Education
- PhD, 2011, MIT
- BS, 2006, Chemistry, University of Puerto Rico-Río Piedras
Research Summary
We focus on the molecular entities controlling and coordinating RNA metabolism — that is, the compendium of processes that involve RNA, including protein synthesis, processing, modifications, export, translation and degradation. Our goal is to understand how different aspects of RNA metabolism are controlled to generate structure and function during development, as well as how mutations in components of the RNA metabolic program lead to congenital disorders and cancer.Key Publications
- 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat. Struct. Mol. Biol. 23, 231-8.
doi: 10.1038/nsmb.3176PMID:26878240 - RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
doi: 10.1038/nature13923PMID:25470060 - Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol. Cell 49, 825-37.
doi: 10.1016/j.molcel.2013.01.038PMID:23473601 - Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
doi: 10.1038/nature09264PMID:20686481
Recent Publications
- Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Calo, E, Gu, B, Bowen, ME, Aryan, F, Zalc, A, Liang, J, Flynn, RA, Swigut, T, Chang, HY, Attardi, LD et al.. 2018. Nature 554, 112-117.
doi: 10.1038/nature25449PMID:29364875 - 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat. Struct. Mol. Biol. 23, 231-8.
doi: 10.1038/nsmb.3176PMID:26878240 - RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
doi: 10.1038/nature13923PMID:25470060 - The retinoblastoma protein induces apoptosis directly at the mitochondria. Hilgendorf, KI, Leshchiner, ES, Nedelcu, S, Maynard, MA, Calo, E, Ianari, A, Walensky, LD, Lees, JA. 2013. Genes Dev. 27, 1003-15.
doi: 10.1101/gad.211326.112PMID:23618872 - Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol. Cell 49, 825-37.
doi: 10.1016/j.molcel.2013.01.038PMID:23473601 - An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Pritchard, CD, O'Shea, TM, Siegwart, DJ, Calo, E, Anderson, DG, Reynolds, FM, Thomas, JA, Slotkin, JR, Woodard, EJ, Langer, R. 2011. Biomaterials 32, 587-97.
doi: 10.1016/j.biomaterials.2010.08.106PMID:20880573 - Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
doi: 10.1038/nature09264PMID:20686481 - Proapoptotic function of the retinoblastoma tumor suppressor protein. Ianari, A, Natale, T, Calo, E, Ferretti, E, Alesse, E, Screpanti, I, Haigis, K, Gulino, A, Lees, JA. 2009. Cancer Cell 15, 184-94.
doi: 10.1016/j.ccr.2009.01.026PMID:19249677 - Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Berman, SD, Calo, E, Landman, AS, Danielian, PS, Miller, ES, West, JC, Fonhoue, BD, Caron, A, Bronson, R, Bouxsein, ML et al.. 2008. Proc. Natl. Acad. Sci. U.S.A. 105, 11851-6.
doi: 10.1073/pnas.0805462105PMID:18697945