Angelika Amon

Angelika Amon

(1967 - 2020) Kathleen and Curtis Marble Professor of Cancer Research; Investigator, Howard Hughes Medical Institute

Angelika Amon's lab examines cell growth and division, and how errors in this process contribute to cancer and aging.



Erica Burds



Assistant Phone

Angelika Amon passed away on October 29, 2020. This page will continue to be maintained as her lab members complete their work.


  • PhD, 1993, University of Vienna
  • BS, 1989, Biology, University of Vienna

Research Summary

The Amon lab studies cell growth and division. They investigate how macromolecule biosynthesis is coordinated with cell division, and how chromosome segregation is is regulated by intracellular and extracellular cues. They also analyze the consequences of chromosome mis-segregation on cell and organismal physiology, and how these repercussions can lead to cancer and aging.


  • Nakasone Award, Human Frontier Science Program, 2020
  • Breakthrough Prize in Life Sciences, 2019
  • Vilcek Foundation Prize in Biomedical Science, 2019
  • American Academy of Arts and Sciences, Member, 2017
  • Elected Foreign Associate to EMBO, 2015
  • Elected Foreign Associate to the Austrian Academy of Sciences, 2015
  • Genetics Society of America Medal, 2014
  • Ernst Jung Prize for Medicine, 2013
  • National Academy of Sciences, Member, 2010
  • National Academy of Sciences Award in Molecular Biology, 2008
  • Paul Marks Prize, 2007
  • ASBMB Amgen Award, 2007
  • Alan T. Waterman Award, 2003
  • Eli Lilly and Company Research Award, 2003
  • Howard Hughes Medical Institute, HHMI Investigator, 2000

Key Publications

  1. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Santaguida, S, Richardson, A, Iyer, DR, M'Saad, O, Zasadil, L, Knouse, KA, Wong, YL, Rhind, N, Desai, A, Amon, A et al.. 2017. Dev Cell 41, 638-651.e5.
    doi: 10.1016/j.devcel.2017.05.022PMID:28633018
  2. Aneuploidy Causes Non-genetic Individuality. Beach, RR, Ricci-Tam, C, Brennan, CM, Moomau, CA, Hsu, PH, Hua, B, Silberman, RE, Springer, M, Amon, A. 2017. Cell 169, 229-242.e21.
    doi: 10.1016/j.cell.2017.03.021PMID:28388408
  3. Single-chromosome Gains Commonly Function as Tumor Suppressors. Sheltzer, JM, Ko, JH, Replogle, JM, Habibe Burgos, NC, Chung, ES, Meehl, CM, Sayles, NM, Passerini, V, Storchova, Z, Amon, A et al.. 2017. Cancer Cell 31, 240-255.
    doi: 10.1016/j.ccell.2016.12.004PMID:28089890
  4. Spatial signals link exit from mitosis to spindle position. Falk, JE, Tsuchiya, D, Verdaasdonk, J, Lacefield, S, Bloom, K, Amon, A. 2016. Elife 5, .
    doi: 10.7554/eLife.14036PMID:27166637
  5. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz, LE, Kabachinski, G, Walker, MR, Carlile, TM, Gilbert, WV, Schwartz, TU, Amon, A. 2015. Cell 163, 406-18.
    doi: 10.1016/j.cell.2015.08.060PMID:26411291

Recent Publications

  1. Cell size is a determinant of stem cell potential during aging. Lengefeld, J, Cheng, CW, Maretich, P, Blair, M, Hagen, H, McReynolds, MR, Sullivan, E, Majors, K, Roberts, C, Kang, JH et al.. 2021. Sci Adv 7, eabk0271.
    doi: 10.1126/sciadv.abk0271PMID:34767451
  2. Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA. Corbi, D, Amon, A. 2021. PLoS Genet 17, e1009808.
    doi: 10.1371/journal.pgen.1009808PMID:34665800
  3. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Trakala, M, Aggarwal, M, Sniffen, C, Zasadil, L, Carroll, A, Ma, D, Su, XA, Wangsa, D, Meyer, A, Sieben, CJ et al.. 2021. Genes Dev 35, 1079-1092.
    doi: 10.1101/gad.348341.121PMID:34266888
  4. Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response. Kane, AJ, Brennan, CM, Xu, AE, Solís, EJ, Terhorst, A, Denic, V, Amon, A. 2021. Mol Biol Cell 32, 1557-1564.
    doi: 10.1091/mbc.E21-03-0104PMID:34191542
  5. RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress. Su, XA, Ma, D, Parsons, JV, Replogle, JM, Amatruda, JF, Whittaker, CA, Stegmaier, K, Amon, A. 2021. Genes Dev 35, 556-572.
    doi: 10.1101/gad.345454.120PMID:33766983
  6. Cross-compartment signal propagation in the mitotic exit network. Zhou, X, Li, W, Liu, Y, Amon, A. 2021. Elife 10, .
    doi: 10.7554/eLife.63645PMID:33481703
  7. Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division. Replogle, JM, Zhou, W, Amaro, AE, McFarland, JM, Villalobos-Ortiz, M, Ryan, J, Letai, A, Yilmaz, O, Sheltzer, J, Lippard, SJ et al.. 2020. Proc Natl Acad Sci U S A 117, 30566-30576.
    doi: 10.1073/pnas.2009506117PMID:33203674
  8. The environmental stress response causes ribosome loss in aneuploid yeast cells. Terhorst, A, Sandikci, A, Keller, A, Whittaker, CA, Dunham, MJ, Amon, A. 2020. Proc Natl Acad Sci U S A 117, 17031-17040.
    doi: 10.1073/pnas.2005648117PMID:32632008
  9. Spindle pole bodies function as signal amplifiers in the Mitotic Exit Network. Campbell, IW, Zhou, X, Amon, A. 2020. Mol Biol Cell 31, 906-916.
    doi: 10.1091/mbc.E19-10-0584PMID:32074005
  10. Relevance and Regulation of Cell Density. Neurohr, GE, Amon, A. 2020. Trends Cell Biol 30, 213-225.
    doi: 10.1016/j.tcb.2019.12.006PMID:31980346
More Publications










Photo credit: Samara Vise