Matthew Vander Heiden

Matthew Vander Heiden

Director, Koch Institute for Integrative Cancer Research; Lester Wolfe Professor of Molecular Biology

Matthew Vander Heiden is interested in the role that cell metabolism plays in mammalian physiology, with a focus on cancer.






Koch Institute for Integrative Cancer Research


Peter Jansen



Assistant Phone


  • PhD, 2000, University of Chicago; MD, 2002, University of Chicago
  • SB, 1994, Biological Chemistry, University of Chicago

Research Summary

We study the biochemical pathways cells use and how they are regulated to meet the metabolic requirements of cells in different physiological situations. We focus on the role of metabolism in cancer, particularly how metabolic pathways support cell proliferation. We aim to translate our understanding of cancer cell metabolism into novel cancer therapies.


  • Howard Hughes Medical Institute Faculty Scholar, 2016
  • SU2C Innovative Research Grant Recipient, 2016

Recent Publications

  1. Screening in serum-derived medium reveals differential response to compounds targeting metabolism. Abbott, KL, Ali, A, Casalena, D, Do, BT, Ferreira, R, Cheah, JH, Soule, CK, Deik, A, Kunchok, T, Schmidt, DR et al.. 2023. Cell Chem Biol 30, 1156-1168.e7.
    doi: 10.1016/j.chembiol.2023.08.007PMID:37689063
  2. Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer. Schmidt, DR, Gramatikov, IMT, Sheen, A, Williams, CL, Hurwitz, M, Dodge, LE, Holupka, E, Kiger, WS 3rd, Cornwall-Brady, MR, Huang, W et al.. 2023. Commun Med (Lond) 3, 108.
    doi: 10.1038/s43856-023-00336-3PMID:37558833
  3. The bidirectional relationship between metabolism and cell cycle control. Diehl, FF, Sapp, KM, Vander Heiden, MG. 2023. Trends Cell Biol , .
    doi: 10.1016/j.tcb.2023.05.012PMID:37385879
  4. GOT2 consider the tumor microenvironment. Do, BT, Vander Heiden, MG. 2022. Trends Cancer 8, 884-886.
    doi: 10.1016/j.trecan.2022.09.004PMID:36153305
  5. Nucleotide imbalance decouples cell growth from cell proliferation. Diehl, FF, Miettinen, TP, Elbashir, R, Nabel, CS, Darnell, AM, Do, BT, Manalis, SR, Lewis, CA, Vander Heiden, MG. 2022. Nat Cell Biol 24, 1252-1264.
    doi: 10.1038/s41556-022-00965-1PMID:35927450
  6. Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Davidson, SM, Schmidt, DR, Heyman, JE, O'Brien, JP, Liu, AC, Israelsen, WJ, Dayton, TL, Sehgal, R, Bronson, RT, Freinkman, E et al.. 2022. Cancer Res 82, 2403-2416.
    doi: 10.1158/0008-5472.CAN-21-2352PMID:35584006
  7. Inhibiting GLUTtony in cancer. Chang, SM, Vander Heiden, MG. 2022. Cell Chem Biol 29, 353-355.
    doi: 10.1016/j.chembiol.2022.03.004PMID:35303439
  8. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Ferraro, GB, Ali, A, Luengo, A, Kodack, DP, Deik, A, Abbott, KL, Bezwada, D, Blanc, L, Prideaux, B, Jin, X et al.. 2021. Nat Cancer 2, 1243.
    doi: 10.1038/s43018-021-00283-9PMID:35122065
  9. Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors. Datta, R, Sivanand, S, Lau, AN, Florek, LV, Barbeau, AM, Wyckoff, J, Skala, MC, Vander Heiden, MG. 2022. Sci Adv 8, eabg6383.
    doi: 10.1126/sciadv.abg6383PMID:35061540
  10. Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Sullivan, MR, Darnell, AM, Reilly, MF, Kunchok, T, Joesch-Cohen, L, Rosenberg, D, Ali, A, Rees, MG, Roth, JA, Lewis, CA et al.. 2021. Nat Metab 3, 1500-1511.
    doi: 10.1038/s42255-021-00486-5PMID:34799701
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