Sallie (Penny) W. Chisholm

Sallie (Penny) W. Chisholm

Institute Professor

Sallie (Penny) W. Chisholm studies the biology, ecology, and evolution of the single most abundant marine phytoplankton species in order to understand the forces that shape microbial ecosystems.

617-253-1771

Phone

48-419

Office

chisholm@mit.edu

Email

Lab Website
Tyler Sousa

Assistant

​617-258-8993

Assistant Phone

Education

  • PhD, 1974, SUNY Albany

Research Summary

Our goal is to understand the ecology and evolution of ocean microbes and how they influence global biogeochemical cycles. We focus on the cyanobacterium Prochlorococcus, which is the smallest and most abundant microbe in ocean ecosystems — sometimes accounting for half the total photosynthetic biomass. We use this model system to study life across all scales — from the genome to the ecosystem.

Awards

  • Crafoord Prize, 2019
  • Generalitat of Catalonia, Ramon Margalef Prize in Ecology, 2013
  • American Association for the Advancement of Science, Fellow, 2012
  • National Medal of Science, 2011
  • National Academy of Sciences, Alexander Agassiz Medal, 2010
  • National Academy of Sciences, Member, 2003
  • John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1997
  • American Academy of Arts and Sciences, Fellow, 1992

Key Publications

  1. Metabolic evolution and the self-organization of ecosystems. Braakman, R, Follows, MJ, Chisholm, SW. 2017. Proc Natl Acad Sci U S A 114, E3091-E3100.
    doi: 10.1073/pnas.1619573114PMID:28348231
  2. Prochlorococcus: the structure and function of collective diversity. Biller, SJ, Berube, PM, Lindell, D, Chisholm, SW. 2015. Nat Rev Microbiol 13, 13-27.
    doi: 10.1038/nrmicro3378PMID:25435307
  3. Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus. Kashtan, N, Roggensack, SE, Rodrigue, S, Thompson, JW, Biller, SJ, Coe, A, Ding, H, Marttinen, P, Malmstrom, RR, Stocker, R et al.. 2014. Science 344, 416-20.
    doi: 10.1126/science.1248575PMID:24763590
  4. Bacterial vesicles in marine ecosystems. Biller, SJ, Schubotz, F, Roggensack, SE, Thompson, AW, Summons, RE, Chisholm, SW. 2014. Science 343, 183-6.
    doi: 10.1126/science.1243457PMID:24408433

Recent Publications

  1. Chitin degradation by Synechococcus WH7803. Capovilla, G, Castro, KG, Collani, S, Kearney, SM, Kehoe, DM, Chisholm, SW. 2023. Sci Rep 13, 19944.
    doi: 10.1038/s41598-023-47332-0PMID:37968300
  2. Production and cross-feeding of nitrite within Prochlorococcus populations. Berube, PM, O'Keefe, TJ, Rasmussen, A, LeMaster, T, Chisholm, SW. 2023. mBio 14, e0123623.
    doi: 10.1128/mbio.01236-23PMID:37404012
  3. Environmental and Taxonomic Drivers of Bacterial Extracellular Vesicle Production in Marine Ecosystems. Biller, SJ, Coe, A, Arellano, AA, Dooley, K, Silvestri, SM, Gong, JS, Yeager, EA, Becker, JW, Chisholm, SW. 2023. Appl Environ Microbiol 89, e0059423.
    doi: 10.1128/aem.00594-23PMID:37199672
  4. Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle. Capovilla, G, Braakman, R, Fournier, GP, Hackl, T, Schwartzman, J, Lu, X, Yelton, A, Longnecker, K, Soule, MCK, Thomas, E et al.. 2023. Proc Natl Acad Sci U S A 120, e2213271120.
    doi: 10.1073/pnas.2213271120PMID:37159478
  5. Draft genomes of three closely related low light-adapted Prochlorococcus. Berta-Thompson, JW, Thomas, E, Cubillos-Ruiz, A, Hackl, T, Becker, JW, Coe, A, Biller, SJ, Berube, PM, Chisholm, SW. 2023. BMC Genom Data 24, 11.
    doi: 10.1186/s12863-022-01103-4PMID:36829130
  6. Novel integrative elements and genomic plasticity in ocean ecosystems. Hackl, T, Laurenceau, R, Ankenbrand, MJ, Bliem, C, Cariani, Z, Thomas, E, Dooley, KD, Arellano, AA, Hogle, SL, Berube, P et al.. 2023. Cell 186, 47-62.e16.
    doi: 10.1016/j.cell.2022.12.006PMID:36608657
  7. Filter Plating Method for Rendering Picocyanobacteria Cultures Free of Heterotrophic Bacterial Contaminants and Clonal. Kearney, SM, Coe, A, Castro, KG, Chisholm, SW. 2022. Front Microbiol 13, 821803.
    doi: 10.3389/fmicb.2022.821803PMID:35250937
  8. Siderophores as an iron source for picocyanobacteria in deep chlorophyll maximum layers of the oligotrophic ocean. Hogle, SL, Hackl, T, Bundy, RM, Park, J, Satinsky, B, Hiltunen, T, Biller, S, Berube, PM, Chisholm, SW. 2022. ISME J 16, 1636-1646.
    doi: 10.1038/s41396-022-01215-wPMID:35241788
  9. Prochlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbes. Biller, SJ, Lundeen, RA, Hmelo, LR, Becker, KW, Arellano, AA, Dooley, K, Heal, KR, Carlson, LT, Van Mooy, BAS, Ingalls, AE et al.. 2022. Environ Microbiol 24, 420-435.
    doi: 10.1111/1462-2920.15834PMID:34766712
  10. Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation. Coe, A, Biller, SJ, Thomas, E, Boulias, K, Bliem, C, Arellano, A, Dooley, K, Rasmussen, AN, LeGault, K, O'Keefe, TJ et al.. 2021. Limnol Oceanogr 66, 3300-3312.
    doi: 10.1002/lno.11880PMID:34690365
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Photo credit: Richard Howard