- PhD, 2002, Stanford University
- BS, 1997, Molecular Biology, University of California, San Diego
Research SummaryWe study the biological mechanisms and evolution of how cells process information to regulate their own growth and proliferation. Using bacteria as a model organism, we aim to elucidate the detailed molecular basis for this remarkable regulatory capability, and understand the selective pressures and mechanisms that drive the evolution of signaling pathways. Our work is rooted in a desire to develop a deeper, fundamental understanding of how cells function and evolve, but it also has important medical implications since many signaling pathways in pathogenic bacteria are needed for virulence.
- Howard Hughes Medical Institute, HHMI Investigator, 2015
- National Science Foundation, Presidential Early Career Award for Scientists and Engineers, 2010
- Howard Hughes Medical Institute, Early Career Scientist, 2009
- High-resolution, genome-wide mapping of positive supercoiling in chromosomes. Guo, MS, Kawamura, R, Littlehale, ML, Marko, JF, Laub, MT. 2021. Elife 10, .
- Activation of a signaling pathway by the physical translocation of a chromosome. Guzzo, M, Sanderlin, AG, Castro, LK, Laub, MT. 2021. Dev Cell , .
- Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection. Guegler, CK, Laub, MT. 2021. Mol Cell 81, 2361-2373.e9.
- Two-Component Signaling Systems Regulate Diverse Virulence-Associated Traits in Pseudomonas aeruginosa. Wang, BX, Cady, KC, Oyarce, GC, Ribbeck, K, Laub, MT. 2021. Appl Environ Microbiol 87, .
- Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library. Lite, TV, Grant, RA, Nocedal, I, Littlehale, ML, Guo, MS, Laub, MT. 2020. Elife 9, .
- ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. Wang, B, Grant, RA, Laub, MT. 2020. Mol Cell 80, 29-42.e10.
- Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin. LeRoux, M, Culviner, PH, Liu, YJ, Littlehale, ML, Laub, MT. 2020. Mol Cell 79, 280-292.e8.
- Constraints on the expansion of paralogous protein families. McClune, CJ, Laub, MT. 2020. Curr Biol 30, R460-R464.
- A Simple, Cost-Effective, and Robust Method for rRNA Depletion in RNA-Sequencing Studies. Culviner, PH, Guegler, CK, Laub, MT. 2020. mBio 11, .
- A CRISPR Interference System for Efficient and Rapid Gene Knockdown in Caulobacter crescentus. Guzzo, M, Castro, LK, Reisch, CR, Guo, MS, Laub, MT. 2020. mBio 11, .