Rudolf Jaenisch

Rudolf Jaenisch

Professor of Biology; Member, Whitehead Institute; Member, Institute of Medicine

Rudolf Jaenisch uses pluripotent cells (ES and iPS cells) to study the genetic and epigenetic basis of human diseases such as Parkinson’s, Alzheimer’s, autism and cancer.





Robert Burger



Assistant Phone


  • MD, 1967, University of Munich

Research Summary

We aim to understand the epigenetic regulation of gene expression in mammalian development and disease. Embryonic stem cells are important because they have the potential to generate any cell type in the body and, therefore, have great potential for regenerative medicine. We study the way somatic cells reprogram to an embryonic pluripotent state, and use patient specific pluripotent cells to study complex human diseases.


  • German Society for Biochemistry and Molecular Biology, Otto Warburg Medal, 2014
  • New York Academy, Medicine Medal, 2013
  • Franklin Institute, Benjamin Franklin Medal, 2013
  • National Science Foundation, National Medal of Science, 2011
  • National Science Foundation, National Medal of Science, 2010
  • National Academy of Sciences, Member, 2003

Key Publications

Recent Publications

  1. Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Zhang, L, Richards, A, Barrasa, MI, Hughes, SH, Young, RA, Jaenisch, R. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2105968118PMID:33958444
  2. Response to "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Yang, H, Wang, H, Jaenisch, R. 2021. Genome Biol 22, 98.
    doi: 10.1186/s13059-021-02312-3PMID:33827646
  3. The role of GABAergic signalling in neurodevelopmental disorders. Tang, X, Jaenisch, R, Sur, M. 2021. Nat Rev Neurosci 22, 290-307.
    doi: 10.1038/s41583-021-00443-xPMID:33772226
  4. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Trapecar, M, Wogram, E, Svoboda, D, Communal, C, Omer, A, Lungjangwa, T, Sphabmixay, P, Velazquez, J, Schneider, K, Wright, CW et al.. 2021. Sci Adv 7, .
    doi: 10.1126/sciadv.abd1707PMID:33514545
  5. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Carlone, DL, Riba-Wolman, RD, Deary, LT, Tovaglieri, A, Jiang, L, Ambruzs, DM, Mead, BE, Shah, MS, Lengner, CJ, Jaenisch, R et al.. 2021. Stem Cells 39, 296-305.
    doi: 10.1002/stem.3318PMID:33438789
  6. In situ genome sequencing resolves DNA sequence and structure in intact biological samples. Payne, AC, Chiang, ZD, Reginato, PL, Mangiameli, SM, Murray, EM, Yao, CC, Markoulaki, S, Earl, AS, Labade, AS, Jaenisch, R et al.. 2021. Science 371, .
    doi: 10.1126/science.aay3446PMID:33384301
  7. Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction. Ma, H, Jeppesen, JF, Jaenisch, R. 2020. Cell Rep Med 1, 100097.
    doi: 10.1016/j.xcrm.2020.100097PMID:33205073
  8. Engineered tissues and strategies to overcome challenges in drug development. Khalil, AS, Jaenisch, R, Mooney, DJ. 2020. Adv Drug Deliv Rev 158, 116-139.
    doi: 10.1016/j.addr.2020.09.012PMID:32987094
  9. MeCP2 links heterochromatin condensates and neurodevelopmental disease. Li, CH, Coffey, EL, Dall'Agnese, A, Hannett, NM, Tang, X, Henninger, JE, Platt, JM, Oksuz, O, Zamudio, AV, Afeyan, LK et al.. 2020. Nature 586, 440-444.
    doi: 10.1038/s41586-020-2574-4PMID:32698189
  10. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. Murai, N, Mitalipova, M, Jaenisch, R. 2020. Eur J Neurosci 52, 3667-3678.
    doi: 10.1111/ejn.14879PMID:32579729
More Publications





Photo credit: Gretchen Ertl/Whitehead Institute