Sebastian Lourido

Sebastian Lourido

Latham Family Career Development Professor; Member, Whitehead Institute

Sebastian Lourido exposes parasite vulnerabilities and harnesses them to treat infectious disease.





Gabrielle McCauley



Assistant Phone


  • PhD, 2012, Washington University in St. Louis
  • BS, 2004, Cellular and Molecular Biology and Studio Art, Tulane University

Research Summary

Our lab is interested in the molecular events that enable apicomplexan parasites to remain widespread and deadly infectious agents. We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum. We seek to expand our understanding of eukaryotic diversity and identify specific features that can be targeted to treat parasite infections.

Recent Publications

  1. Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism. Krishnan, A, Kloehn, J, Lunghi, M, Chiappino-Pepe, A, Waldman, BS, Nicolas, D, Varesio, E, Hehl, A, Lourido, S, Hatzimanikatis, V et al.. 2020. Cell Host Microbe 27, 290-306.e11.
    doi: 10.1016/j.chom.2020.01.002PMID:31991093
  2. Identification of a Master Regulator of Differentiation in Toxoplasma. Waldman, BS, Schwarz, D, Wadsworth, MH 2nd, Saeij, JP, Shalek, AK, Lourido, S. 2020. Cell 180, 359-372.e16.
    doi: 10.1016/j.cell.2019.12.013PMID:31955846
  3. Plate-Based Quantification of Stimulated Toxoplasma Egress. Shortt, E, Lourido, S. 2020. Methods Mol. Biol. 2071, 171-186.
    doi: 10.1007/978-1-4939-9857-9_10PMID:31758453
  4. High-Throughput Measurement of Microneme Secretion in Toxoplasma gondii. Brown, KM, Sibley, LD, Lourido, S. 2020. Methods Mol. Biol. 2071, 157-169.
    doi: 10.1007/978-1-4939-9857-9_9PMID:31758452
  5. In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. Sangaré, LO, Ólafsson, EB, Wang, Y, Yang, N, Julien, L, Camejo, A, Pesavento, P, Sidik, SM, Lourido, S, Barragan, A et al.. 2019. Cell Host Microbe 26, 478-492.e8.
    doi: 10.1016/j.chom.2019.09.008PMID:31600500
  6. The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability. Paredes-Santos, T, Wang, Y, Waldman, B, Lourido, S, Saeij, JP. 2019. Front Cell Infect Microbiol 9, 321.
    doi: 10.3389/fcimb.2019.00321PMID:31572690
  7. Toxoplasma gondii. Lourido, S. 2019. Trends Parasitol. 35, 944-945.
    doi: 10.1016/
  8. Optimizing Systems for Cas9 Expression in Toxoplasma gondii. Markus, BM, Bell, GW, Lorenzi, HA, Lourido, S. 2019. mSphere 4, .
    doi: 10.1128/mSphere.00386-19PMID:31243081
  9. Alveolar proteins stabilize cortical microtubules in Toxoplasma gondii. Harding, CR, Gow, M, Kang, JH, Shortt, E, Manalis, SR, Meissner, M, Lourido, S. 2019. Nat Commun 10, 401.
    doi: 10.1038/s41467-019-08318-7PMID:30674885
  10. Identification of cryptic subunits from an apicomplexan ATP synthase. Huet, D, Rajendran, E, van Dooren, GG, Lourido, S. 2018. Elife 7, .
    doi: 10.7554/eLife.38097PMID:30204085
More Publications




Photo credit: Gretchen Ertl/Whitehead Institute