Education
- PhD, 2016, MIT
- BS, 2008, Chemistry, University of Puerto Rico-Mayagüez
Research Summary
We study chromatin — the complex of DNA and proteins that make up our chromosomes. We aim to understand how post-translational modifications to these building-blocks, as well as the factors that regulate these events, play essential roles in maintaining the integrity of cells, tissues, and ultimately entire organisms. We implement a combination of functional genomics, biochemical, genetic, and epigenomic approaches to study how chromatin and epigenetic factors decode the chemical language of chromatin, and how these are dysregulated in diseases such as cancer.Awards
- AACR Gertrude B. Elion Cancer Research Award, 2023
- V Foundation Award, 2022
- NIH MOSAIC K99/R00 Postdoctoral Career Transition Award, 2021
- Eddie Méndez Scholar Award, Fred Hutchinson Cancer Research Center, 2020
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Damon Runyon-Sohn Pediatric Cancer Fellowship, Damon Runyon Cancer Research Foundation, 2017
Key Publications
- A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano, YM, Sánchez-Rivera, FJ, Perner, F, Barrows, DW, Kastenhuber, ER, Ho, YJ, Carroll, T, Xiong, Y, Anand, D, Soshnev, AA et al.. 2023. Cancer Discov 13, 146-169.
doi: 10.1158/2159-8290.CD-22-0416PMID:36264143 - PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
doi: 10.1101/gad.295857.117PMID:28607179 - A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
doi: 10.1101/gad.254151.114PMID:25737277
Recent Publications
- Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors. Karagiannis, D, Wu, W, Li, A, Hayashi, M, Chen, X, Yip, M, Mangipudy, V, Xu, X, Sánchez-Rivera, FJ, Soto-Feliciano, YM et al.. 2024. Cell Rep 43, 113629.
doi: 10.1016/j.celrep.2023.113629PMID:38165806 - Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma. Chen, X, Li, Y, Zhu, F, Xu, X, Estrella, B, Pazos, MA 2nd, McGuire, JT, Karagiannis, D, Sahu, V, Mustafokulov, M et al.. 2023. Nat Commun 14, 4259.
doi: 10.1038/s41467-023-39990-5PMID:37460547 - MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. Zhu, C, Soto-Feliciano, YM, Morris, JP, Huang, CH, Koche, RP, Ho, YJ, Banito, A, Chen, CW, Shroff, A, Tian, S et al.. 2023. Elife 12, .
doi: 10.7554/eLife.80854PMID:37261974 - Metabolic Reprogramming by Histone Deacetylase Inhibition Selectively Targets NRF2-activated tumors. Karagiannis, D, Wu, W, Li, A, Hayashi, M, Chen, X, Yip, M, Mangipudy, V, Xu, X, Sánchez-Rivera, FJ, Soto-Feliciano, YM et al.. 2023. bioRxiv , .
doi: 10.1101/2023.04.24.538118PMID:37162970 - A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano, YM, Sánchez-Rivera, FJ, Perner, F, Barrows, DW, Kastenhuber, ER, Ho, YJ, Carroll, T, Xiong, Y, Anand, D, Soshnev, AA et al.. 2023. Cancer Discov 13, 146-169.
doi: 10.1158/2159-8290.CD-22-0416PMID:36264143 - Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Sánchez-Rivera, FJ, Ryan, J, Soto-Feliciano, YM, Clare Beytagh, M, Xuan, L, Feldser, DM, Hemann, MT, Zamudio, J, Dimitrova, N, Letai, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
doi: 10.1073/pnas.2019740118PMID:34074758 - Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Sánchez-Rivera, FJ, Schneider, WM, Luna, JM, Soto-Feliciano, YM, Ashbrook, AW, Le Pen, J, Leal, AA, Ricardo-Lax, I, Michailidis, E et al.. 2021. Cell Host Microbe 29, 267-280.e5.
doi: 10.1016/j.chom.2020.12.009PMID:33357464 - Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang, T, Sánchez-Rivera, FJ, Soto-Feliciano, YM, Yang, Q, Song, CQ, Bhuatkar, A, Haynes, CM, Hemann, MT, Xue, W. 2021. Hepatology 74, 233-247.
doi: 10.1002/hep.31685PMID:33336367 - Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Schneider, WM, Sánchez-Rivera, FJ, Luna, JM, Ashbrook, AW, Soto-Feliciano, YM, Leal, AA, Le Pen, J, Ricardo-Lax, I, Michailidis, E et al.. 2020. bioRxiv , .
doi: 10.1101/2020.09.11.291716PMID:32935098 - Target identification reveals lanosterol synthase as a vulnerability in glioma. Phillips, RE, Yang, Y, Smith, RC, Thompson, BM, Yamasaki, T, Soto-Feliciano, YM, Funato, K, Liang, Y, Garcia-Bermudez, J, Wang, X et al.. 2019. Proc Natl Acad Sci U S A 116, 7957-7962.
doi: 10.1073/pnas.1820989116PMID:30923116 - A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Soto-Feliciano YM*, Sánchez-Rivera FJ*, Perner F*, Barrows DW, Kastenhuber E, Ho YJ, Carroll T, Xiong Y, Soshnev A, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA#, Lowe SW#, Allis CD#. *Co-first author, #Co-corresponding author. 2021. bioRxiv.
doi: https://doi.org/10.1101/2021.10.22.465184.
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