Monty Krieger

Monty Krieger

Whitehead Professor of Molecular Genetics; MacVicar Faculty Fellow

Monty Krieger studies cell surface receptors and cholesterol and their impact on normal physiology and diseases, such as heart disease and infertility.





Cindy Woolley



Assistant Phone


PhD 1976, California Institute of Technology

Research Summary

We use genetic, biochemical, physiologic, chemical, cellular and molecular biological methods to study cell surface receptor structure and function. We focus on lipoprotein receptors — in particular, the High Density Lipoprotein (HDL) receptor called Scavenger Receptor, Class B, Type I (SR-BI). Our analyses have provided insight into basic biological processes, contributed to our understanding of atherosclerosis and coronary heart disease (CHD) and have uncovered an unexpected connection between cholesterol and mammalian female infertility.


  • Tulane University School of Science and Engineering Outstanding Alumnus Award, 2010
  • National Academy of Sciences, Member, 2009
  • Outstanding Achievement Award for Contributions to Atherosclerosis Research, International Atherosclerosis Society, 2009

Key Publications

  1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar, D, Oka, T, Brittle, EE, Vasile, E, Lupashin, VV, Chatterton, JE, Heuser, JE, Krieger, M, Waters, MG. 2002. J. Cell Biol. 157, 405-15.
    doi: 10.1083/jcb.200202016PMID: 11980916
  2. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Braun, A, Trigatti, BL, Post, MJ, Sato, K, Simons, M, Edelberg, JM, Rosenberg, RD, Schrenzel, M, Krieger, M. 2002. Circ. Res. 90, 270-6.
    PMID: 11861414
  3. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Acton, S, Rigotti, A, Landschulz, KT, Xu, S, Hobbs, HH, Krieger, M. 1996. Science 271, 518-20.
    PMID: 8560269
  4. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama, T, Freeman, M, Rohrer, L, Zabrecky, J, Matsudaira, P, Krieger, M. 1990. Nature 343, 531-5.
    doi: 10.1038/343531a0PMID: 2300204
  5. Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Kozarsky, K, Kingsley, D, Krieger, M. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 4335-9.
    PMID: 3380796

Recent Publications

  1. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. PrabhuDas, MR, Baldwin, CL, Bollyky, PL, Bowdish, DME, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J et al.. 2017. J. Immunol. 198, 3775-3789.
    doi: 10.4049/jimmunol.1700373PMID: 28483986
  2. Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Pal, R, Ke, Q, Pihan, GA, Yesilaltay, A, Penman, ML, Wang, L, Chitraju, C, Kang, PM, Krieger, M, Kocher, O. 2016. Am. J. Physiol. Heart Circ. Physiol. 311, H1392-H1408.
    doi: 10.1152/ajpheart.00463.2016PMID: 27694217
  3. Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport. Dockendorff, C, Faloon, PW, Yu, M, Youngsaye, W, Penman, M, Nieland, TJ, Nag, PP, Lewis, TA, Pu, J, Bennion, M et al.. 2015. ACS Med Chem Lett 6, 375-380.
    doi: 10.1021/ml500154qPMID: 26478787
  4. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Dockendorff, C, Faloon, PW, Germain, A, Yu, M, Youngsaye, W, Nag, PP, Bennion, M, Penman, M, Nieland, TJ, Dandapani, S et al.. 2015. Bioorg. Med. Chem. Lett. 25, 2594-8.
    doi: 10.1016/j.bmcl.2015.03.074PMID: 25958245
  5. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Dockendorff, C, Faloon, PW, Pu, J, Yu, M, Johnston, S, Bennion, M, Penman, M, Nieland, TJ, Dandapani, S, Perez, JR et al.. 2015. Bioorg. Med. Chem. Lett. 25, 2100-5.
    doi: 10.1016/j.bmcl.2015.03.073PMID: 25900219
  6. Excess cholesterol induces mouse egg activation and may cause female infertility. Yesilaltay, A, Dokshin, GA, Busso, D, Wang, L, Galiani, D, Chavarria, T, Vasile, E, Quilaqueo, L, Orellana, JA, Walzer, D et al.. 2014. Proc. Natl. Acad. Sci. U.S.A. 111, E4972-80.
    doi: 10.1073/pnas.1418954111PMID: 25368174
  7. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Tsukamoto, K, Mani, DR, Shi, J, Zhang, S, Haagensen, DE, Otsuka, F, Guan, J, Smith, JD, Weng, W, Liao, R et al.. 2013. Proc. Natl. Acad. Sci. U.S.A. 110, 17023-8.
    doi: 10.1073/pnas.1315986110PMID: 24082102
  8. Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. Tsukamoto, K, Buck, L, Inman, W, Griffith, L, Kocher, O, Krieger, M. 2013. PLoS ONE 8, e69725.
    doi: 10.1371/journal.pone.0069725PMID: 23936087
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