Elly Nedivi

Elly Nedivi

Professor of Brain & Cognitive Sciences and Biology

Elly Nedivi studies the mechanisms underlying brain circuit plasticity — characterizing the genes and proteins involved, as well as visualizing synaptic and neuronal remodeling in the living mouse brain.

617-253-2344

Phone

46-3239

Office

Charles Moss

Assistant

617-452-2070

Assistant Phone

Education

PhD 1991, Stanford University

Research Summary

The property of the brain that allows it to constantly adapt to change is termed plasticity, and is a prominent feature not only of learning and memory in the adult, but also of brain development. Connections between neurons (synapses) that are frequently used become stronger, while those that are unstimulated gradually dwindle away. The Nedivi lab works to identify the cellular mechanisms that underlie the addition and elimination of synaptic connections in response to activity using genetic and in vivo imaging approaches.

Awards

  • American Association for the Advancement of Science (AAAS), Fellow, 2016
  • AFAR Julie Martin Mid-Career Award in Aging Research, 2007 – 2011
  • Edgerly Innovation Fund Award, 2006
  • Dean’s Education and Student Advising Award, 2003
  • NSF Powre Award, 1999
  • Alfred P . Sloan Research Fellowship, 1999 – 2001
  • Ellison Medical Foundation New Scholar Award, 1997 – 2002

Recent Publications

  1. Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline. Eavri, R, Shepherd, J, Welsh, CA, Flanders, GH, Bear, MF, Nedivi, E. 2018. J. Neurosci. 38, 8421-8432.
    doi: 10.1523/JNEUROSCI.0808-18.2018PMID:30108129
  2. Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites. Boivin, JR, Nedivi, E. 2018. Curr. Opin. Neurobiol. 51, 16-22.
    doi: 10.1016/j.conb.2018.01.013PMID:29454834
  3. Spine Dynamics: Are They All the Same? Berry, KP, Nedivi, E. 2017. Neuron 96, 43-55.
    doi: 10.1016/j.neuron.2017.08.008PMID:28957675
  4. Experience-Dependent Structural Plasticity in the Visual System. Berry, KP, Nedivi, E. 2016. Annu Rev Vis Sci 2, 17-35.
    doi: 10.1146/annurev-vision-111815-114638PMID:28532358
  5. Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo. Villa, KL, Berry, KP, Subramanian, J, Cha, JW, Oh, WC, Kwon, HB, Kubota, Y, So, PT, Nedivi, E. 2016. Neuron 89, 756-69.
    doi: 10.1016/j.neuron.2016.01.010PMID:26853302
  6. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Loebrich, S, Benoit, MR, Konopka, JA, Cottrell, JR, Gibson, J, Nedivi, E. 2016. Curr. Biol. 26, 296-308.
    doi: 10.1016/j.cub.2015.11.071PMID:26776730
  7. Genomic mapping and cellular expression of human CPG2 transcripts in the SYNE1 gene. Loebrich, S, Rathje, M, Hager, E, Ataman, B, Harmin, DA, Greenberg, ME, Nedivi, E. 2016. Mol. Cell. Neurosci. 71, 46-55.
    doi: 10.1016/j.mcn.2015.12.007PMID:26704904
  8. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Loebrich, S, Djukic, B, Tong, ZJ, Cottrell, JR, Turrigiano, GG, Nedivi, E. 2013. Proc. Natl. Acad. Sci. U.S.A. 110, E4548-56.
    doi: 10.1073/pnas.1318860110PMID:24191017
  9. Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex. Chen, JL, Villa, KL, Cha, JW, So, PT, Kubota, Y, Nedivi, E. 2012. Neuron 74, 361-73.
    doi: 10.1016/j.neuron.2012.02.030PMID:22542188
  10. CPG15 regulates synapse stability in the developing and adult brain. Fujino, T, Leslie, JH, Eavri, R, Chen, JL, Lin, WC, Flanders, GH, Borok, E, Horvath, TL, Nedivi, E. 2011. Genes Dev. 25, 2674-85.
    doi: 10.1101/gad.176172.111PMID:22190461
More Publications
Photo credit: Joshua Sarinana