Sinisa Hrvatin

Sinisa Hrvatin

Assistant Professor of Biology

Sinisa Hrvatin studies states of stasis, such as mammalian torpor and hibernation, as a means to harness the potential of these biological adaptations to advance medicine.

Education

  • PhD, 2013, Harvard University
  • A.B., 2007, Biochemical Sciences, Harvard University

Research Summary

To survive extreme environments, many animals have evolved the ability to profoundly decrease metabolic rate and body temperature and enter states of dormancy, such as torpor and hibernation. Our laboratory studies the mysteries of how animals and their cells initiate, regulate, and survive these adaptations. Specifically, we focus on investigating: 1) how the brain regulates torpor and hibernation, 2) how cells adapt to these states, and 3) whether inducing these states can slow down tissue damage, disease progression, and even aging. Our long-term goal is to explore potential applications of inducing similar states of “suspended animation” in humans.

Sinisa Hrvatin will begin his appointment in January 2022.

Awards

  • Warren Alpert Distinguished Scholar, Warren Albert Foundation, 2019

Key Publications

  1. Neurons that regulate mouse torpor. Hrvatin, S, Sun, S, Wilcox, OF, Yao, H, Lavin-Peter, AJ, Cicconet, M, Assad, EG, Palmer, ME, Aronson, S, Banks, AS et al.. 2020. Nature 583, 115-121.
    doi: 10.1038/s41586-020-2387-5PMID:32528180
  2. A scalable platform for the development of cell-type-specific viral drivers. Hrvatin, S, Tzeng, CP, Nagy, MA, Stroud, H, Koutsioumpa, C, Wilcox, OF, Assad, EG, Green, J, Harvey, CD, Griffith, EC et al.. 2019. Elife 8, .
    doi: 10.7554/eLife.48089PMID:31545165
  3. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Hrvatin, S, Hochbaum, DR, Nagy, MA, Cicconet, M, Robertson, K, Cheadle, L, Zilionis, R, Ratner, A, Borges-Monroy, R, Klein, AM et al.. 2018. Nat Neurosci 21, 120-129.
    doi: 10.1038/s41593-017-0029-5PMID:29230054

Recent Publications

  1. Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability. Boulting, GL, Durresi, E, Ataman, B, Sherman, MA, Mei, K, Harmin, DA, Carter, AC, Hochbaum, DR, Granger, AJ, Engreitz, JM et al.. 2021. Nat Neurosci 24, 437-448.
    doi: 10.1038/s41593-020-00786-1PMID:33542524
  2. An Activity-Mediated Transition in Transcription in Early Postnatal Neurons. Stroud, H, Yang, MG, Tsitohay, YN, Davis, CP, Sherman, MA, Hrvatin, S, Ling, E, Greenberg, ME. 2020. Neuron 107, 874-890.e8.
    doi: 10.1016/j.neuron.2020.06.008PMID:32589877
  3. Neurons that regulate mouse torpor. Hrvatin, S, Sun, S, Wilcox, OF, Yao, H, Lavin-Peter, AJ, Cicconet, M, Assad, EG, Palmer, ME, Aronson, S, Banks, AS et al.. 2020. Nature 583, 115-121.
    doi: 10.1038/s41586-020-2387-5PMID:32528180
  4. A scalable platform for the development of cell-type-specific viral drivers. Hrvatin, S, Tzeng, CP, Nagy, MA, Stroud, H, Koutsioumpa, C, Wilcox, OF, Assad, EG, Green, J, Harvey, CD, Griffith, EC et al.. 2019. Elife 8, .
    doi: 10.7554/eLife.48089PMID:31545165
  5. ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation. Sharma, N, Pollina, EA, Nagy, MA, Yap, EL, DiBiase, FA, Hrvatin, S, Hu, L, Lin, C, Greenberg, ME. 2019. Neuron 102, 390-406.e9.
    doi: 10.1016/j.neuron.2019.02.007PMID:30846309
  6. Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing. Renthal, W, Boxer, LD, Hrvatin, S, Li, E, Silberfeld, A, Nagy, MA, Griffith, EC, Vierbuchen, T, Greenberg, ME. 2018. Nat Neurosci 21, 1670-1679.
    doi: 10.1038/s41593-018-0270-6PMID:30455458
  7. Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Cheadle, L, Tzeng, CP, Kalish, BT, Harmin, DA, Rivera, S, Ling, E, Nagy, MA, Hrvatin, S, Hu, L, Stroud, H et al.. 2018. Neuron 99, 525-539.e10.
    doi: 10.1016/j.neuron.2018.06.036PMID:30033152
  8. Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Hrvatin, S, Hochbaum, DR, Nagy, MA, Cicconet, M, Robertson, K, Cheadle, L, Zilionis, R, Ratner, A, Borges-Monroy, R, Klein, AM et al.. 2018. Nat Neurosci 21, 1017.
    doi: 10.1038/s41593-018-0112-6PMID:29752482
  9. Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement. Kalish, BT, Cheadle, L, Hrvatin, S, Nagy, MA, Rivera, S, Crow, M, Gillis, J, Kirchner, R, Greenberg, ME. 2018. Proc Natl Acad Sci U S A 115, E1051-E1060.
    doi: 10.1073/pnas.1717871115PMID:29343640
  10. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Hrvatin, S, Hochbaum, DR, Nagy, MA, Cicconet, M, Robertson, K, Cheadle, L, Zilionis, R, Ratner, A, Borges-Monroy, R, Klein, AM et al.. 2018. Nat Neurosci 21, 120-129.
    doi: 10.1038/s41593-017-0029-5PMID:29230054
More Publications
Photo credit: Aurora Lavin-Peter