Matthew A. Wilson

Matthew A. Wilson

Sherman Fairchild Professor of Neuroscience and Picower Scholar; Associate Department Head for Education, Brain & Cognitive Sciences

Matthew Wilson studies rodent learning and memory by recording and manipulating the activity of neurons during behavior and sleep.

617-253-2046

Phone

46-5233

Office

James deMelo

Assistant

617-452-4107

Assistant Phone

Education

PhD 1991, California Institute of Technology

Research Summary

Our laboratory studies the neural processes within the hippocampus and neocortex that enable memories to form and persist over time. We use a technique that allows us to simultaneously record the activity of hundreds of individual neurons across multiple brain regions in freely behaving animals. When combined with genetic, pharmacological and behavioral manipulations, these recordings allow us to gain a mechanistic understanding of how animals learn and remember.

Awards

  • American Academy of Arts and Sciences, Fellow, 2012

Recent Publications

  1. Characteristics of CA1 place fields in a complex maze with multiple choice points. Tanila, H, Ku, S, Kloosterman, F, Wilson, MA. 2018. Hippocampus 28, 81-96.
    doi: 10.1002/hipo.22810PMID: 29072798
  2. Oscillations, neural computations and learning during wake and sleep. Penagos, H, Varela, C, Wilson, MA. 2017. Curr. Opin. Neurobiol. 44, 193-201.
    doi: 10.1016/j.conb.2017.05.009PMID: 28570953
  3. Deciphering Neural Codes of Memory during Sleep. Chen, Z, Wilson, MA. 2017. Trends Neurosci. 40, 260-275.
    doi: 10.1016/j.tins.2017.03.005PMID: 28390699
  4. Uncovering representations of sleep-associated hippocampal ensemble spike activity. Chen, Z, Grosmark, AD, Penagos, H, Wilson, MA. 2016. Sci Rep 6, 32193.
    doi: 10.1038/srep32193PMID: 27573200
  5. Slow-γ Rhythms Coordinate Cingulate Cortical Responses to Hippocampal Sharp-Wave Ripples during Wakefulness. Remondes, M, Wilson, MA. 2015. Cell Rep 13, 1327-1335.
    doi: 10.1016/j.celrep.2015.10.005PMID: 26549454
  6. VTA neurons coordinate with the hippocampal reactivation of spatial experience. Gomperts, SN, Kloosterman, F, Wilson, MA. 2015. Elife 4, .
    doi: 10.7554/eLife.05360PMID: 26465113
  7. State-dependent architecture of thalamic reticular subnetworks. Halassa, MM, Chen, Z, Wimmer, RD, Brunetti, PM, Zhao, S, Zikopoulos, B, Wang, F, Brown, EN, Wilson, MA. 2014. Cell 158, 808-821.
    doi: 10.1016/j.cell.2014.06.025PMID: 25126786
  8. Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus. Siegle, JH, Wilson, MA. 2014. Elife 3, e03061.
    PMID: 25073927
  9. Cingulate-hippocampus coherence and trajectory coding in a sequential choice task. Remondes, M, Wilson, MA. 2013. Neuron 80, 1277-89.
    doi: 10.1016/j.neuron.2013.08.037PMID: 24239123
  10. Bayesian decoding using unsorted spikes in the rat hippocampus. Kloosterman, F, Layton, SP, Chen, Z, Wilson, MA. 2014. J. Neurophysiol. 111, 217-27.
    doi: 10.1152/jn.01046.2012PMID: 24089403
More Publications
Photo Credit: Patrick Gillooly