Elly Nedivi

Elly Nedivi

William R. (1964) and Linda R. Young Professor of Neuroscience

Elly Nedivi studies the mechanisms underlying brain circuit plasticity — characterizing the genes and proteins involved, as well as visualizing synaptic and neuronal remodeling in the living mouse brain.

617-253-2344

Phone

46-3239

Office

Charles Moss

Assistant

617-452-2070

Assistant Phone

Education

  • PhD, 1991, Stanford University
  • BSc, 1982, Biology and Biochemistry, Hebrew University, Israel

Research Summary

The property of the brain that allows it to constantly adapt to change is termed plasticity, and is a prominent feature not only of learning and memory in the adult, but also of brain development. Connections between neurons (synapses) that are frequently used become stronger, while those that are unstimulated gradually dwindle away. The Nedivi lab works to identify the cellular mechanisms that underlie the addition and elimination of synaptic connections in response to activity using genetic and in vivo imaging approaches.

Awards

  • American Association for the Advancement of Science (AAAS), Fellow, 2016
  • AFAR Julie Martin Mid-Career Award in Aging Research, 2007 – 2011
  • Edgerly Innovation Fund Award, 2006
  • Dean’s Education and Student Advising Award, 2003
  • NSF Powre Award, 1999
  • Alfred P . Sloan Research Fellowship, 1999 – 2001
  • Ellison Medical Foundation New Scholar Award, 1997 – 2002

Recent Publications

  1. CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment. Subramanian, J, Michel, K, Benoit, M, Nedivi, E. 2019. Cell Rep 28, 1584-1595.e5.
    doi: 10.1016/j.celrep.2019.07.012PMID:31390571
  2. Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function. Rathje, M, Waxman, H, Benoit, M, Tammineni, P, Leu, C, Loebrich, S, Nedivi, E. 2019. Mol. Psychiatry , .
    doi: 10.1038/s41380-018-0314-zPMID:30610203
  3. Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline. Eavri, R, Shepherd, J, Welsh, CA, Flanders, GH, Bear, MF, Nedivi, E. 2018. J. Neurosci. 38, 8421-8432.
    doi: 10.1523/JNEUROSCI.0808-18.2018PMID:30108129
  4. Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites. Boivin, JR, Nedivi, E. 2018. Curr. Opin. Neurobiol. 51, 16-22.
    doi: 10.1016/j.conb.2018.01.013PMID:29454834
  5. Spine Dynamics: Are They All the Same? Berry, KP, Nedivi, E. 2017. Neuron 96, 43-55.
    doi: 10.1016/j.neuron.2017.08.008PMID:28957675
  6. Experience-Dependent Structural Plasticity in the Visual System. Berry, KP, Nedivi, E. 2016. Annu Rev Vis Sci 2, 17-35.
    doi: 10.1146/annurev-vision-111815-114638PMID:28532358
  7. Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo. Villa, KL, Berry, KP, Subramanian, J, Cha, JW, Oh, WC, Kwon, HB, Kubota, Y, So, PT, Nedivi, E. 2016. Neuron 89, 756-69.
    doi: 10.1016/j.neuron.2016.01.010PMID:26853302
  8. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Loebrich, S, Benoit, MR, Konopka, JA, Cottrell, JR, Gibson, J, Nedivi, E. 2016. Curr. Biol. 26, 296-308.
    doi: 10.1016/j.cub.2015.11.071PMID:26776730
  9. Genomic mapping and cellular expression of human CPG2 transcripts in the SYNE1 gene. Loebrich, S, Rathje, M, Hager, E, Ataman, B, Harmin, DA, Greenberg, ME, Nedivi, E. 2016. Mol. Cell. Neurosci. 71, 46-55.
    doi: 10.1016/j.mcn.2015.12.007PMID:26704904
  10. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Loebrich, S, Djukic, B, Tong, ZJ, Cottrell, JR, Turrigiano, GG, Nedivi, E. 2013. Proc. Natl. Acad. Sci. U.S.A. 110, E4548-56.
    doi: 10.1073/pnas.1318860110PMID:24191017
More Publications
Photo credit: Joshua Sarinana