Richard A. Young

Richard A. Young

Professor of Biology; Member, Whitehead Institute

Richard A. Young explores how and why gene expression differs in healthy versus diseased cells.

617-258-5218

Phone

WI-501

Office

Katie Lazuk

Assistant

617-258-5219

Assistant Phone

Education

  • PhD, 1979, Yale University
  • BS, 1975, Biological Sciences, Indiana University

Research Summary

We use experimental and computational technologies to determine how signaling pathways, transcription factors, chromatin regulators and small RNAs regulate gene expression in healthy and diseased cells. Our interests range from the basic molecular mechanisms behind gene control to drug development for cancer and other diseases caused by gene misregulation.

Awards

  • National Academy of Sciences, Member, 2012

Key Publications

  1. A Phase Separation Model for Transcriptional Control. Hnisz, D, Shrinivas, K, Young, RA, Chakraborty, AK, Sharp, PA. 2017. Cell 169, 13-23.
    doi: 10.1016/j.cell.2017.02.007PMID:28340338
  2. Transcriptional Addiction in Cancer. Bradner, JE, Hnisz, D, Young, RA. 2017. Cell 168, 629-643.
    doi: 10.1016/j.cell.2016.12.013PMID:28187285
  3. Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Hnisz, D, Day, DS, Young, RA. 2016. Cell 167, 1188-1200.
    doi: 10.1016/j.cell.2016.10.024PMID:27863240
  4. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Hnisz, D, Weintraub, AS, Day, DS, Valton, AL, Bak, RO, Li, CH, Goldmann, J, Lajoie, BR, Fan, ZP, Sigova, AA et al.. 2016. Science 351, 1454-1458.
    doi: 10.1126/science.aad9024PMID:26940867
  5. Transcription factor trapping by RNA in gene regulatory elements. Sigova, AA, Abraham, BJ, Ji, X, Molinie, B, Hannett, NM, Guo, YE, Jangi, M, Giallourakis, CC, Sharp, PA, Young, RA. 2015. Science 350, 978-81.
    doi: 10.1126/science.aad3346PMID:26516199

Recent Publications

  1. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Boija, A, Klein, IA, Sabari, BR, Dall'Agnese, A, Coffey, EL, Zamudio, AV, Li, CH, Shrinivas, K, Manteiga, JC, Hannett, NM et al.. 2018. Cell 175, 1842-1855.e16.
    doi: 10.1016/j.cell.2018.10.042PMID:30449618
  2. Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Whyte, WA, Bilodeau, S, Orlando, DA, Hoke, HA, Frampton, GM, Foster, CT, Cowley, SM, Young, RA. 2018. Nature 562, E24.
    doi: 10.1038/s41586-018-0487-2PMID:30209401
  3. Coactivator condensation at super-enhancers links phase separation and gene control. Sabari, BR, Dall'Agnese, A, Boija, A, Klein, IA, Coffey, EL, Shrinivas, K, Abraham, BJ, Hannett, NM, Zamudio, AV, Manteiga, JC et al.. 2018. Science 361, .
    doi: 10.1126/science.aar3958PMID:29930091
  4. Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism. Schuijers, J, Manteiga, JC, Weintraub, AS, Day, DS, Zamudio, AV, Hnisz, D, Lee, TI, Young, RA. 2018. Cell Rep 23, 349-360.
    doi: 10.1016/j.celrep.2018.03.056PMID:29641996
  5. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Weintraub, AS, Li, CH, Zamudio, AV, Sigova, AA, Hannett, NM, Day, DS, Abraham, BJ, Cohen, MA, Nabet, B, Buckley, DL et al.. 2017. Cell 171, 1573-1588.e28.
    doi: 10.1016/j.cell.2017.11.008PMID:29224777
  6. New Insights into Genome Structure: Genes of a Feather Stick Together. Hnisz, D, Young, RA. 2017. Mol. Cell 67, 730-731.
    doi: 10.1016/j.molcel.2017.08.023PMID:28886334
  7. Transcriptional Addiction in Cancer. Bradner, JE, Hnisz, D, Young, RA. 2017. Cell 168, 629-643.
    doi: 10.1016/j.cell.2016.12.013PMID:28187285
  8. Small genomic insertions form enhancers that misregulate oncogenes. Abraham, BJ, Hnisz, D, Weintraub, AS, Kwiatkowski, N, Li, CH, Li, Z, Weichert-Leahey, N, Rahman, S, Liu, Y, Etchin, J et al.. 2017. Nat Commun 8, 14385.
    doi: 10.1038/ncomms14385PMID:28181482
  9. Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Hnisz, D, Day, DS, Young, RA. 2016. Cell 167, 1188-1200.
    doi: 10.1016/j.cell.2016.10.024PMID:27863240
  10. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Hnisz, D, Weintraub, AS, Day, DS, Valton, AL, Bak, RO, Li, CH, Goldmann, J, Lajoie, BR, Fan, ZP, Sigova, AA et al.. 2016. Science 351, 1454-1458.
    doi: 10.1126/science.aad9024PMID:26940867
More Publications

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Photo credit: Gretchen Ertl/Whitehead Institute