EducationPhD 1976, California Institute of Technology
Research SummaryWe use genetic, biochemical, physiologic, chemical, cellular and molecular biological methods to study cell surface receptor structure and function. We focus on lipoprotein receptors — in particular, the High Density Lipoprotein (HDL) receptor called Scavenger Receptor, Class B, Type I (SR-BI). Our analyses have provided insight into basic biological processes, contributed to our understanding of atherosclerosis and coronary heart disease (CHD) and have uncovered an unexpected connection between cholesterol and mammalian female infertility.
- Tulane University School of Science and Engineering Outstanding Alumnus Award, 2010
- National Academy of Sciences, Member, 2009
- Outstanding Achievement Award for Contributions to Atherosclerosis Research, International Atherosclerosis Society, 2009
- Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar, D, Oka, T, Brittle, EE, Vasile, E, Lupashin, VV, Chatterton, JE, Heuser, JE, Krieger, M, Waters, MG. 2002. J. Cell Biol. 157, 405-15.
- Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Braun, A, Trigatti, BL, Post, MJ, Sato, K, Simons, M, Edelberg, JM, Rosenberg, RD, Schrenzel, M, Krieger, M. 2002. Circ. Res. 90, 270-6.
- Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Acton, S, Rigotti, A, Landschulz, KT, Xu, S, Hobbs, HH, Krieger, M. 1996. Science 271, 518-20.
- Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama, T, Freeman, M, Rohrer, L, Zabrecky, J, Matsudaira, P, Krieger, M. 1990. Nature 343, 531-5.
- Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Kozarsky, K, Kingsley, D, Krieger, M. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 4335-9.