Yadira Soto-Feliciano

Yadira Soto-Feliciano

Assistant Professor of Biology; Intramural Faculty, Koch Institute

Yadira Soto-Feliciano studies chromatin and epigenetic regulation in normal development and cancer.

617-253-3026

Phone

76-561C

Office

Paul Thompson

Assistant

617-258-0480

Assistant Phone

Education

  • PhD, 2016, MIT
  • BS, 2008, Chemistry, University of Puerto Rico-Mayagüez 

Research Summary

We study chromatin — the complex of DNA and proteins that make up our chromosomes. We aim to understand how post-translational modifications to these building-blocks, as well as the factors that regulate these events, play essential roles in maintaining the integrity of cells, tissues, and ultimately entire organisms. We implement a combination of functional genomics, biochemical, genetic, and epigenomic approaches to study how chromatin and epigenetic factors decode the chemical language of chromatin, and how these are dysregulated in diseases such as cancer.

Awards

  • NIH MOSAIC K99/R00 Postdoctoral Career Transition Award, 2021
  • Eddie Méndez Scholar Award, Fred Hutchinson Cancer Research Center, 2020
  • Damon Runyon-Sohn Pediatric Cancer Fellowship, Damon Runyon Cancer Research Foundation, 2017

Key Publications

  1. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
    doi: 10.1101/gad.295857.117PMID:28607179
  2. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
    doi: 10.1101/gad.254151.114PMID:25737277
  3. A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Soto-Feliciano YM*, Sánchez-Rivera FJ*, Perner F*, Barrows DW, Kastenhuber E, Ho YJ, Carroll T, Xiong Y, Soshnev A, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA#, Lowe SW#, Allis CD#. *Co-first author, #Co-corresponding author. 2021. bioRxiv.
    doi: https://doi.org/10.1101/2021.10.22.465184.

Recent Publications

  1. Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Sánchez-Rivera, FJ, Ryan, J, Soto-Feliciano, YM, Clare Beytagh, M, Xuan, L, Feldser, DM, Hemann, MT, Zamudio, J, Dimitrova, N, Letai, A et al.. 2021. Proc Natl Acad Sci U S A 118, .
    doi: 10.1073/pnas.2019740118PMID:34074758
  2. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Sánchez-Rivera, FJ, Schneider, WM, Luna, JM, Soto-Feliciano, YM, Ashbrook, AW, Le Pen, J, Leal, AA, Ricardo-Lax, I, Michailidis, E et al.. 2021. Cell Host Microbe 29, 267-280.e5.
    doi: 10.1016/j.chom.2020.12.009PMID:33357464
  3. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang, T, Sánchez-Rivera, FJ, Soto-Feliciano, YM, Yang, Q, Song, CQ, Bhuatkar, A, Haynes, CM, Hemann, MT, Xue, W. 2021. Hepatology 74, 233-247.
    doi: 10.1002/hep.31685PMID:33336367
  4. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Hoffmann, HH, Schneider, WM, Sánchez-Rivera, FJ, Luna, JM, Ashbrook, AW, Soto-Feliciano, YM, Leal, AA, Le Pen, J, Ricardo-Lax, I, Michailidis, E et al.. 2020. bioRxiv , .
    doi: 10.1101/2020.09.11.291716PMID:32935098
  5. Target identification reveals lanosterol synthase as a vulnerability in glioma. Phillips, RE, Yang, Y, Smith, RC, Thompson, BM, Yamasaki, T, Soto-Feliciano, YM, Funato, K, Liang, Y, Garcia-Bermudez, J, Wang, X et al.. 2019. Proc Natl Acad Sci U S A 116, 7957-7962.
    doi: 10.1073/pnas.1820989116PMID:30923116
  6. PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Soto-Feliciano, YM, Bartlebaugh, JME, Liu, Y, Sánchez-Rivera, FJ, Bhutkar, A, Weintraub, AS, Buenrostro, JD, Cheng, CS, Regev, A, Jacks, TE et al.. 2017. Genes Dev 31, 973-989.
    doi: 10.1101/gad.295857.117PMID:28607179
  7. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, JR, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA et al.. 2015. Genes Dev 29, 483-8.
    doi: 10.1101/gad.254151.114PMID:25737277
  8. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
    doi: 10.1016/j.cell.2013.12.041PMID:24485462
  9. A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition. Soto-Feliciano YM*, Sánchez-Rivera FJ*, Perner F*, Barrows DW, Kastenhuber E, Ho YJ, Carroll T, Xiong Y, Soshnev A, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA#, Lowe SW#, Allis CD#. *Co-first author, #Co-corresponding author. 2021. bioRxiv.
    doi: https://doi.org/10.1101/2021.10.22.465184.
More Publications

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Photo credit: Courtesy of Yadira Soto-Feliciano