Education
- PhD, 2012, Washington University in St. Louis
- BS, 2004, Cellular and Molecular Biology and Studio Art, Tulane University
Research Summary
Our lab is interested in the molecular events that enable apicomplexan parasites to remain widespread and deadly infectious agents. We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum. We seek to expand our understanding of eukaryotic diversity and identify specific features that can be targeted to treat parasite infections.Awards
- Odyssey Award, Smith Family Foundation, 2021
Recent Publications
- Discovery of antibiotics that selectively kill metabolically dormant bacteria. Zheng, EJ, Valeri, JA, Andrews, IW, Krishnan, A, Bandyopadhyay, P, Anahtar, MN, Herneisen, A, Schulte, F, Linnehan, B, Wong, F et al.. 2023. Cell Chem Biol , .
doi: 10.1016/j.chembiol.2023.10.026PMID:38029756 - SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle. Herneisen, AL, Peters, ML, Smith, TA, Lourido, S. 2023. bioRxiv , .
doi: 10.1101/2023.10.30.564746PMID:37961644 - Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors. Wang, F, Holmes, MJ, Hong, HJ, Thaprawat, P, Kannan, G, Huynh, MH, Schultz, TL, Licon, MH, Lourido, S, Sullivan, WJ et al.. 2023. bioRxiv , .
doi: 10.1101/2023.11.03.565545PMID:37961607 - Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma. Chan, AW, Broncel, M, Yifrach, E, Haseley, NR, Chakladar, S, Andree, E, Herneisen, AL, Shortt, E, Treeck, M, Lourido, S et al.. 2023. Elife 12, .
doi: 10.7554/eLife.85654PMID:37933960 - A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma. Valleau, D, Sidik, SM, Godoy, LC, Acevedo-Sánchez, Y, Pasaje, CFA, Huynh, MH, Carruthers, VB, Niles, JC, Lourido, S. 2023. EMBO J 42, e113155.
doi: 10.15252/embj.2022113155PMID:37886905 - The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites. Schwarz, D, Lourido, S. 2023. Curr Opin Microbiol 76, 102395.
doi: 10.1016/j.mib.2023.102395PMID:37866202 - CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility. Shortt, E, Hackett, CG, Stadler, RV, Kent, RS, Herneisen, AL, Ward, GE, Lourido, S. 2023. mBio 14, e0135823.
doi: 10.1128/mbio.01358-23PMID:37610220 - Author Correction: A positive feedback loop controls Toxoplasma chronic differentiation. Licon, MH, Giuliano, CJ, Chan, AW, Chakladar, S, Eberhard, JN, Shallberg, LA, Chandrasekaran, S, Waldman, BS, Koshy, AA, Hunter, CA et al.. 2023. Nat Microbiol , .
doi: 10.1038/s41564-023-01467-yPMID:37582867 - A positive feedback loop controls Toxoplasma chronic differentiation. Licon, MH, Giuliano, CJ, Chan, AW, Chakladar, S, Eberhard, JN, Shallberg, LA, Chandrasekaran, S, Waldman, BS, Koshy, AA, Hunter, CA et al.. 2023. Nat Microbiol 8, 889-904.
doi: 10.1038/s41564-023-01358-2PMID:37081202 - Functional profiling of the Toxoplasma genome during acute mouse infection. Giuliano, CJ, Wei, KJ, Harling, FM, Waldman, BS, Farringer, MA, Boydston, EA, Lan, TCT, Thomas, RW, Herneisen, AL, Sanderlin, AG et al.. 2023. bioRxiv , .
doi: 10.1101/2023.03.05.531216PMID:36945434
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