How signaling proteins get to the mitochondrial surface

Whitehead Institute Member Jonathan Weissman and colleagues used large-scale systematic genetic screens to identify the molecules and pathways that populate the mitochondrial surface with important and diverse signaling proteins. They deciphered the logic by which the cell ensures the proper delivery of these proteins. These findings may have important implications for understanding the impact on health and disease when these processes go awry.

Greta Friar | Whitehead Institute
February 26, 2024
Protein production glitches in Huntington’s disease revealed

Research from the Jain Lab finds that, in Huntington's disease, repeats of certain nucleotides too many times in a row interferes with splicing.

January 30, 2024
Blood cell family trees trace how production changes with aging

A new method from the Weissman Lab provides a detailed look at the family trees of human blood cells and the characteristics of individual cells, providing insights into hematopoietic stem cells (HSCs).

January 19, 2024
How cells accurately assemble complex machinery

New research from the Cheeseman Lab reveals how cells control the location of the machinery that splits apart chromosomes during cell division.

January 2, 2024
Sex chromosomes responsible for much more than determining sex

Genes expressed from the X and Y chromosomes impact cells throughout the body—not just in the reproductive system—by dialing up or down the expression of thousands of genes found on other chromosomes.

December 13, 2023