Thomas U. Schwartz

Thomas U. Schwartz

Boris Magasanik Professor of Biology

Thomas U. Schwartz investigates communication across biological membranes, using structural, biochemical, and genetic tools.

617-452-3851

Phone

68-480

Office

tus@mit.edu

Email

Building 68 - Koch Biology Building

Location

Lab Website
Jessica Klees

Assistant

Education

  • PhD, 2000, Free University of Berlin
  • MS, 1996, Biochemistry, Free University of Berlin
  • BS, 1993, Biochemistry, Free University of Berlin

Research Summary

Our primary goal is to understand how signals and molecules are transmitted between the nucleus and cytoplasm across the nuclear envelope. We work to decipher the mechanism and structure of the machinery that executes these cellular processes.

Key Publications

Recent Publications

  1. HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor. Fu, L, Weiskopf, EN, Akkermans, O, Swanson, NA, Cheng, S, Schwartz, TU, Görlich, D. 2024. Nature 626, 843-851.
    doi: 10.1038/s41586-023-06966-wPMID:38267583
  2. FHODs: Nuclear tethered formins for nuclear mechanotransduction. Antoku, S, Schwartz, TU, Gundersen, GG. 2023. Front Cell Dev Biol 11, 1160219.
    doi: 10.3389/fcell.2023.1160219PMID:37215084
  3. Structure and specificity of an anti-chloramphenicol single domain antibody for detection of amphenicol residues. Swofford, CA, Nordeen, SA, Chen, L, Desai, MM, Chen, J, Springs, SL, Schwartz, TU, Sinskey, AJ. 2022. Protein Sci 31, e4457.
    doi: 10.1002/pro.4457PMID:36153664
  4. Solving the nuclear pore puzzle. Schwartz, TU. 2022. Science 376, 1158-1159.
    doi: 10.1126/science.abq4792PMID:35679398
  5. Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Singh, RK, Soliman, A, Guaitoli, G, Störmer, E, von Zweydorf, F, Dal Maso, T, Oun, A, Van Rillaer, L, Schmidt, SH, Chatterjee, D et al.. 2022. Proc Natl Acad Sci U S A 119, .
    doi: 10.1073/pnas.2112712119PMID:35217606
  6. The cellular environment shapes the nuclear pore complex architecture. Schuller, AP, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, SG, Dip, PV, Lytton-Jean, AKR, Brignole, EJ, Dasso, M et al.. 2021. Nature 598, 667-671.
    doi: 10.1038/s41586-021-03985-3PMID:34646014
  7. Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. Lim, SM, Cruz, VE, Antoku, S, Gundersen, GG, Schwartz, TU. 2021. Structure 29, 540-552.e5.
    doi: 10.1016/j.str.2020.12.013PMID:33472039
  8. A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure. Nordeen, SA, Andersen, KR, Knockenhauer, KE, Ingram, JR, Ploegh, HL, Schwartz, TU. 2020. Nat Commun 11, 6179.
    doi: 10.1038/s41467-020-19884-6PMID:33268786
  9. Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif. Nordeen, SA, Turman, DL, Schwartz, TU. 2020. Nat Commun 11, 6060.
    doi: 10.1038/s41467-020-19885-5PMID:33247142
  10. Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes. Cruz, VE, Esra Demircioglu, F, Schwartz, TU. 2020. J Mol Biol 432, 6028-6041.
    doi: 10.1016/j.jmb.2020.09.019PMID:33058875
More Publications