Thomas U. Schwartz

Thomas U. Schwartz

Boris Magasanik Professor of Biology

Thomas U. Schwartz investigates communication across biological membranes, using structural, biochemical, and genetic tools.

617-452-3851

Phone

68-480

Office

tus@mit.edu

Email

Sarah Wylie

Assistant

617-253-9395

Assistant Phone

Education

PhD 2000, Free University of Berlin

Research Summary

Our primary goal is to understand how signals and molecules are transmitted between the nucleus and cytoplasm across the nuclear envelope. We work to decipher the mechanism and structure of the machinery that executes these cellular processes.

Key Publications

  1. Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Demircioglu, FE, Sosa, BA, Ingram, J, Ploegh, HL, Schwartz, TU. 2016. Elife 5, .
    doi: 10.7554/eLife.17983PMID:27490483
  2. The Nuclear Pore Complex as a Flexible and Dynamic Gate. Knockenhauer, KE, Schwartz, TU. 2016. Cell 164, 1162-1171.
    doi: 10.1016/j.cell.2016.01.034PMID:26967283
  3. Atomic structure of the Y complex of the nuclear pore. Kelley, K, Knockenhauer, KE, Kabachinski, G, Schwartz, TU. 2015. Nat. Struct. Mol. Biol. 22, 425-431.
    doi: 10.1038/nsmb.2998PMID:25822992
  4. LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Sosa, BA, Rothballer, A, Kutay, U, Schwartz, TU. 2012. Cell 149, 1035-47.
    doi: 10.1016/j.cell.2012.03.046PMID:22632968
  5. Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Brohawn, SG, Leksa, NC, Spear, ED, Rajashankar, KR, Schwartz, TU. 2008. Science 322, 1369-73.
    doi: 10.1126/science.1165886PMID:18974315

Recent Publications

  1. Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex. Onischenko, E, Tang, JH, Andersen, KR, Knockenhauer, KE, Vallotton, P, Derrer, CP, Kralt, A, Mugler, CF, Chan, LY, Schwartz, TU et al.. 2017. Cell 171, 904-917.e19.
    doi: 10.1016/j.cell.2017.09.033PMID:29033133
  2. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. Hanke, L, Schmidt, FI, Knockenhauer, KE, Morin, B, Whelan, SP, Schwartz, TU, Ploegh, HL. 2017. EMBO Rep. 18, 1027-1037.
    doi: 10.15252/embr.201643764PMID:28396572
  3. The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment. Hanke, L, Knockenhauer, KE, Brewer, RC, van Diest, E, Schmidt, FI, Schwartz, TU, Ploegh, HL. 2016. MBio 7, .
    doi: 10.1128/mBio.01569-16PMID:27965447
  4. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. Lawrence, KS, Tapley, EC, Cruz, VE, Li, Q, Aung, K, Hart, KC, Schwartz, TU, Starr, DA, Engebrecht, J. 2016. J. Cell Biol. 215, 801-821.
    doi: 10.1083/jcb.201604112PMID:27956467
  5. The apo-structure of the leucine sensor Sestrin2 is still elusive. Saxton, RA, Knockenhauer, KE, Schwartz, TU, Sabatini, DM. 2016. Sci Signal 9, ra92.
    doi: 10.1126/scisignal.aah4497PMID:27649739
  6. Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Demircioglu, FE, Sosa, BA, Ingram, J, Ploegh, HL, Schwartz, TU. 2016. Elife 5, .
    doi: 10.7554/eLife.17983PMID:27490483
  7. Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex. Apelt, L, Knockenhauer, KE, Leksa, NC, Benlasfer, N, Schwartz, TU, Stelzl, U. 2016. Mol. Cell Proteomics 15, 2594-606.
    doi: 10.1074/mcp.M115.054627PMID:27194810
  8. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann, MC, Cruz, VE, Guo, X, Engert, C, Schwartz, TU, Ploegh, HL. 2016. PLoS Genet. 12, e1006023.
    doi: 10.1371/journal.pgen.1006023PMID:27138431
  9. The Structure Inventory of the Nuclear Pore Complex. Schwartz, TU. 2016. J. Mol. Biol. 428, 1986-2000.
    doi: 10.1016/j.jmb.2016.03.015PMID:27016207
  10. The Nuclear Pore Complex as a Flexible and Dynamic Gate. Knockenhauer, KE, Schwartz, TU. 2016. Cell 164, 1162-1171.
    doi: 10.1016/j.cell.2016.01.034PMID:26967283
More Publications