A professor and mentor at MIT for over 20 years, Amon performed pioneering research on aneuploidy — what happens when a cell has the wrong number of chromosomes. She made profound contributions to our understanding of the fundamental biology of the cell, deciphering the regulatory networks that govern cell division and proliferation in yeast, mice, and mammalian organoids, and shedding light on the causes of chromosome mis-segregation and its consequences for human diseases.