Leonard P. Guarente

Leonard P. Guarente

Novartis Professor of Biology

Leonard P. Guarente looks at mammal, mouse, and human brains to understand the genetic underpinning of aging and age-related diseases like Alzheimer’s.







Mary Gallagher



Assistant Phone


  • PhD, 1978, Harvard University
  • SB, 1974, Biology, MIT

Research Summary

We combine comprehensive bioinformatics analyses with functional analyses of pathways and genes to study aging in humans and mice. We apply these approaches to identify the major pathways and genes involved in the aging of certain brain regions. We are also studying muscular dystrophy and muscle loss with aging. Ultimately, our findings may guide studies in other organs and lead to a systemic understanding of mammalian aging.


  • Miami Winter Symposium, Feodor Lynen Award, 2012
  • University of Toronto, Charles H. Best Lectureship and Award, 2011
  • Dart/NYU Biotechnology, Achievement Award, 2009
  • French Academie des Sciences, Elected, 2009
  • American Academy of Arts and Sciences, Fellow, 2004

Key Publications

Recent Publications

  1. Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease. Glorioso, CA, Pfenning, AR, Lee, SS, Bennett, DA, Sibille, EL, Kellis, M, Guarente, LP. 2019. Life Sci Alliance 2, .
    doi: 10.26508/lsa.201900303PMID:31133613
  2. SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis. Herskovits, AZ, Hunter, TA, Maxwell, N, Pereira, K, Whittaker, CA, Valdez, G, Guarente, LP. 2018. Aging Cell 17, e12839.
    doi: 10.1111/acel.12839PMID:30295421
  3. It takes two to tango: NAD+ and sirtuins in aging/longevity control. Imai, SI, Guarente, L. 2016. NPJ Aging Mech Dis 2, 16017.
    doi: 10.1038/npjamd.2016.17PMID:28721271
  4. The brain, sirtuins, and ageing. Satoh, A, Imai, SI, Guarente, L. 2017. Nat. Rev. Neurosci. 18, 362-374.
    doi: 10.1038/nrn.2017.42PMID:28515492
  5. Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. Williams, EO, Taylor, AK, Bell, EL, Lim, R, Kim, DM, Guarente, L. 2016. Cell Rep 17, 809-820.
    doi: 10.1016/j.celrep.2016.09.046PMID:27732856
  6. CELL METABOLISM. The resurgence of NAD⁺. Guarente, L. 2016. Science 352, 1396-7.
    doi: 10.1126/science.aag1718PMID:27313027
  7. The multifaceted functions of sirtuins in cancer. Chalkiadaki, A, Guarente, L. 2015. Nat. Rev. Cancer 15, 608-24.
    doi: 10.1038/nrc3985PMID:26383140
  8. SirT1 is required in the male germ cell for differentiation and fecundity in mice. Bell, EL, Nagamori, I, Williams, EO, Del Rosario, AM, Bryson, BD, Watson, N, White, FM, Sassone-Corsi, P, Guarente, L. 2014. Development 141, 3495-504.
    doi: 10.1242/dev.110627PMID:25142464
  9. Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. Chalkiadaki, A, Igarashi, M, Nasamu, AS, Knezevic, J, Guarente, L. 2014. PLoS Genet. 10, e1004490.
    doi: 10.1371/journal.pgen.1004490PMID:25032964
  10. SnapShot: sirtuins, NAD, and aging. Nakagawa, T, Guarente, L. 2014. Cell Metab. 20, 192-192.e1.
    doi: 10.1016/j.cmet.2014.06.001PMID:24988458
More Publications