Rebecca Lamason

Rebecca Lamason

Assistant Professor

Rebecca Lamason investigates what happens when cellular functions are hijacked by unwanted interlopers: namely, the bacteria that engender diseases like spotted fever and meningitis.

617-258-6155

Phone

68-670A

Office

Gina Lee

Assistant

617-258-6473

Assistant Phone

Education

PhD 2011, The Johns Hopkins University School of Medicine

Research Summary

In the Lamason lab, we investigate how intracellular bacterial pathogens hijack host cell processes to promote infection. In particular, we study how Rickettsia parkeri and Listeria monocytogenes move through our tissues via a process called cell-to-cell spread. We utilize cellular, molecular, genetic, biochemical and biophysical approaches to elucidate the mechanisms of spread in order to reveal key aspects of pathogenesis and host cell biology.

Awards

  • NIH Pathway to Independence Award, 2015

Recent Publications

  1. Actin-based motility and cell-to-cell spread of bacterial pathogens. Lamason, RL, Welch, MD. 2017. Curr. Opin. Microbiol. 35, 48-57.
    doi: 10.1016/j.mib.2016.11.007PMID:27997855
  2. Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread. Lamason, RL, Bastounis, E, Kafai, NM, Serrano, R, Del Álamo, JC, Theriot, JA, Welch, MD. 2016. Cell 167, 670-683.e10.
    doi: 10.1016/j.cell.2016.09.023PMID:27768890
  3. Rickettsia actin-based motility occurs in distinct phases mediated by different actin nucleators. Reed, SC, Lamason, RL, Risca, VI, Abernathy, E, Welch, MD. 2014. Curr. Biol. 24, 98-103.
    doi: 10.1016/j.cub.2013.11.025PMID:24361066
  4. Expression of an epitope-tagged virulence protein in Rickettsia parkeri using transposon insertion. Welch, MD, Reed, SC, Lamason, RL, Serio, AW. 2012. PLoS ONE 7, e37310.
    doi: 10.1371/journal.pone.0037310PMID:22624012
  5. The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN. Lamason, RL, Kupfer, A, Pomerantz, JL. 2010. Mol. Cell 40, 798-809.
    doi: 10.1016/j.molcel.2010.11.007PMID:21145487
  6. Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain. Lamason, RL, McCully, RR, Lew, SM, Pomerantz, JL. 2010. Biochemistry 49, 8240-50.
    doi: 10.1021/bi101052dPMID:20799731
  7. Transcriptional target-based expression cloning of immunoregulatory molecules. Lamason, RL, Lew, SM, Pomerantz, JL. 2010. Immunol. Res. 47, 172-8.
    doi: 10.1007/s12026-009-8148-zPMID:20069388
  8. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Lamason, RL, Mohideen, MA, Mest, JR, Wong, AC, Norton, HL, Aros, MC, Jurynec, MJ, Mao, X, Humphreville, VR, Humbert, JE et al.. 2005. Science 310, 1782-6.
    doi: 10.1126/science.1116238PMID:16357253
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