Education
- PhD, 2008, University of Michigan; MD, 2008, University of Michigan Medical School
- BS, 1999, Biochemistry and Physics, University of Michigan
Research Summary
The adult intestine is maintained by stem cells that require a cellular neighborhood, or niche, consisting in part of Paneth cells. Our laboratory will investigate the molecular mechanisms of how intestinal stem cells and their Paneth cell niche respond to diverse diets to coordinate intestinal regeneration with organismal physiology and its impact on the formation and growth of intestinal cancers. By better understanding how intestinal stem cells adapt to diverse diets, we hope to identify and develop new strategies that prevent and reduce the growth of cancers involving the intestinal tract that includes the small intestine, colon, and rectum.Awards
- AAAS Martin and Rose Wachtel Cancer Research Award, 2018
- Pew-Stewart Trust Scholar, 2016-2020
- Sidney Kimmel Scholar, 2016-2020
- V Foundation Scholar, 2014-2017
- Harold M. Weintraub Award, 2007
Key Publications
Recent Publications
- Dietary and metabolic effects on intestinal stem cells in health and disease. Shay, JES, Yilmaz, ÖH. 2024. Nat Rev Gastroenterol Hepatol , .
doi: 10.1038/s41575-024-00980-7PMID:39358589 - Selecting the Most Relevant Mouse Strains for Evaluating Radiation-Induced Multiple Tissue Injury after Leg-Shielded Partial-Body Gamma Irradiation. Down, JD, Cornwall-Brady, MR, Huang, W, Hurwitz, M, Floyd, SR, Yilmaz, OH. 2024. Radiat Res 202, 510-522.
doi: 10.1667/RADE-24-00058.1PMID:39066627 - β2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma. Lee, SH, Pankaj, A, Rickelt, S, Ting, D, Ferrone, C, Patil, DT, Yilmaz, O, Berger, D, Deshpande, V, Yilmaz, O et al.. 2024. Am J Clin Pathol , .
doi: 10.1093/ajcp/aqae066PMID:38869306 - SOX17 enables immune evasion of early colorectal adenomas and cancers. Goto, N, Westcott, PMK, Goto, S, Imada, S, Taylor, MS, Eng, G, Braverman, J, Deshpande, V, Jacks, T, Agudo, J et al.. 2024. Nature 627, 636-645.
doi: 10.1038/s41586-024-07135-3PMID:38418875 - Microbial regulation of ferroptosis in cancer. Zhang, Q, Goswami, S, Yilmaz, O. 2024. Nat Cell Biol 26, 41-42.
doi: 10.1038/s41556-023-01321-7PMID:38168771 - Dietary fat and lipid metabolism in the tumor microenvironment. Goswami, S, Zhang, Q, Celik, CE, Reich, EM, Yilmaz, ÖH. 2023. Biochim Biophys Acta Rev Cancer 1878, 188984.
doi: 10.1016/j.bbcan.2023.188984PMID:37722512 - Immune microenvironment and lymph node yield in colorectal cancer. Lee, SH, Pankaj, A, Neyaz, A, Ono, Y, Rickelt, S, Ferrone, C, Ting, D, Patil, DT, Yilmaz, O, Berger, D et al.. 2023. Br J Cancer 129, 917-924.
doi: 10.1038/s41416-023-02372-1PMID:37507544 - Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon. Deshpande, V, Lee, SH, Crabbe, A, Pankaj, A, Neyaz, A, Ono, Y, Rickelt, S, Sonal, S, Ferrone, CR, Ting, DT et al.. 2024. J Clin Pathol 77, 387-393.
doi: 10.1136/jcp-2023-208895PMID:37258254 - Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury. Goto, N, Goto, S, Imada, S, Hosseini, S, Deshpande, V, Yilmaz, ÖH. 2022. Cell Stem Cell 29, 1246-1261.e6.
doi: 10.1016/j.stem.2022.06.013PMID:35931033 - Bispecific antibodies seek out colon cancer stem cells. Goto, N, Yilmaz, ÖH. 2022. Nat Cancer 3, 379-380.
doi: 10.1038/s43018-022-00368-zPMID:35469016