Robert A. Weinberg

Robert A. Weinberg

Daniel K. Ludwig Professor for Cancer Research; Member, Whitehead Institute

Robert A. Weinberg studies how cancer spreads, what gives cancer stem-cells their unique qualities, and the molecular players involved in the formation of cancer stem cells and metastases.

617-258-5159

Phone

WI-301

Office

Christine Hickey

Assistant

617-258-5158

Assistant Phone

Education

  • PhD, 1969, MIT
  • SB, 1964, Biology, MIT

Research Summary

We investigate three broad questions related to the origin and spread of cancer. First, how do cancer cells within a primary tumor acquire the ability to invade and metastasize? Second, how are the stem-cell state and the epithelial-mesenchymal transition interrelated? Third, how are the regulators of the epithelial-mesenchymal transition able to activate this profound change in cell phenotype?

Awards

  • Breakthrough Prize in Life Sciences, 2013
  • Wolf Foundation Prize, 2004
  • Institute of Medicine, Member, 2000
  • Keio Medical Science Foundation Prize, 1997
  • National Science Foundation, National Medal of Science, 1997
  • Harvey Prize, 1994
  • American Academy of Arts and Sciences, Fellow, 1987
  • Sloan Prize, GM Cancer Research Foundation, 1987
  • National Academy of Sciences, Member, 1985
  • Robert Koch Foundation Prize, 1983

Key Publications

  1. The epithelial-mesenchymal transition generates cells with properties of stem cells. Mani, SA, Guo, W, Liao, MJ, Eaton, EN, Ayyanan, A, Zhou, AY, Brooks, M, Reinhard, F, Zhang, CC, Shipitsin, M et al.. 2008. Cell 133, 704-15.
    doi: 10.1016/j.cell.2008.03.027PMID:18485877
  2. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Yang, J, Mani, SA, Donaher, JL, Ramaswamy, S, Itzykson, RA, Come, C, Savagner, P, Gitelman, I, Richardson, A, Weinberg, RA. 2004. Cell 117, 927-39.
    doi: 10.1016/j.cell.2004.06.006PMID:15210113
  3. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Friend, SH, Bernards, R, Rogelj, S, Weinberg, RA, Rapaport, JM, Albert, DM, Dryja, TP. Nature 323, 643-6.
    doi: 10.1038/323643a0PMID:2877398
  4. Mechanism of activation of a human oncogene. Tabin, CJ, Bradley, SM, Bargmann, CI, Weinberg, RA, Papageorge, AG, Scolnick, EM, Dhar, R, Lowy, DR, Chang, EH. 1982. Nature 300, 143-9.
    PMID:6290897
  5. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Shih, C, Padhy, LC, Murray, M, Weinberg, RA. 1981. Nature 290, 261-4.
    PMID:7207618

Recent Publications

  1. EMT and Cancer: More Than Meets the Eye. Derynck, R, Weinberg, RA. 2019. Dev. Cell 49, 313-316.
    doi: 10.1016/j.devcel.2019.04.026PMID:31063750
  2. Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells. Kröger, C, Afeyan, A, Mraz, J, Eaton, EN, Reinhardt, F, Khodor, YL, Thiru, P, Bierie, B, Ye, X, Burge, CB et al.. 2019. Proc. Natl. Acad. Sci. U.S.A. 116, 7353-7362.
    doi: 10.1073/pnas.1812876116PMID:30910979
  3. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Dongre, A, Weinberg, RA. 2019. Nat. Rev. Mol. Cell Biol. 20, 69-84.
    doi: 10.1038/s41580-018-0080-4PMID:30459476
  4. Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling. Fröse, J, Chen, MB, Hebron, KE, Reinhardt, F, Hajal, C, Zijlstra, A, Kamm, RD, Weinberg, RA. 2018. Cell Rep 24, 962-972.
    doi: 10.1016/j.celrep.2018.06.092PMID:30044991
  5. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Krall, JA, Reinhardt, F, Mercury, OA, Pattabiraman, DR, Brooks, MW, Dougan, M, Lambert, AW, Bierie, B, Ploegh, HL, Dougan, SK et al.. 2018. Sci Transl Med 10, .
    doi: 10.1126/scitranslmed.aan3464PMID:29643230
  6. The SUMO guards for SNAIL. Ye, X, Weinberg, RA. 2017. Oncotarget 8, 97701-97702.
    doi: 10.18632/oncotarget.22432PMID:29231927
  7. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen, VJ, Chavarria, TE, Kröger, C, Ye, X, Weinberg, RA, Lees, JA. 2017. Proc. Natl. Acad. Sci. U.S.A. 114, E10532-E10539.
    doi: 10.1073/pnas.1711534114PMID:29158396
  8. Upholding a role for EMT in pancreatic cancer metastasis. Aiello, NM, Brabletz, T, Kang, Y, Nieto, MA, Weinberg, RA, Stanger, BZ. 2017. Nature 547, E7-E8.
    doi: 10.1038/nature22963PMID:28682339
  9. Upholding a role for EMT in breast cancer metastasis. Ye, X, Brabletz, T, Kang, Y, Longmore, GD, Nieto, MA, Stanger, BZ, Yang, J, Weinberg, RA. 2017. Nature 547, E1-E3.
    doi: 10.1038/nature22816PMID:28682326
  10. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. Rashidian, M, Ingram, JR, Dougan, M, Dongre, A, Whang, KA, LeGall, C, Cragnolini, JJ, Bierie, B, Gostissa, M, Gorman, J et al.. 2017. J. Exp. Med. 214, 2243-2255.
    doi: 10.1084/jem.20161950PMID:28666979
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Photo credit: Gretchen Ertl/Whitehead Institute