Olivia Corradin

Olivia Corradin

Class of 1922 Career Development Professor; Core Member, Whitehead Institute

Olivia Corradin investigates the genetic and epigenetic changes in gene regulatory elements that influence human disease.

617-324-6481

Phone

WI-461

Office

corradin@wi.mit.edu

Email

Whitehead Institute for Biomedical Research

Location

Lab Website
Aline Niyonkuru

Assistant

617-258-5217

Assistant Phone

Education

  • PhD, 2015, Case Western Reserve University
  • BS, 2010, Biochemistry, Marquette University

Research Summary

Our lab studies genetic and epigenetic variation that contributes to human disease by disrupting gene expression programs. We utilize biological insights into the mechanisms of gene regulation in order to determine the impact of disease-associated variants on cellular function. We aim to identify actionable insights into disease pathogenesis by studying the confluence of genetic and epigenetic risk factors of human diseases, including multiple sclerosis and opioid use disorder.

Awards

  • NIH Director's Pioneer Award Program Avenir Award, 2017

Key Publications

  1. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor, DC, Barbeau, AM, Allan, KC, Hu, LR, Madhavan, M, Hoang, AT, Hazel, KEA, Hall, PA, Nisraiyya, S, Najm, FJ et al.. 2020. Cell 181, 382-395.e21.
    doi: 10.1016/j.cell.2020.03.002PMID:32246942
  2. Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Corradin, O, Cohen, AJ, Luppino, JM, Bayles, IM, Schumacher, FR, Scacheri, PC. 2016. Nat Genet 48, 1313-1320.
    doi: 10.1038/ng.3674PMID:27643537
  3. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Corradin, O, Saiakhova, A, Akhtar-Zaidi, B, Myeroff, L, Willis, J, Cowper-Sal lari, R, Lupien, M, Markowitz, S, Scacheri, PC. 2014. Genome Res 24, 1-13.
    doi: 10.1101/gr.164079.113PMID:24196873

Recent Publications

  1. Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex. Carter, JK, Quach, BC, Willis, C, Minto, MS, PGC-SUD Epigenetics Working Group, Hancock, DB, Montalvo-Ortiz, J, Corradin, O, Logan, RW, Walss-Bass, C et al.. 2024. medRxiv , .
    doi: 10.1101/2024.01.12.24301153PMID:38260365
  2. Epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose. Hoang, AT, Corradin, O. 2024. Neuropsychopharmacology 49, 333-334.
    doi: 10.1038/s41386-023-01701-5PMID:37587380
  3. Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose. Corradin, O, Sallari, R, Hoang, AT, Kassim, BS, Ben Hutta, G, Cuoto, L, Quach, BC, Lovrenert, K, Hays, C, Gryder, BE et al.. 2022. Mol Psychiatry 27, 2158-2170.
    doi: 10.1038/s41380-022-01477-yPMID:35301427
  4. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor, DC, Barbeau, AM, Allan, KC, Hu, LR, Madhavan, M, Hoang, AT, Hazel, KEA, Hall, PA, Nisraiyya, S, Najm, FJ et al.. 2020. Cell 181, 382-395.e21.
    doi: 10.1016/j.cell.2020.03.002PMID:32246942
  5. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Lager, AM, Corradin, OG, Cregg, JM, Elitt, MS, Shick, HE, Clayton, BLL, Allan, KC, Olsen, HE, Madhavan, M, Tesar, PJ et al.. 2018. Nat Commun 9, 3708.
    doi: 10.1038/s41467-018-06102-7PMID:30213958
  6. Publisher Correction: ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Bailey, SD, Zhang, X, Desai, K, Aid, M, Corradin, O, Cowper-Sal Lari, R, Akhtar-Zaidi, B, Scacheri, PC, Haibe-Kains, B, Lupien, M et al.. 2018. Nat Commun 9, 16194.
    doi: 10.1038/ncomms16194PMID:29633758
  7. Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome. Cohen, AJ, Saiakhova, A, Corradin, O, Luppino, JM, Lovrenert, K, Bartels, CF, Morrow, JJ, Mack, SC, Dhillon, G, Beard, L et al.. 2017. Nat Commun 8, 14400.
    doi: 10.1038/ncomms14400PMID:28169291
  8. Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Corradin, O, Cohen, AJ, Luppino, JM, Bayles, IM, Schumacher, FR, Scacheri, PC. 2016. Nat Genet 48, 1313-1320.
    doi: 10.1038/ng.3674PMID:27643537
  9. ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters. Bailey, SD, Zhang, X, Desai, K, Aid, M, Corradin, O, Cowper-Sal Lari, R, Akhtar-Zaidi, B, Scacheri, PC, Haibe-Kains, B, Lupien, M et al.. 2015. Nat Commun 2, 6186.
    doi: 10.1038/ncomms7186PMID:25645053
  10. Long ncRNA expression associates with tissue-specific enhancers. Vučićević, D, Corradin, O, Ntini, E, Scacheri, PC, Ørom, UA. 2015. Cell Cycle 14, 253-60.
    doi: 10.4161/15384101.2014.977641PMID:25607649
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Photo credit: Gretchen Ertl