Ruth Lehmann

Ruth Lehmann

Professor of Biology; Director, Whitehead Institute

Ruth Lehmann studies the biological origins of germ cells, and how they transmit the potential to build a completely new organism to their offspring.

617-324-0212

Phone

WI-361

Office

Nancy Rodriguez

Assistant

212-263-2989

Assistant Phone

Education

  • Dr. rer. nat., 1985, University of Tübingen
  • MS, 1981, Biology, University of Freiburg

Research Summary

We study germ cells, the only cells in the body naturally able to generate completely new organisms. In addition to the nuclear genome, cytoplasmic information is passed though the egg cell to the next generation. We analyze the organization and regulation of germ line specific RNA-protein condensates, and explore mechanisms used by endosymbionts such as mitochondria and the intracellular bacterium, Wolbachia, to propagate through the cytoplasm of the female germ line.

Awards

  • Vilcek Prize in Biomedical Science, 2020
  • Keith R. Porter Award, American Society for Cell Biology, 2018
  • Inaugural Klaus Sander Prize, German Society for Developmental Biology, 2017
  • European Molecular Biology Organization, Foreign Associate, 2012
  • Conklin Medal of the Society of Developmental Biology, 2011
  • National Academy of Sciences, Foreign Associate, 2005; Member, 2008
  • American Academy of Arts and Sciences, Member, 1998
  • Howard Hughes Medical Institute, Investigator, 1990 and 1997

Key Publications

  1. Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters. Trcek, T, Douglas, TE, Grosch, M, Yin, Y, Eagle, WVI, Gavis, ER, Shroff, H, Rothenberg, E, Lehmann, R. 2020. Mol Cell 78, 941-950.e12.
    doi: 10.1016/j.molcel.2020.05.008PMID:32464092
  2. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber, T, Jeedigunta, SP, Palozzi, JM, Lehmann, R, Hurd, TR. 2019. Nature 570, 380-384.
    doi: 10.1038/s41586-019-1213-4PMID:31092924
  3. Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. Grobler, Y, Yun, CY, Kahler, DJ, Bergman, CM, Lee, H, Oliver, B, Lehmann, R. 2018. PLoS Pathog 14, e1007445.
    doi: 10.1371/journal.ppat.1007445PMID:30422992
  4. Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells. Kistler, KE, Trcek, T, Hurd, TR, Chen, R, Liang, FX, Sall, J, Kato, M, Lehmann, R. 2018. Elife 7, .
    doi: 10.7554/eLife.37949PMID:30260314
  5. piRNA-mediated regulation of transposon alternative splicing in the soma and germ line. Teixeira, FK, Okuniewska, M, Malone, CD, Coux, RX, Rio, DC, Lehmann, R. 2017. Nature 552, 268-272.
    doi: 10.1038/nature25018PMID:29211718
  6. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. Pae, J, Cinalli, RM, Marzio, A, Pagano, M, Lehmann, R. 2017. Dev Cell 42, 130-142.e7.
    doi: 10.1016/j.devcel.2017.06.022PMID:28743001
  7. Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster. Hurd, TR, Herrmann, B, Sauerwald, J, Sanny, J, Grosch, M, Lehmann, R. 2016. Dev Cell 39, 560-571.
    doi: 10.1016/j.devcel.2016.11.004PMID:27923120

Recent Publications

  1. Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters. Trcek, T, Douglas, TE, Grosch, M, Yin, Y, Eagle, WVI, Gavis, ER, Shroff, H, Rothenberg, E, Lehmann, R. 2020. Mol Cell 78, 941-950.e12.
    doi: 10.1016/j.molcel.2020.05.008PMID:32464092
  2. A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. Slaidina, M, Banisch, TU, Gupta, S, Lehmann, R. 2020. Genes Dev 34, 239-249.
    doi: 10.1101/gad.330464.119PMID:31919193
  3. Germ granules in Drosophila. Trcek, T, Lehmann, R. 2019. Traffic 20, 650-660.
    doi: 10.1111/tra.12674PMID:31218815
  4. Preface. Lehmann, R. 2019. Curr Top Dev Biol 135, xi-xiv.
    doi: 10.1016/S0070-2153(19)30066-3PMID:31155365
  5. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber, T, Jeedigunta, SP, Palozzi, JM, Lehmann, R, Hurd, TR. 2019. Nature 570, 380-384.
    doi: 10.1038/s41586-019-1213-4PMID:31092924
  6. Human organoids: a new dimension in cell biology. Lehmann, R, Lee, CM, Shugart, EC, Benedetti, M, Charo, RA, Gartner, Z, Hogan, B, Knoblich, J, Nelson, CM, Wilson, KM et al.. 2019. Mol Biol Cell 30, 1129-1137.
    doi: 10.1091/mbc.E19-03-0135PMID:31034354
  7. Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. Grobler, Y, Yun, CY, Kahler, DJ, Bergman, CM, Lee, H, Oliver, B, Lehmann, R. 2018. PLoS Pathog 14, e1007445.
    doi: 10.1371/journal.ppat.1007445PMID:30422992
  8. Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells. Kistler, KE, Trcek, T, Hurd, TR, Chen, R, Liang, FX, Sall, J, Kato, M, Lehmann, R. 2018. Elife 7, .
    doi: 10.7554/eLife.37949PMID:30260314
  9. Meeting report: mobile genetic elements and genome plasticity 2018. Abrams, JM, Arkhipova, IR, Belfort, M, Boeke, JD, Joan Curcio, M, Faulkner, GJ, Goodier, JL, Lehmann, R, Levin, HL. 2018. Mob DNA 9, 21.
    doi: 10.1186/s13100-018-0126-3PMID:30211913
  10. Matchmaking molecule for egg and sperm. Lehmann, R. 2018. Science 361, 974-975.
    doi: 10.1126/science.aau8356PMID:30190390
More Publications

Multimedia

 

Photo credit: Courtesy of Ruth Lehmann