EducationPhD 1988, University of California, San Francisco
Research SummaryDr. Jacks’ research has focused on developing new methods for the construction and characterization of genetically engineered mouse models or GEMMs of human cancer, and recently has moved into the burgeoning area of tumor immunology to understand the interactions between the immune system and cancer. His group has produced GEMMs with constitutive and conditional mutations in several tumor suppressor genes, oncogenes, and genes involved in oxidative stress, DNA repair and epigenetic control of gene expression. These GEMMS have been used to examine the mechanism of tumor initiation and progression, to uncover the molecular, genetic and biochemical relationship to the human diseases, as tools to study response and resistance to chemotherapy, and to explore methods in molecular imaging and early detection of cancer.
- Massachusetts Institute of Technology, James R Killian Jr Faculty Achievement Award, 2015
- Sergio Lombroso Award in Cancer Research, 2015
- American Academy of Arts and Sciences, Fellow, 2012
- National Academy of Sciences, Member, 2009
- Institute of Medicine of the National Academies, Member, 2009
- Paul Marks Prize for Cancer Research, 2005
- Howard Hughes Medical Institute, HHMI Investigator, 1994
- Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Joshi, NS, Akama-Garren, EH, Lu, Y, Lee, DY, Chang, GP, Li, A, DuPage, M, Tammela, T, Kerper, NR, Farago, AF et al.. 2015. Immunity 43, 579-90.
- CRISPR-mediated direct mutation of cancer genes in the mouse liver. Xue, W, Chen, S, Yin, H, Tammela, T, Papagiannakopoulos, T, Joshi, NS, Cai, W, Yang, G, Bronson, R, Crowley, DG et al.. 2014. Nature 514, 380-4.
- Expression of tumour-specific antigens underlies cancer immunoediting. DuPage, M, Mazumdar, C, Schmidt, LM, Cheung, AF, Jacks, T. 2012. Nature 482, 405-9.
- The differential effects of mutant p53 alleles on advanced murine lung cancer. Jackson, EL, Olive, KP, Tuveson, DA, Bronson, R, Crowley, D, Brown, M, Jacks, T. 2005. Cancer Res. 65, 10280-8.
- Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Johnson, L, Mercer, K, Greenbaum, D, Bronson, RT, Crowley, D, Tuveson, DA, Jacks, T. 2001. Nature 410, 1111-6.