Angelika Amon

Angelika Amon

Kathleen and Curtis Marble Professor of Cancer Research; Investigator, Howard Hughes Medical Institute

Angelika Amon examines cell growth and division, and how errors in this process contribute to cancer and aging.

617-258-8964

Phone

76-561

Office

Erica Burds

Assistant

617-258-6559

Assistant Phone

Education

  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

We study cell growth and division. Specifically, we investigate how macromolecule biosynthesis is coordinated with cell division, and how chromosome segregation is is regulated by intracellular and extracellular cues. We also analyze the consequences of chromosome mis-segregation on cell and organismal physiology, and how these repercussions can lead to cancer and aging.

Awards

  • Breakthrough Prize in Life Sciences, 2019
  • American Academy of Arts and Sciences, Member 2017
  • Elected Foreign Associate to EMBO, 2015
  • Elected Foreign Associate to the Austrian Academy of Sciences, 2015
  • Genetics Society of America Medal, 2014
  • Ernst Jung Prize for Medicine, 2013
  • National Academy of Sciences, Member, 2010
  • National Academy of Sciences Award in Molecular Biology, 2008
  • Paul Marks Prize, 2007
  • ASBMB Amgen Award, 2007
  • Alan T. Waterman Award, 2003
  • Eli Lilly and Company Research Award, 2003
  • Howard Hughes Medical Institute, HHMI Investigator, 2000

Key Publications

  1. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Santaguida, S, Richardson, A, Iyer, DR, M'Saad, O, Zasadil, L, Knouse, KA, Wong, YL, Rhind, N, Desai, A, Amon, A et al.. 2017. Dev. Cell 41, 638-651.e5.
    doi: 10.1016/j.devcel.2017.05.022PMID:28633018
  2. Aneuploidy Causes Non-genetic Individuality. Beach, RR, Ricci-Tam, C, Brennan, CM, Moomau, CA, Hsu, PH, Hua, B, Silberman, RE, Springer, M, Amon, A. 2017. Cell 169, 229-242.e21.
    doi: 10.1016/j.cell.2017.03.021PMID:28388408
  3. Single-chromosome Gains Commonly Function as Tumor Suppressors. Sheltzer, JM, Ko, JH, Replogle, JM, Habibe Burgos, NC, Chung, ES, Meehl, CM, Sayles, NM, Passerini, V, Storchova, Z, Amon, A et al.. 2017. Cancer Cell 31, 240-255.
    doi: 10.1016/j.ccell.2016.12.004PMID:28089890
  4. Spatial signals link exit from mitosis to spindle position. Falk, JE, Tsuchiya, D, Verdaasdonk, J, Lacefield, S, Bloom, K, Amon, A. 2016. Elife 5, .
    doi: 10.7554/eLife.14036PMID:27166637
  5. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz, LE, Kabachinski, G, Walker, MR, Carlile, TM, Gilbert, WV, Schwartz, TU, Amon, A. 2015. Cell 163, 406-18.
    doi: 10.1016/j.cell.2015.08.060PMID:26411291

Recent Publications

  1. Context is everything: aneuploidy in cancer. Ben-David, U, Amon, A. 2019. Nat. Rev. Genet. , .
    doi: 10.1038/s41576-019-0171-xPMID:31548659
  2. Evaluation of Chen et al.: Overexpression of Protein Complexes and Aneuploidy. Amon, A. 2019. Cell Syst 9, 107-108.
    doi: 10.1016/j.cels.2019.08.004PMID:31465727
  3. Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells. Brennan, CM, Vaites, LP, Wells, JN, Santaguida, S, Paulo, JA, Storchova, Z, Harper, JW, Marsh, JA, Amon, A. 2019. Genes Dev. 33, 1031-1047.
    doi: 10.1101/gad.327494.119PMID:31196865
  4. Why haploinsufficiency persists. Morrill, SA, Amon, A. 2019. Proc. Natl. Acad. Sci. U.S.A. 116, 11866-11871.
    doi: 10.1073/pnas.1900437116PMID:31142641
  5. Aneuploidy drives lethal progression in prostate cancer. Stopsack, KH, Whittaker, CA, Gerke, TA, Loda, M, Kantoff, PW, Mucci, LA, Amon, A. 2019. Proc. Natl. Acad. Sci. U.S.A. 116, 11390-11395.
    doi: 10.1073/pnas.1902645116PMID:31085648
  6. Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence. Neurohr, GE, Terry, RL, Lengefeld, J, Bonney, M, Brittingham, GP, Moretto, F, Miettinen, TP, Vaites, LP, Soares, LM, Paulo, JA et al.. 2019. Cell 176, 1083-1097.e18.
    doi: 10.1016/j.cell.2019.01.018PMID:30739799
  7. The Mitotic Exit Network integrates temporal and spatial signals by distributing regulation across multiple components. Campbell, IW, Zhou, X, Amon, A. 2019. Elife 8, .
    doi: 10.7554/eLife.41139PMID:30672733
  8. Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Knouse, KA, Lopez, KE, Bachofner, M, Amon, A. 2018. Cell 175, 200-211.e13.
    doi: 10.1016/j.cell.2018.07.042PMID:30146160
  9. Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells. Neurohr, GE, Terry, RL, Sandikci, A, Zou, K, Li, H, Amon, A. 2018. Genes Dev. 32, 1075-1084.
    doi: 10.1101/gad.312140.118PMID:30042134
  10. MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress. Weidberg, H, Amon, A. 2018. Science 360, .
    doi: 10.1126/science.aan4146PMID:29650645
More Publications

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Photo credit: Samara Vise