Eliezer Calo

Eliezer Calo

Irwin W. and Helen Sizer Career Development Assistant Professor

Eliezer Calo studies how cells build ribosomes and how dysfunction in ribosome biogenesis and function leads to tissue-specific developmental disorders and cancer.

617-324-5330

Phone

68-270

Office

calo@mit.edu

Email

Cindy Woolley

Assistant

617-253-6060

Assistant Phone

Education

PhD 2011, Massachusetts Institute of Technology

Research Summary

We focus on the molecular entities controlling and coordinating RNA metabolism — that is, the compendium of processes that involve RNA, including protein synthesis, processing, modifications, export, translation and degradation. Our goal is to understand how different aspects of RNA metabolism are controlled to generate structure and function during development, as well as how mutations in components of the RNA metabolic program lead to congenital disorders and cancer.

Key Publications

  1. 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat. Struct. Mol. Biol. 23, 231-8.
    doi: 10.1038/nsmb.3176PMID:26878240
  2. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
    doi: 10.1038/nature13923PMID:25470060
  3. Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol. Cell 49, 825-37.
    doi: 10.1016/j.molcel.2013.01.038PMID:23473601
  4. Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
    doi: 10.1038/nature09264PMID:20686481

Recent Publications

  1. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Calo, E, Gu, B, Bowen, ME, Aryan, F, Zalc, A, Liang, J, Flynn, RA, Swigut, T, Chang, HY, Attardi, LD et al.. 2018. Nature 554, 112-117.
    doi: 10.1038/nature25449PMID:29364875
  2. 7SK-BAF axis controls pervasive transcription at enhancers. Flynn, RA, Do, BT, Rubin, AJ, Calo, E, Lee, B, Kuchelmeister, H, Rale, M, Chu, C, Kool, ET, Wysocka, J et al.. 2016. Nat. Struct. Mol. Biol. 23, 231-8.
    doi: 10.1038/nsmb.3176PMID:26878240
  3. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Calo, E, Flynn, RA, Martin, L, Spitale, RC, Chang, HY, Wysocka, J. 2015. Nature 518, 249-53.
    doi: 10.1038/nature13923PMID:25470060
  4. The retinoblastoma protein induces apoptosis directly at the mitochondria. Hilgendorf, KI, Leshchiner, ES, Nedelcu, S, Maynard, MA, Calo, E, Ianari, A, Walensky, LD, Lees, JA. 2013. Genes Dev. 27, 1003-15.
    doi: 10.1101/gad.211326.112PMID:23618872
  5. Modification of enhancer chromatin: what, how, and why? Calo, E, Wysocka, J. 2013. Mol. Cell 49, 825-37.
    doi: 10.1016/j.molcel.2013.01.038PMID:23473601
  6. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Pritchard, CD, O'Shea, TM, Siegwart, DJ, Calo, E, Anderson, DG, Reynolds, FM, Thomas, JA, Slotkin, JR, Woodard, EJ, Langer, R et al.. 2011. Biomaterials 32, 587-97.
    doi: 10.1016/j.biomaterials.2010.08.106PMID:20880573
  7. Rb regulates fate choice and lineage commitment in vivo. Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA. 2010. Nature 466, 1110-4.
    doi: 10.1038/nature09264PMID:20686481
  8. Proapoptotic function of the retinoblastoma tumor suppressor protein. Ianari, A, Natale, T, Calo, E, Ferretti, E, Alesse, E, Screpanti, I, Haigis, K, Gulino, A, Lees, JA. 2009. Cancer Cell 15, 184-94.
    doi: 10.1016/j.ccr.2009.01.026PMID:19249677
  9. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Berman, SD, Calo, E, Landman, AS, Danielian, PS, Miller, ES, West, JC, Fonhoue, BD, Caron, A, Bronson, R, Bouxsein, ML et al.. 2008. Proc. Natl. Acad. Sci. U.S.A. 105, 11851-6.
    doi: 10.1073/pnas.0805462105PMID:18697945
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