Sebastian Lourido

Sebastian Lourido

Associate Professor of Biology; Core Member, Whitehead Institute

Sebastian Lourido exposes parasite vulnerabilities and harnesses them to treat infectious disease.

617-324-4920

Phone

WI-661G

Office

lourido@wi.mit.edu

Email

Whitehead Institute for Biomedical Research

Location

Lab Website
Emily Shortt

Assistant

617-258-5251

Assistant Phone

Education

  • PhD, 2012, Washington University in St. Louis
  • BS, 2004, Cellular and Molecular Biology and Studio Art, Tulane University

Research Summary

Our lab is interested in the molecular events that enable apicomplexan parasites to remain widespread and deadly infectious agents. We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum. We seek to expand our understanding of eukaryotic diversity and identify specific features that can be targeted to treat parasite infections.

Awards

  • Odyssey Award, Smith Family Foundation, 2021

Recent Publications

  1. Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient Mutants. Rimple, PA, Olafsson, EB, Markus, BM, Wang, F, Augusto, L, Lourido, S, Carruthers, VB. 2024. bioRxiv , .
    doi: 10.1101/2024.11.27.625683PMID:39651188
  2. Perforation of the host cell plasma membrane during Toxoplasma gondii invasion requires rhoptry exocytosis. Male, F, Kegawa, Y, Blank, PS, Jiménez-Munguía, I, Sidik, SM, Valleau, D, Lourido, S, Lebrun, M, Zimmerberg, J, Ward, GE et al.. 2024. bioRxiv , .
    doi: 10.1101/2024.10.12.618018PMID:39605356
  3. TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii. Thaprawat, P, Zhang, Z, Rentchler, EC, Wang, F, Chalasani, S, Giuliano, CJ, Lourido, S, Di Cristina, M, Klionsky, DJ, Carruthers, VB et al.. 2024. Autophagy Rep 3, .
    doi: 10.1080/27694127.2024.2418256PMID:39600488
  4. SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle. Herneisen, AL, Peters, ML, Smith, TA, Shortt, E, Lourido, S. 2024. Elife 13, .
    doi: 10.7554/eLife.93877PMID:39136687
  5. TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii. Thaprawat, P, Zhang, Z, Rentchler, EC, Wang, F, Chalasani, S, Giuliano, CJ, Lourido, S, Di Cristina, M, Klionsky, DJ, Carruthers, VB et al.. 2024. bioRxiv , .
    doi: 10.1101/2024.07.08.602581PMID:39026823
  6. CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection. Giuliano, CJ, Wei, KJ, Harling, FM, Waldman, BS, Farringer, MA, Boydston, EA, Lan, TCT, Thomas, RW, Herneisen, AL, Sanderlin, AG et al.. 2024. Nat Microbiol 9, 2323-2343.
    doi: 10.1038/s41564-024-01754-2PMID:38977907
  7. Author Correction: CRISPR-Cas9-based genome-wide screening of Toxoplasma gondii. Sidik, SM, Huet, D, Lourido, S. 2024. Nat Protoc , .
    doi: 10.1038/s41596-024-01018-7PMID:38834920
  8. Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors. Wang, F, Holmes, MJ, Hong, HJ, Thaprawat, P, Kannan, G, Huynh, MH, Schultz, TL, Licon, MH, Lourido, S, Dong, W et al.. 2024. Nat Commun 15, 4385.
    doi: 10.1038/s41467-024-48685-4PMID:38782906
  9. Discovery of antibiotics that selectively kill metabolically dormant bacteria. Zheng, EJ, Valeri, JA, Andrews, IW, Krishnan, A, Bandyopadhyay, P, Anahtar, MN, Herneisen, A, Schulte, F, Linnehan, B, Wong, F et al.. 2024. Cell Chem Biol 31, 712-728.e9.
    doi: 10.1016/j.chembiol.2023.10.026PMID:38029756
  10. SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle. Herneisen, AL, Peters, ML, Smith, TA, Shortt, E, Lourido, S. 2024. bioRxiv , .
    doi: 10.1101/2023.10.30.564746PMID:37961644
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Photo credit: Gretchen Ertl/Whitehead Institute