Sebastian Lourido

Sebastian Lourido

Latham Family Career Development Professor; Member, Whitehead Institute

Sebastian Lourido exposes parasite vulnerabilities and harnesses them to treat infectious disease.

617-324-4920

Phone

WI-561D

Office

Gabrielle McCauley

Assistant

617-258-5251

Assistant Phone

Education

  • PhD, 2012, Washington University in St. Louis
  • BS, 2004, Cellular and Molecular Biology and Studio Art, Tulane University

Research Summary

Our lab is interested in the molecular events that enable apicomplexan parasites to remain widespread and deadly infectious agents. We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum. We seek to expand our understanding of eukaryotic diversity and identify specific features that can be targeted to treat parasite infections.

Recent Publications

  1. Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages. Wang, Y, Sangaré, LO, Paredes-Santos, TC, Hassan, MA, Krishnamurthy, S, Furuta, AM, Markus, BM, Lourido, S, Saeij, JPJ. 2020. Nat Commun 11, 5258.
    doi: 10.1038/s41467-020-18991-8PMID:33067458
  2. Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility. Harding, CR, Sidik, SM, Petrova, B, Gnädig, NF, Okombo, J, Herneisen, AL, Ward, KE, Markus, BM, Boydston, EA, Fidock, DA et al.. 2020. Nat Commun 11, 4813.
    doi: 10.1038/s41467-020-18624-0PMID:32968076
  3. Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling. Herneisen, AL, Sidik, SM, Markus, BM, Drewry, DH, Zuercher, WJ, Lourido, S. 2020. ACS Chem Biol 15, 1801-1807.
    doi: 10.1021/acschembio.0c00369PMID:32597628
  4. A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells. Ray, GJ, Boydston, EA, Shortt, E, Wyant, GA, Lourido, S, Chen, WW, Sabatini, DM. 2020. iScience 23, 101109.
    doi: 10.1016/j.isci.2020.101109PMID:32417403
  5. Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism. Krishnan, A, Kloehn, J, Lunghi, M, Chiappino-Pepe, A, Waldman, BS, Nicolas, D, Varesio, E, Hehl, A, Lourido, S, Hatzimanikatis, V et al.. 2020. Cell Host Microbe 27, 290-306.e11.
    doi: 10.1016/j.chom.2020.01.002PMID:31991093
  6. Identification of a Master Regulator of Differentiation in Toxoplasma. Waldman, BS, Schwarz, D, Wadsworth, MH 2nd, Saeij, JP, Shalek, AK, Lourido, S. 2020. Cell 180, 359-372.e16.
    doi: 10.1016/j.cell.2019.12.013PMID:31955846
  7. Plate-Based Quantification of Stimulated Toxoplasma Egress. Shortt, E, Lourido, S. 2020. Methods Mol Biol 2071, 171-186.
    doi: 10.1007/978-1-4939-9857-9_10PMID:31758453
  8. High-Throughput Measurement of Microneme Secretion in Toxoplasma gondii. Brown, KM, Sibley, LD, Lourido, S. 2020. Methods Mol Biol 2071, 157-169.
    doi: 10.1007/978-1-4939-9857-9_9PMID:31758452
  9. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Sangaré, LO, Ólafsson, EB, Wang, Y, Yang, N, Julien, L, Camejo, A, Pesavento, P, Sidik, SM, Lourido, S, Barragan, A et al.. 2019. Cell Host Microbe 26, 478-492.e8.
    doi: 10.1016/j.chom.2019.09.008PMID:31600500
  10. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Paredes-Santos, T, Wang, Y, Waldman, B, Lourido, S, Saeij, JP. 2019. Front Cell Infect Microbiol 9, 321.
    doi: 10.3389/fcimb.2019.00321PMID:31572690
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Photo credit: Gretchen Ertl/Whitehead Institute