The Cryo-EM Center is located in MIT.nano, a new shared research building on campus. The facility is commissioning Titan Krios and Talos Arctica cryo-TEMs for high-throughput imaging of purified macromolecules and tomography of cellular specimens. It also includes an Aquilos cryo-FIB/SEM and specimen preparation instrumentation including a Vitrobot and a Chameleon (aka Spot-It-On).