Matthew Vander Heiden

Matthew Vander Heiden

Director, Koch Institute for Integrative Cancer Research; Lester Wolfe Professor of Molecular Biology

Matthew Vander Heiden is interested in the role that cell metabolism plays in mammalian physiology, with a focus on cancer.

617-715-4471

Phone

76-561

Office

mvh@mit.edu

Email

Koch Institute for Integrative Cancer Research

Location

Lab Website
Peter Jansen

Assistant

617-252-1163

Assistant Phone

Education

  • PhD, 2000, University of Chicago; MD, 2002, University of Chicago
  • SB, 1994, Biological Chemistry, University of Chicago

Research Summary

We study the biochemical pathways cells use and how they are regulated to meet the metabolic requirements of cells in different physiological situations. We focus on the role of metabolism in cancer, particularly how metabolic pathways support cell proliferation. We aim to translate our understanding of cancer cell metabolism into novel cancer therapies.

Awards

  • National Academy of Medicine, 2024
  • Howard Hughes Medical Institute Faculty Scholar, 2016
  • SU2C Innovative Research Grant Recipient, 2016

Recent Publications

  1. Site of breast cancer metastasis is independent of single nutrient levels. Abbott, KL, Subudhi, S, Ferreira, R, Gültekin, Y, Steinbuch, SC, Munim, MB, Honeder, SE, Kumar, AS, Ramesh, DL, Wu, M et al.. 2024. bioRxiv , .
    doi: 10.1101/2024.10.24.616714PMID:39484531
  2. Understanding the Warburg Effect in Cancer. Li, Z, Munim, MB, Sharygin, DA, Bevis, BJ, Vander Heiden, MG. 2024. Cold Spring Harb Perspect Med , .
    doi: 10.1101/cshperspect.a041532PMID:39284669
  3. Cancer tissue of origin constrains the growth and metabolism of metastases. Sivanand, S, Gultekin, Y, Winter, PS, Vermeulen, SY, Tchourine, KM, Abbott, KL, Danai, LV, Gourgue, F, Do, BT, Crowder, K et al.. 2024. Nat Metab 6, 1668-1681.
    doi: 10.1038/s42255-024-01105-9PMID:39160333
  4. Macrophages dig into the obesity paradox in cancer. Nabel, CS, Gourgue, F, Vander Heiden, MG. 2024. Immunity 57, 1731-1733.
    doi: 10.1016/j.immuni.2024.07.013PMID:39142274
  5. Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress. Do, BT, Hsu, PP, Vermeulen, SY, Wang, Z, Hirz, T, Abbott, KL, Aziz, N, Replogle, JM, Bjelosevic, S, Paolino, J et al.. 2024. Dev Cell 59, 2203-2221.e15.
    doi: 10.1016/j.devcel.2024.05.010PMID:38823395
  6. Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. Abbott, KL, Ali, A, Reinfeld, BI, Deik, A, Subudhi, S, Landis, MD, Hongo, RA, Young, KL, Kunchok, T, Nabel, CS et al.. 2024. Elife 13, .
    doi: 10.7554/eLife.95652PMID:38787918
  7. Effects of aging on glucose and lipid metabolism in mice. Lien, EC, Vu, N, Westermark, AM, Danai, LV, Lau, AN, Gültekin, Y, Kukurugya, MA, Bennett, BD, Vander Heiden, MG. 2023. bioRxiv , .
    doi: 10.1101/2023.12.17.572088PMID:38187759
  8. Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. Abbott, KL, Ali, A, Reinfeld, BI, Deik, A, Subudhi, S, Landis, MD, Hongo, RA, Young, KL, Kunchok, T, Nabel, CS et al.. 2024. bioRxiv , .
    doi: 10.1101/2023.12.24.573250PMID:38187626
  9. Screening in serum-derived medium reveals differential response to compounds targeting metabolism. Abbott, KL, Ali, A, Casalena, D, Do, BT, Ferreira, R, Cheah, JH, Soule, CK, Deik, A, Kunchok, T, Schmidt, DR et al.. 2023. Cell Chem Biol 30, 1156-1168.e7.
    doi: 10.1016/j.chembiol.2023.08.007PMID:37689063
  10. Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer. Schmidt, DR, Gramatikov, IMT, Sheen, A, Williams, CL, Hurwitz, M, Dodge, LE, Holupka, E, Kiger, WS 3rd, Cornwall-Brady, MR, Huang, W et al.. 2023. Commun Med (Lond) 3, 108.
    doi: 10.1038/s43856-023-00336-3PMID:37558833
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