Martha Constantine-Paton uses a combination of classical and modern genetic tools in mice to study the contributions of specific brain regions to normal behavior.
Frank B. Gertler considers the role of cell shape and movement in developmental defects and diseases.
H. Robert Horvitz analyzes the roles of genes in animal development and behavior, gaining insight into human disease.
Rudolf Jaenisch uses pluripotent cells (ES and iPS cells) to study the genetic and epigenetic basis of human diseases such as Parkinson’s, Alzheimer’s, autism and cancer.
Dennis Kim considers the relationship between animals and their microbial environment — specifically, how bacteria influence the behavior and physiology of the simple animal host C. elegans.
Troy Littleton is interested in how neuronal connections form and function, and how neurological disease disrupts synaptic communication.
Elly Nedivi studies the mechanisms underlying brain circuit plasticity — characterizing the genes and proteins involved, as well as visualizing synaptic and neuronal remodeling in the living mouse brain.
Edward Scolnick has provided critical insights into the genetic underpinnings of a variety of psychiatric disorders, including bipolar disorder, schizophrenia, and autism.
Hazel Sive studies fundamental mechanisms underlying vertebrate face and brain formation, as well as the molecular underpinnings for neurodevelopmental disorders.
Susumu Tonegawa investigates the biological underpinnings of learning and memory in rodents.
Matthew Wilson studies rodent learning and memory by recording and manipulating the activity of neurons during behavior and sleep.