Education
- MD, 1967, University of Munich
Research Summary
We aim to understand the epigenetic regulation of gene expression in mammalian development and disease. Embryonic stem cells are important because they have the potential to generate any cell type in the body and, therefore, have great potential for regenerative medicine. We study the way somatic cells reprogram to an embryonic pluripotent state, and use patient specific pluripotent cells to study complex human diseases.Awards
- German Society for Biochemistry and Molecular Biology, Otto Warburg Medal, 2014
- New York Academy, Medicine Medal, 2013
- Franklin Institute, Benjamin Franklin Medal, 2013
- National Science Foundation, National Medal of Science, 2011
- National Science Foundation, National Medal of Science, 2010
- National Academy of Sciences, Member, 2003
Key Publications
- Editing DNA Methylation in the Mammalian Genome. Liu, XS, Wu, H, Ji, X, Stelzer, Y, Wu, X, Czauderna, S, Shu, J, Dadon, D, Young, RA, Jaenisch, R et al.. 2016. Cell 167, 233-247.e17.
doi: 10.1016/j.cell.2016.08.056PMID:27662091 - Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Soldner, F, Stelzer, Y, Shivalila, CS, Abraham, BJ, Latourelle, JC, Barrasa, MI, Goldmann, J, Myers, RH, Young, RA, Jaenisch, R et al.. 2016. Nature 533, 95-9.
doi: 10.1038/nature17939PMID:27096366 - One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Wang, H, Yang, H, Shivalila, CS, Dawlaty, MM, Cheng, AW, Zhang, F, Jaenisch, R. 2013. Cell 153, 910-8.
doi: 10.1016/j.cell.2013.04.025PMID:23643243 - In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Wernig, M, Meissner, A, Foreman, R, Brambrink, T, Ku, M, Hochedlinger, K, Bernstein, BE, Jaenisch, R. 2007. Nature 448, 318-24.
doi: 10.1038/nature05944PMID:17554336 - Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Hochedlinger, K, Jaenisch, R. 2002. Nature 415, 1035-8.
doi: 10.1038/nature718PMID:11875572
Recent Publications
- MeCP2 links heterochromatin condensates and neurodevelopmental disease. Li, CH, Coffey, EL, Dall'Agnese, A, Hannett, NM, Tang, X, Henninger, JE, Platt, JM, Oksuz, O, Zamudio, AV, Afeyan, LK et al.. 2020. Nature , .
doi: 10.1038/s41586-020-2574-4PMID:32698189 - Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. Murai, N, Mitalipova, M, Jaenisch, R. 2020. Eur. J. Neurosci. , .
doi: 10.1111/ejn.14879PMID:32579729 - Intravital imaging of mouse embryos. Huang, Q, Cohen, MA, Alsina, FC, Devlin, G, Garrett, A, McKey, J, Havlik, P, Rakhilin, N, Wang, E, Xiang, K et al.. 2020. Science 368, 181-186.
doi: 10.1126/science.aba0210PMID:32273467 - Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras. Cohen, MA, Zhang, S, Sengupta, S, Ma, H, Bell, GW, Horton, B, Sharma, B, George, RE, Spranger, S, Jaenisch, R et al.. 2020. Cell Stem Cell 26, 579-592.e6.
doi: 10.1016/j.stem.2020.02.001PMID:32142683 - Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain. Svoboda, DS, Barrasa, MI, Shu, J, Rietjens, R, Zhang, S, Mitalipova, M, Berube, P, Fu, D, Shultz, LD, Bell, GW et al.. 2019. Proc. Natl. Acad. Sci. U.S.A. 116, 25293-25303.
doi: 10.1073/pnas.1913541116PMID:31772018 - Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Song, Y, van den Berg, PR, Markoulaki, S, Soldner, F, Dall'Agnese, A, Henninger, JE, Drotar, J, Rosenau, N, Cohen, MA, Young, RA et al.. 2019. Mol. Cell 75, 905-920.e6.
doi: 10.1016/j.molcel.2019.06.045PMID:31422875 - Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice. Tang, X, Drotar, J, Li, K, Clairmont, CD, Brumm, AS, Sullins, AJ, Wu, H, Liu, XS, Wang, J, Gray, NS et al.. 2019. Sci Transl Med 11, .
doi: 10.1126/scitranslmed.aau0164PMID:31366578 - Whsc1 links pluripotency exit with mesendoderm specification. Tian, TV, Di Stefano, B, Stik, G, Vila-Casadesús, M, Sardina, JL, Vidal, E, Dasti, A, Segura-Morales, C, De Andrés-Aguayo, L, Gómez, A et al.. 2019. Nat. Cell Biol. 21, 824-834.
doi: 10.1038/s41556-019-0342-1PMID:31235934 - Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Li, Y, Muffat, J, Omer Javed, A, Keys, HR, Lungjangwa, T, Bosch, I, Khan, M, Virgilio, MC, Gehrke, L, Sabatini, DM et al.. 2019. Proc. Natl. Acad. Sci. U.S.A. 116, 9527-9532.
doi: 10.1073/pnas.1900867116PMID:31019072
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