Matthew Vander Heiden

Matthew Vander Heiden

Director, Koch Institute for Integrative Cancer Research; Lester Wolfe Professor of Molecular Biology

Matthew Vander Heiden is interested in the role that cell metabolism plays in mammalian physiology, with a focus on cancer.






Peter Jansen



Assistant Phone


  • PhD, 2000, University of Chicago; MD, 2002, University of Chicago
  • SB, 1994, Biological Chemistry, University of Chicago

Research Summary

We study the biochemical pathways cells use and how they are regulated to meet the metabolic requirements of cells in different physiological situations. We focus on the role of metabolism in cancer, particularly how metabolic pathways support cell proliferation. We aim to translate our understanding of cancer cell metabolism into novel cancer therapies.


  • Howard Hughes Medical Institute Faculty Scholar, 2016
  • SU2C Innovative Research Grant Recipient, 2016

Recent Publications

  1. GOT2 consider the tumor microenvironment. Do, BT, Vander Heiden, MG. 2022. Trends Cancer 8, 884-886.
    doi: 10.1016/j.trecan.2022.09.004PMID:36153305
  2. Nucleotide imbalance decouples cell growth from cell proliferation. Diehl, FF, Miettinen, TP, Elbashir, R, Nabel, CS, Darnell, AM, Do, BT, Manalis, SR, Lewis, CA, Vander Heiden, MG. 2022. Nat Cell Biol 24, 1252-1264.
    doi: 10.1038/s41556-022-00965-1PMID:35927450
  3. Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Davidson, SM, Schmidt, DR, Heyman, JE, O'Brien, JP, Liu, AC, Israelsen, WJ, Dayton, TL, Sehgal, R, Bronson, RT, Freinkman, E et al.. 2022. Cancer Res 82, 2403-2416.
    doi: 10.1158/0008-5472.CAN-21-2352PMID:35584006
  4. Inhibiting GLUTtony in cancer. Chang, SM, Vander Heiden, MG. 2022. Cell Chem Biol 29, 353-355.
    doi: 10.1016/j.chembiol.2022.03.004PMID:35303439
  5. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Ferraro, GB, Ali, A, Luengo, A, Kodack, DP, Deik, A, Abbott, KL, Bezwada, D, Blanc, L, Prideaux, B, Jin, X et al.. 2021. Nat Cancer 2, 1243.
    doi: 10.1038/s43018-021-00283-9PMID:35122065
  6. Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors. Datta, R, Sivanand, S, Lau, AN, Florek, LV, Barbeau, AM, Wyckoff, J, Skala, MC, Vander Heiden, MG. 2022. Sci Adv 8, eabg6383.
    doi: 10.1126/sciadv.abg6383PMID:35061540
  7. Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Sullivan, MR, Darnell, AM, Reilly, MF, Kunchok, T, Joesch-Cohen, L, Rosenberg, D, Ali, A, Rees, MG, Roth, JA, Lewis, CA et al.. 2021. Nat Metab 3, 1500-1511.
    doi: 10.1038/s42255-021-00486-5PMID:34799701
  8. Low glycaemic diets alter lipid metabolism to influence tumour growth. Lien, EC, Westermark, AM, Zhang, Y, Yuan, C, Li, Z, Lau, AN, Sapp, KM, Wolpin, BM, Vander Heiden, MG. 2021. Nature 599, 302-307.
    doi: 10.1038/s41586-021-04049-2PMID:34671163
  9. Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot? Nabel, CS, Vander Heiden, MG. 2021. Cancer Res 81, 4399-4401.
    doi: 10.1158/0008-5472.CAN-21-0770PMID:34470781
  10. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Ferraro, GB, Ali, A, Luengo, A, Kodack, DP, Deik, A, Abbott, KL, Bezwada, D, Blanc, L, Prideaux, B, Jin, X et al.. 2021. Nat Cancer 2, 414-428.
    doi: 10.1038/s43018-021-00183-yPMID:34179825
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