Leonard P. Guarente

Leonard P. Guarente

Novartis Professor of Biology

Leonard P. Guarente looks at mammal, mouse, and human brains to understand the genetic underpinning of aging and age-related diseases like Alzheimer’s.

617-253-6965

Phone

68-280

Office

leng@mit.edu

Email

Mary Gallagher

Assistant

617-258-7360

Assistant Phone

Education

PhD 1978, Harvard University

Research Summary

We combine comprehensive bioinformatics analyses with functional analyses of pathways and genes to study aging in humans and mice. We apply these approaches to identify the major pathways and genes involved in the aging of certain brain regions. We are also studying muscular dystrophy and muscle loss with aging. Ultimately, our findings may guide studies in other organs and lead to a systemic understanding of mammalian aging.

Awards

  • Miami Winter Symposium, Feodor Lynen Award, 2012
  • University of Toronto, Charles H. Best Lectureship and Award, 2011
  • Dart/NYU Biotechnology, Achievement Award, 2009
  • French Academie des Sciences, Elected, 2009
  • American Academy of Arts and Sciences, Fellow, 2004

Key Publications

  1. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Picard, F, Kurtev, M, Chung, N, Topark-Ngarm, A, Senawong, T, Machado De Oliveira, R, Leid, M, McBurney, MW, Guarente, L. 2004. Nature 429, 771-6.
    doi: 10.1038/nature02583PMID:15175761
  2. Mammalian SIRT1 represses forkhead transcription factors. Motta, MC, Divecha, N, Lemieux, M, Kamel, C, Chen, D, Gu, W, Bultsma, Y, McBurney, M, Guarente, L. 2004. Cell 116, 551-63.
    PMID:14980222
  3. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Tissenbaum, HA, Guarente, L. 2001. Nature 410, 227-30.
    doi: 10.1038/35065638PMID:11242085
  4. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Imai, S, Armstrong, CM, Kaeberlein, M, Guarente, L. 2000. Nature 403, 795-800.
    doi: 10.1038/35001622PMID:10693811
  5. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Kaeberlein, M, McVey, M, Guarente, L. 1999. Genes Dev. 13, 2570-80.
    PMID:10521401

Recent Publications

  1. SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. Herskovits, AZ, Hunter, TA, Maxwell, N, Pereira, K, Whittaker, CA, Valdez, G, Guarente, LP. 2018. Aging Cell , e12839.
    doi: 10.1111/acel.12839PMID:30295421
  2. It takes two to tango: NAD+ and sirtuins in aging/longevity control. Imai, SI, Guarente, L. 2016. NPJ Aging Mech Dis 2, 16017.
    doi: 10.1038/npjamd.2016.17PMID:28721271
  3. The brain, sirtuins, and ageing. Satoh, A, Imai, SI, Guarente, L. 2017. Nat. Rev. Neurosci. 18, 362-374.
    doi: 10.1038/nrn.2017.42PMID:28515492
  4. Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. Williams, EO, Taylor, AK, Bell, EL, Lim, R, Kim, DM, Guarente, L. 2016. Cell Rep 17, 809-820.
    doi: 10.1016/j.celrep.2016.09.046PMID:27732856
  5. CELL METABOLISM. The resurgence of NAD⁺. Guarente, L. 2016. Science 352, 1396-7.
    doi: 10.1126/science.aag1718PMID:27313027
  6. The multifaceted functions of sirtuins in cancer. Chalkiadaki, A, Guarente, L. 2015. Nat. Rev. Cancer 15, 608-24.
    doi: 10.1038/nrc3985PMID:26383140
  7. SirT1 is required in the male germ cell for differentiation and fecundity in mice. Bell, EL, Nagamori, I, Williams, EO, Del Rosario, AM, Bryson, BD, Watson, N, White, FM, Sassone-Corsi, P, Guarente, L. 2014. Development 141, 3495-504.
    doi: 10.1242/dev.110627PMID:25142464
  8. Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. Chalkiadaki, A, Igarashi, M, Nasamu, AS, Knezevic, J, Guarente, L. 2014. PLoS Genet. 10, e1004490.
    doi: 10.1371/journal.pgen.1004490PMID:25032964
  9. SnapShot: sirtuins, NAD, and aging. Nakagawa, T, Guarente, L. 2014. Cell Metab. 20, 192-192.e1.
    doi: 10.1016/j.cmet.2014.06.001PMID:24988458
  10. NAD+ and sirtuins in aging and disease. Imai, S, Guarente, L. 2014. Trends Cell Biol. 24, 464-71.
    doi: 10.1016/j.tcb.2014.04.002PMID:24786309
More Publications

Multimedia