to determine the impact of disease-associated variants on cellular function. We aim to identify actionable insights into disease pathogenesis by studying the confluence of genetic and epigenetic risk factors of human diseases, including multiple sclerosis and opioid use disorder.

Awards

  • NIH Director's Pioneer Award Program Avenir Award, 2017

Key Publications

  1. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor, DC, Barbeau, AM, Allan, KC, Hu, LR, Madhavan, M, Hoang, AT, Hazel, KEA, Hall, PA, Nisraiyya, S, Najm, FJ et al.. 2020. Cell 181, 382-395.e21.
    doi: 10.1016/j.cell.2020.03.002PMID:32246942
  2. Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Corradin, O, Cohen, AJ, Luppino, JM, Bayles, IM, Schumacher, FR, Scacheri, PC. 2016. Nat Genet 48, 1313-1320.
    doi: 10.1038/ng.3674PMID:27643537
  3. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Corradin, O, Saiakhova, A, Akhtar-Zaidi, B, Myeroff, L, Willis, J, Cowper-Sal lari, R, Lupien, M, Markowitz, S, Scacheri, PC. 2014. Genome Res 24, 1-13.
    doi: 10.1101/gr.164079.113PMID:24196873

Recent Publications

  1. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor, DC, Barbeau, AM, Allan, KC, Hu, LR, Madhavan, M, Hoang, AT, Hazel, KEA, Hall, PA, Nisraiyya, S, Najm, FJ et al.. 2020. Cell 181, 382-395.e21.
    doi: 10.1016/j.cell.2020.03.002PMID:32246942
  2. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Lager, AM, Corradin, OG, Cregg, JM, Elitt, MS, Shick, HE, Clayton, BLL, Allan, KC, Olsen, HE, Madhavan, M, Tesar, PJ et al.. 2018. Nat Commun 9, 3708.
    doi: 10.1038/s41467-018-06102-7PMID:30213958
  3. Publisher Correction: ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Bailey, SD, Zhang, X, Desai, K, Aid, M, Corradin, O, Cowper-Sal Lari, R, Akhtar-Zaidi, B, Scacheri, PC, Haibe-Kains, B, Lupien, M et al.. 2018. Nat Commun 9, 16194.
    doi: 10.1038/ncomms16194PMID:29633758
  4. Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome. Cohen, AJ, Saiakhova, A, Corradin, O, Luppino, JM, Lovrenert, K, Bartels, CF, Morrow, JJ, Mack, SC, Dhillon, G, Beard, L et al.. 2017. Nat Commun 8, 14400.
    doi: 10.1038/ncomms14400PMID:28169291
  5. Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Corradin, O, Cohen, AJ, Luppino, JM, Bayles, IM, Schumacher, FR, Scacheri, PC. 2016. Nat Genet 48, 1313-1320.
    doi: 10.1038/ng.3674PMID:27643537
  6. ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Bailey, SD, Zhang, X, Desai, K, Aid, M, Corradin, O, Cowper-Sal Lari, R, Akhtar-Zaidi, B, Scacheri, PC, Haibe-Kains, B, Lupien, M et al.. 2015. Nat Commun 2, 6186.
    doi: 10.1038/ncomms7186PMID:25645053
  7. Long ncRNA expression associates with tissue-specific enhancers. Vučićević, D, Corradin, O, Ntini, E, Scacheri, PC, Ørom, UA. 2015. Cell Cycle 14, 253-60.
    doi: 10.4161/15384101.2014.977641PMID:25607649
  8. Enhancer variants: evaluating functions in common disease. Corradin, O, Scacheri, PC. 2014. Genome Med 6, 85.
    doi: 10.1186/s13073-014-0085-3PMID:25473424
  9. Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. Factor, DC, Corradin, O, Zentner, GE, Saiakhova, A, Song, L, Chenoweth, JG, McKay, RD, Crawford, GE, Scacheri, PC, Tesar, PJ et al.. 2014. Cell Stem Cell 14, 854-63.
    doi: 10.1016/j.stem.2014.05.005PMID:24905169
  10. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Corradin, O, Saiakhova, A, Akhtar-Zaidi, B, Myeroff, L, Willis, J, Cowper-Sal lari, R, Lupien, M, Markowitz, S, Scacheri, PC. 2014. Genome Res 24, 1-13.
    doi: 10.1101/gr.164079.113PMID:24196873
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