Mary Gehring

Mary Gehring

Associate Professor of Biology; Member, Whitehead Institute

Mary Gehring researches epigenetic mechanisms of gene regulation in plants.

617-324-0343

Phone

WI-561C

Office

Beverly Dobson

Assistant

617-258-5214

Assistant Phone

Education

PhD 2005, University of California, Berkeley

Research Summary

We focus on plant epigenetics — that is, the heritable information that influences cellular function but is not encoded in the DNA sequence itself. We use genetic, genomic and molecular biology approaches to study the fidelity of epigenetic inheritance and the dynamics of epigenomic reprogramming during reproduction, primarily in the model plant Arabidopsis thaliana. More specifically, we investigate the interplay among repetitive sequences, DNA methylation and chromatin structure in these dynamic processes.

Awards

  • Rosalind Franklin Young Investigator Award, 2013
  • Pew Scholar in the Biomedical Sciences, 2011

Recent Publications

  1. Ten things you should know about transposable elements. Bourque, G, Burns, KH, Gehring, M, Gorbunova, V, Seluanov, A, Hammell, M, Imbeault, M, Izsvák, Z, Levin, HL, Macfarlan, TS et al.. 2018. Genome Biol. 19, 199.
    doi: 10.1186/s13059-018-1577-zPMID:30454069
  2. A variably imprinted epiallele impacts seed development. Pignatta, D, Novitzky, K, Satyaki, PRV, Gehring, M. 2018. PLoS Genet. 14, e1007469.
    doi: 10.1371/journal.pgen.1007469PMID:30395602
  3. A Small RNA Pathway Mediates Allelic Dosage in Endosperm. Erdmann, RM, Satyaki, PRV, Klosinska, M, Gehring, M. 2017. Cell Rep 21, 3364-3372.
    doi: 10.1016/j.celrep.2017.11.078PMID:29262317
  4. Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit. Williams, BP, Gehring, M. 2017. Nat Commun 8, 2124.
    doi: 10.1038/s41467-017-02219-3PMID:29242626
  5. Molecular movement in the Arabidopsis thaliana female gametophyte. Erdmann, RM, Hoffmann, A, Walter, HK, Wagenknecht, HA, Groß-Hardt, R, Gehring, M. 2017. Plant Reprod 30, 141-146.
    doi: 10.1007/s00497-017-0304-3PMID:28695277
  6. Proximal methylation features associated with nonrandom changes in gene body methylation. Picard, CL, Gehring, M. 2017. Genome Biol. 18, 73.
    doi: 10.1186/s13059-017-1206-2PMID:28446217
  7. DNA methylation and imprinting in plants: machinery and mechanisms. Satyaki, PR, Gehring, M. 2017. Crit. Rev. Biochem. Mol. Biol. 52, 163-175.
    doi: 10.1080/10409238.2017.1279119PMID:28118754
  8. Endosperm and Imprinting, Inextricably Linked. Gehring, M, Satyaki, PR. 2017. Plant Physiol. 173, 143-154.
    doi: 10.1104/pp.16.01353PMID:27895206
  9. Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Klosinska, M, Picard, CL, Gehring, M. 2016. Nat Plants 2, 16145.
    doi: 10.1038/nplants.2016.145PMID:27643534
  10. Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat. Williams, BP, Pignatta, D, Henikoff, S, Gehring, M. 2015. PLoS Genet. 11, e1005142.
    doi: 10.1371/journal.pgen.1005142PMID:25826366
More Publications

Multimedia

Photo credit: Gretchen Ertl/Whitehead Institute