Michael B. Yaffe

Michael B. Yaffe

Director, MIT Center for Precision Cancer Medicine; David H. Koch Professor in Science; Professor of Biological Engineering

Michael B. Yaffe studies the chain of reactions that controls a cell’s response to stress, cell injury, and DNA damage.

617-452-2442

Phone

76-353

Office

Thomas Dietzel

Assistant

617-452-2103

Assistant Phone

Education

PhD 1987, Case Western Reserve University; MD 1989, Case Western Reserve University

Research Summary

Our goal is to understand how signaling pathways are integrated at the molecular and systems levels to control cellular responses. We have two main focuses: First, we study signaling pathways and networks that control cell cycle progression and DNA damage responses in cancer and cancer therapy. Second, we examine the cross-talk between inflammation, cytokine signaling and cancer. Much of our work focuses on how modular protein domains and kinases work together to build molecular signaling circuits, and how this information can be used to design synergistic drug combinations for the personalized treatment of human disease.

Awards

  • Teaching with Digital Technology Award, 2018

Key Publications

  1. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cannell, IG, Merrick, KA, Morandell, S, Zhu, CQ, Braun, CJ, Grant, RA, Cameron, ER, Tsao, MS, Hemann, MT, Yaffe, MB. 2015. Cancer Cell 28, 623-637.
    doi: 10.1016/j.ccell.2015.09.009PMID:26602816
  2. Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Reinhardt, HC, Yaffe, MB. 2013. Nat. Rev. Mol. Cell Biol. 14, 563-80.
    doi: 10.1038/nrm3640PMID:23969844
  3. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Floyd, SR, Pacold, ME, Huang, Q, Clarke, SM, Lam, FC, Cannell, IG, Bryson, BD, Rameseder, J, Lee, MJ, Blake, EJ et al.. 2013. Nature 498, 246-50.
    doi: 10.1038/nature12147PMID:23728299
  4. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Lee, MJ, Ye, AS, Gardino, AK, Heijink, AM, Sorger, PK, MacBeath, G, Yaffe, MB. 2012. Cell 149, 780-94.
    doi: 10.1016/j.cell.2012.03.031PMID:22579283
  5. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Reinhardt, HC, Hasskamp, P, Schmedding, I, Morandell, S, van Vugt, MA, Wang, X, Linding, R, Ong, SE, Weaver, D, Carr, SA et al.. 2010. Mol. Cell 40, 34-49.
    doi: 10.1016/j.molcel.2010.09.018PMID:20932473

Recent Publications

  1. Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Barrett, CD, Hsu, AT, Ellson, CD, Y Miyazawa, B, Kong, YW, Greenwood, JD, Dhara, S, Neal, MD, Sperry, JL, Park, MS et al.. 2018. Clin. Exp. Immunol. 194, 103-117.
    doi: 10.1111/cei.13166PMID:30260475
  2. Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Creixell, P, Pandey, JP, Palmeri, A, Bhattacharyya, M, Creixell, M, Ranganathan, R, Pincus, D, Yaffe, MB. 2018. Cell Syst 7, 371-383.e4.
    doi: 10.1016/j.cels.2018.08.008PMID:30243563
  3. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Suarez-Lopez, L, Sriram, G, Kong, YW, Morandell, S, Merrick, KA, Hernandez, Y, Haigis, KM, Yaffe, MB. 2018. Proc. Natl. Acad. Sci. U.S.A. 115, E4236-E4244.
    doi: 10.1073/pnas.1722020115PMID:29666270
  4. Predicting the future of signaling for 2018. Yaffe, MB. 2018. Sci Signal 11, .
    doi: 10.1126/scisignal.aar7429PMID:29295956
  5. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. Barrett, CD, Moore, HB, Banerjee, A, Silliman, CC, Moore, EE, Yaffe, MB. 2017. J Trauma Acute Care Surg 83, 1053-1061.
    doi: 10.1097/TA.0000000000001685PMID:28837538
  6. Protein Regulation in Signal Transduction. Lee, MJ, Yaffe, MB. 2016. Cold Spring Harb Perspect Biol 8, .
    doi: 10.1101/cshperspect.a005918PMID:27252361
  7. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Lam, FC, Yaffe, MB. 2016. Cancer Cell 29, 435-436.
    doi: 10.1016/j.ccell.2016.03.022PMID:27070697
  8. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cannell, IG, Merrick, KA, Morandell, S, Zhu, CQ, Braun, CJ, Grant, RA, Cameron, ER, Tsao, MS, Hemann, MT, Yaffe, MB. 2015. Cancer Cell 28, 623-637.
    doi: 10.1016/j.ccell.2015.09.009PMID:26602816
  9. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Hsu, AT, Barrett, CD, DeBusk, GM, Ellson, CD, Gautam, S, Talmor, DS, Gallagher, DC, Yaffe, MB. 2015. Shock 44, 128-36.
    doi: 10.1097/SHK.0000000000000386PMID:26009816
  10. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. Rameseder, J, Krismer, K, Dayma, Y, Ehrenberger, T, Hwang, MK, Airoldi, EM, Floyd, SR, Yaffe, MB. 2015. J Biomol Screen 20, 985-97.
    doi: 10.1177/1087057115583037PMID:25918037
More Publications
Photo credit: Bryce Vickmark