Education
- Dr. rer. nat., 1985, University of Tübingen
- MS, 1981, Biology, University of Freiburg
Research Summary
We study germ cells, the only cells in the body naturally able to generate completely new organisms. In addition to the nuclear genome, cytoplasmic information is passed though the egg cell to the next generation. We analyze the organization and regulation of germ line specific RNA-protein condensates, and explore mechanisms used by endosymbionts such as mitochondria and the intracellular bacterium, Wolbachia, to propagate through the cytoplasm of the female germ line.Awards
- Vanderbilt Prize in Biomedical Science, 2022
- Gruber Genetics Prize, 2022
- Thomas Hunt Morgan Medal, Genetics Society of America, 2021
- Francis Amory Prize in Reproductive Medicine and Reproductive Physiology, American Academy of Arts and Sciences, 2020
- Vilcek Prize in Biomedical Science, 2020
- Keith R. Porter Award, American Society for Cell Biology, 2018
- Inaugural Klaus Sander Prize, German Society for Developmental Biology, 2017
- European Molecular Biology Organization, Foreign Associate, 2012
- Conklin Medal of the Society of Developmental Biology, 2011
- National Academy of Sciences, Foreign Associate, 2005; Member, 2008
- American Academy of Arts and Sciences, Member, 1998
- Howard Hughes Medical Institute, Investigator, 1990 and 1997
Key Publications
Recent Publications
- Origin and establishment of the germline in Drosophila melanogaster. Chen, R, Grill, S, Lin, B, Saiduddin, M, Lehmann, R. 2025. Genetics 229, .
doi: 10.1093/genetics/iyae217PMID:40180587 - Boosting the toolbox for live imaging of translation. Bellec, M, Chen, R, Dhayni, J, Trullo, A, Avinens, D, Karaki, H, Mazzarda, F, Lenden-Hasse, H, Favard, C, Lehmann, R et al.. 2024. RNA 30, 1374-1394.
doi: 10.1261/rna.080140.124PMID:39060168 - Publisher Correction: How germ granules promote germ cell fate. Pamula, MC, Lehmann, R. 2024. Nat Rev Genet 25, 822.
doi: 10.1038/s41576-024-00764-4PMID:38982240 - Direct observation of translational activation by a ribonucleoprotein granule. Chen, R, Stainier, W, Dufourt, J, Lagha, M, Lehmann, R. 2024. Nat Cell Biol 26, 1322-1335.
doi: 10.1038/s41556-024-01452-5PMID:38965420 - How germ granules promote germ cell fate. Pamula, MC, Lehmann, R. 2024. Nat Rev Genet 25, 803-821.
doi: 10.1038/s41576-024-00744-8PMID:38890558 - Juvenile hormones direct primordial germ cell migration to the embryonic gonad. Barton, LJ, Sanny, J, Packard Dawson, E, Nouzova, M, Noriega, FG, Stadtfeld, M, Lehmann, R. 2024. Curr Biol 34, 505-518.e6.
doi: 10.1016/j.cub.2023.12.033PMID:38215744 - HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare. Grill, S, Riley, A, Selvaraj, M, Lehmann, R. 2023. Proc Natl Acad Sci U S A 120, e2309478120.
doi: 10.1073/pnas.2309478120PMID:37725638 - An AMPK phosphoregulated RhoGEF feedback loop tunes cortical flow-driven amoeboid migration in vivo. Lin, B, Luo, J, Lehmann, R. 2022. Sci Adv 8, eabo0323.
doi: 10.1126/sciadv.abo0323PMID:36103538 - Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Li, H, Janssens, J, De Waegeneer, M, Kolluru, SS, Davie, K, Gardeux, V, Saelens, W, David, FPA, Brbić, M, Spanier, K et al.. 2022. Science 375, eabk2432.
doi: 10.1126/science.abk2432PMID:35239393 - Model organism databases are in jeopardy. Bellen, HJ, Hubbard, EJA, Lehmann, R, Madhani, HD, Solnica-Krezel, L, Southard-Smith, EM. 2021. Development 148, .
doi: 10.1242/dev.200193PMID:35231122
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