Sebastian Lourido

Sebastian Lourido

Latham Family Career Development Professor; Member, Whitehead Institute

Sebastian Lourido exposes parasite vulnerabilities and harnesses them to treat infectious disease.





Gabrielle McCauley



Assistant Phone


  • PhD, 2012, Washington University in St. Louis
  • BS, 2004, Cellular and Molecular Biology and Studio Art, Tulane University

Research Summary

Our lab is interested in the molecular events that enable apicomplexan parasites to remain widespread and deadly infectious agents. We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum. We seek to expand our understanding of eukaryotic diversity and identify specific features that can be targeted to treat parasite infections.

Recent Publications

  1. Toxoplasma gondii. Lourido, S. 2019. Trends Parasitol. , .
    doi: 10.1016/
  2. Optimizing Systems for Cas9 Expression in Toxoplasma gondii. Markus, BM, Bell, GW, Lorenzi, HA, Lourido, S. 2019. mSphere 4, .
    doi: 10.1128/mSphere.00386-19PMID:31243081
  3. Alveolar proteins stabilize cortical microtubules in Toxoplasma gondii. Harding, CR, Gow, M, Kang, JH, Shortt, E, Manalis, SR, Meissner, M, Lourido, S. 2019. Nat Commun 10, 401.
    doi: 10.1038/s41467-019-08318-7PMID:30674885
  4. Identification of cryptic subunits from an apicomplexan ATP synthase. Huet, D, Rajendran, E, van Dooren, GG, Lourido, S. 2018. Elife 7, .
    doi: 10.7554/eLife.38097PMID:30204085
  5. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum. Arranz-Solís, D, Regidor-Cerrillo, J, Lourido, S, Ortega-Mora, LM, Saeij, JPJ. 2018. Int. J. Parasitol. 48, 597-600.
    doi: 10.1016/j.ijpara.2018.03.002PMID:29625127
  6. Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition. Hara, M, Lourido, S, Petrova, B, Lou, HJ, Von Stetina, JR, Kashevsky, H, Turk, BE, Orr-Weaver, TL. 2018. Elife 7, .
    doi: 10.7554/eLife.33150PMID:29480805
  7. CRISPR-Cas9-based genome-wide screening of Toxoplasma gondii. Sidik, SM, Huet, D, Lourido, S. 2018. Nat Protoc 13, 307-323.
    doi: 10.1038/nprot.2017.131PMID:29323662
  8. O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii. Bandini, G, Haserick, JR, Motari, E, Ouologuem, DT, Lourido, S, Roos, DS, Costello, CE, Robbins, PW, Samuelson, J. 2016. Proc. Natl. Acad. Sci. U.S.A. 113, 11567-11572.
    doi: 10.1073/pnas.1613653113PMID:27663739
  9. A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, SM, Huet, D, Ganesan, SM, Huynh, MH, Wang, T, Nasamu, AS, Thiru, P, Saeij, JPJ, Carruthers, VB, Niles, JC et al.. 2016. Cell 166, 1423-1435.e12.
    doi: 10.1016/j.cell.2016.08.019PMID:27594426
  10. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Chahal, JS, Khan, OF, Cooper, CL, McPartlan, JS, Tsosie, JK, Tilley, LD, Sidik, SM, Lourido, S, Langer, R, Bavari, S et al.. 2016. Proc. Natl. Acad. Sci. U.S.A. 113, E4133-42.
    doi: 10.1073/pnas.1600299113PMID:27382155
More Publications




Photo credit: Gretchen Ertl/Whitehead Institute