Leonard P. Guarente

Leonard P. Guarente

Novartis Professor of Biology

Leonard P. Guarente looks at mammal, mouse, and human brains to understand the genetic underpinning of aging and age-related diseases like Alzheimer’s.







Mary Gallagher



Assistant Phone


PhD 1978, Harvard University

Research Summary

We combine comprehensive bioinformatics analyses with functional analyses of pathways and genes to study aging in humans and mice. We apply these approaches to identify the major pathways and genes involved in the aging of certain brain regions. We are also studying muscular dystrophy and muscle loss with aging. Ultimately, our findings may guide studies in other organs and lead to a systemic understanding of mammalian aging.


  • Miami Winter Symposium, Feodor Lynen Award, 2012
  • University of Toronto, Charles H. Best Lectureship and Award, 2011
  • Dart/NYU Biotechnology, Achievement Award, 2009
  • French Academie des Sciences, Elected, 2009
  • American Academy of Arts and Sciences, Fellow, 2004

Key Publications

  1. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Picard, F, Kurtev, M, Chung, N, Topark-Ngarm, A, Senawong, T, Machado De Oliveira, R, Leid, M, McBurney, MW, Guarente, L. 2004. Nature 429, 771-6.
    doi: 10.1038/nature02583PMID:15175761
  2. Mammalian SIRT1 represses forkhead transcription factors. Motta, MC, Divecha, N, Lemieux, M, Kamel, C, Chen, D, Gu, W, Bultsma, Y, McBurney, M, Guarente, L. 2004. Cell 116, 551-63.
  3. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Tissenbaum, HA, Guarente, L. 2001. Nature 410, 227-30.
    doi: 10.1038/35065638PMID:11242085
  4. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Imai, S, Armstrong, CM, Kaeberlein, M, Guarente, L. 2000. Nature 403, 795-800.
    doi: 10.1038/35001622PMID:10693811
  5. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Kaeberlein, M, McVey, M, Guarente, L. 1999. Genes Dev. 13, 2570-80.

Recent Publications

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