Pulin Li

Pulin Li

Assistant Professor of Biology; Member, Whitehead Institute

Pulin Li is interested in quantitatively understanding how genetic circuits create multicellular behavior in both natural and synthetically engineered systems.

617-452-4235

Phone

WI-601A

Office

Laura Resteghini

Assistant

617-258-7778

Assistant Phone

Education

  • PhD, 2012, Chemical Biology, Harvard University
  • BS, 2006, Life Sciences, Peking University

Research Summary

We are curious about how circuits of interacting genes in individual cells enable multicellular functions, such as self-organizing into structured tissues. To address this question, we analyze genetic circuits in natural systems, combining quantitative measurements and mathematical modeling. In parallel, we test the sufficiency of the circuits and understand their design principles by multi-scale reconstitution, from genes to circuits to multicellular behavior, using synthetic biology and bioengineering tools. Together, we aim to provide both a quantitative understanding of embryonic development and new ways to engineer tissues.

Awards

  • Santa Cruz Developmental Biology Young Investigator Award, 2016
  • NIH Pathway to Independence Award K99/R00 (NICHD), 2016
  • American Cancer Society Postdoctoral Fellowship, 2015

Recent Publications

  1. Communication codes in developmental signaling pathways. Li, P, Elowitz, MB. 2019. Development 146, .
    doi: 10.1242/dev.170977PMID:31249008
  2. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Lahvic, JL, Ammerman, M, Li, P, Blair, MC, Stillman, ER, Fast, EM, Robertson, AL, Christodoulou, C, Perlin, JR, Yang, S et al.. 2018. Proc. Natl. Acad. Sci. U.S.A. 115, 9252-9257.
    doi: 10.1073/pnas.1806077115PMID:30139917
  3. Morphogen gradient reconstitution reveals Hedgehog pathway design principles. Li, P, Markson, JS, Wang, S, Chen, S, Vachharajani, V, Elowitz, MB. 2018. Science 360, 543-548.
    doi: 10.1126/science.aao0645PMID:29622726
  4. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Li, P, Lahvic, JL, Binder, V, Pugach, EK, Riley, EB, Tamplin, OJ, Panigrahy, D, Bowman, TV, Barrett, FG, Heffner, GC et al.. 2015. Nature 523, 468-71.
    doi: 10.1038/nature14569PMID:26201599
  5. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Tamplin, OJ, Durand, EM, Carr, LA, Childs, SJ, Hagedorn, EJ, Li, P, Yzaguirre, AD, Speck, NA, Zon, LI. 2015. Cell 160, 241-52.
    doi: 10.1016/j.cell.2014.12.032PMID:25594182
  6. Small molecule screening in zebrafish: swimming in potential drug therapies. Tamplin, OJ, White, RM, Jing, L, Kaufman, CK, Lacadie, SA, Li, P, Taylor, AM, Zon, LI. Wiley Interdiscip Rev Dev Biol 1, 459-68.
    doi: 10.1002/wdev.37PMID:23801494
  7. An optical platform for cell tracking in adult zebrafish. Zhang, L, Alt, C, Li, P, White, RM, Zon, LI, Wei, X, Lin, CP. 2012. Cytometry A 81, 176-82.
    doi: 10.1002/cyto.a.21167PMID:22162445
  8. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Trompouki, E, Bowman, TV, Lawton, LN, Fan, ZP, Wu, DC, DiBiase, A, Martin, CS, Cech, JN, Sessa, AK, Leblanc, JL et al.. 2011. Cell 147, 577-89.
    doi: 10.1016/j.cell.2011.09.044PMID:22036566
  9. Transplantation in zebrafish. Li, P, White, RM, Zon, LI. 2011. Methods Cell Biol. 105, 403-17.
    doi: 10.1016/B978-0-12-381320-6.00017-5PMID:21951540
  10. Stem cell migration: a zebrafish model. Li, P, Zon, LI. 2011. Methods Mol. Biol. 750, 157-68.
    doi: 10.1007/978-1-61779-145-1_11PMID:21618090

Multimedia

Photo credit: Raleigh McElvery