David Housman

David Housman

Virginia and D.K. Ludwig Scholar for Cancer Research

David Housman studies the biological underpinnings of diseases like Huntington’s, cancer, and cardiovascular disease.





Elizabeth Galoyan



Assistant Phone


PhD 1971, Brandeis University

Research Summary

We use genetic approaches to identify the molecular basis of human disease pathology. More specifically, we develop strategies to combat three major disease areas: cancer, trinucleotide repeat disorders like Huntington’s disease, and cardiovascular disease.


  • National Academy of Medicine, Member, 1997
  • National Academy of Sciences, Member, 1994

Key Publications

  1. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Lowe, SW, Ruley, HE, Jacks, T, Housman, DE. 1993. Cell 74, 957-67.
  2. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member. Brook, JD, McCurrach, ME, Harley, HG, Buckler, AJ, Church, D, Aburatani, H, Hunter, K, Stanton, VP, Thirion, JP, Hudson, T. 1992. Cell 68, 799-808.
  3. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Call, KM, Glaser, T, Ito, CY, Buckler, AJ, Pelletier, J, Haber, DA, Rose, EA, Kral, A, Yeger, H, Lewis, WH. 1990. Cell 60, 509-20.
  4. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Lichter, P, Tang, CJ, Call, K, Hermanson, G, Evans, GA, Housman, D, Ward, DC. 1990. Science 247, 64-9.
  5. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Geissler, EN, Ryan, MA, Housman, DE. 1988. Cell 55, 185-92.

Recent Publications

More Publications
Photo courtesy of David Housman