Yadira Soto-Feliciano

Yadira Soto-Feliciano

Assistant Professor of Biology

Yadira Soto-Feliciano studies chromatin and epigenetic regulation in normal development and cancer.

Education

  • PhD, 2016, MIT
  • BS, 2008, Chemistry, University of Puerto Rico-Mayagüez 

Research Summary

We study chromatin — the complex of DNA and proteins that make up our chromosomes. We aim to understand how post-translational modifications to these building-blocks, as well as the factors that regulate these events, play essential roles in maintaining the integrity of cells, tissues, and ultimately entire organisms. We implement a combination of functional genomics, biochemical, genetic, and epigenomic approaches to study how chromatin and epigenetic factors decode the chemical language of chromatin, and how these are dysregulated in diseases such as cancer.

Yadira Soto-Feliciano will begin her appointment in early 2022.

Awards

  • NIH MOSAIC K99/R00 Postdoctoral Career Transition Award, 2021
  • Eddie Méndez Scholar Award, Fred Hutchinson Cancer Research Center, 2020
  • Damon Runyon-Sohn Pediatric Cancer Fellowship, Damon Runyon Cancer Research Foundation, 2017

Key Publications

  1. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
    doi: 10.1101/gad.295857.117PMID:28607179
  2. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
    doi: 10.1101/gad.254151.114PMID:25737277

Recent Publications

  1. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Sánchez-Rivera, FJ, Ryan, J, Soto-Feliciano, YM, Clare Beytagh, M, Xuan, L, Feldser, DM, Hemann, MT, Zamudio, J, Dimitrova, N, Letai, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2019740118PMID:34074758
  2. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Sánchez-Rivera, FJ, Schneider, WM, Luna, JM, Soto-Feliciano, YM, Ashbrook, AW, Le Pen, J, Leal, AA, Ricardo-Lax, I, Michailidis, E et al.. 2021. Cell Host Microbe 29, 267-280.e5.
    doi: 10.1016/j.chom.2020.12.009PMID:33357464
  3. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang, T, Sánchez-Rivera, FJ, Soto-Feliciano, YM, Yang, Q, Song, CQ, Bhuatkar, A, Haynes, CM, Hemann, MT, Xue, W. 2021. Hepatology 74, 233-247.
    doi: 10.1002/hep.31685PMID:33336367
  4. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Schneider, WM, Sánchez-Rivera, FJ, Luna, JM, Ashbrook, AW, Soto-Feliciano, YM, Leal, AA, Le Pen, J, Ricardo-Lax, I, Michailidis, E et al.. 2020. bioRxiv , .
    doi: 10.1101/2020.09.11.291716PMID:32935098
  5. Target identification reveals lanosterol synthase as a vulnerability in glioma. Phillips, RE, Yang, Y, Smith, RC, Thompson, BM, Yamasaki, T, Soto-Feliciano, YM, Funato, K, Liang, Y, Garcia-Bermudez, J, Wang, X et al.. 2019. Proc Natl Acad Sci U S A 116, 7957-7962.
    doi: 10.1073/pnas.1820989116PMID:30923116
  6. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
    doi: 10.1101/gad.295857.117PMID:28607179
  7. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
    doi: 10.1101/gad.254151.114PMID:25737277
  8. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
    doi: 10.1016/j.cell.2013.12.041PMID:24485462
More Publications

Multimedia

Photo credit: Courtesy of Yadira Soto-Feliciano