Martha Constantine-Paton

Martha Constantine-Paton

Professor of Biology; Investigator, McGovern Institute

Martha Constantine-Paton uses a combination of classical and modern genetic tools in mice to study the contributions of specific brain regions to normal behavior.

617-258-6415

Phone

46-4165

Office

Beth Klein

Assistant

617-452-3080

Assistant Phone

Education

PhD 1976, Cornell University

Research Summary

We focus on the Flailer mutant mouse, which carries a brain region-specific dominant negative gene for the actin motor protein MyosinVa and shows a series of abnormal behaviors. We have designed a CRISPR-Cas9 that removes this dominant negative mutation from certain brain regions to dissect the contribution of each region to normal behavior.

Awards

  • American Academy of Arts and Sciences, Fellow, 2015
Image credit: Kent Dayton

Key Publications

  1. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Yoshii, A, Constantine-Paton, M. 2007. Nat. Neurosci. 10, 702-11.
    doi: 10.1038/nn1903PMID:17515902
  2. Microarray analysis of microRNA expression in the developing mammalian brain. Miska, EA, Alvarez-Saavedra, E, Townsend, M, Yoshii, A, Sestan, N, Rakic, P, Constantine-Paton, M, Horvitz, HR. 2004. Genome Biol. 5, R68.
    doi: 10.1186/gb-2004-5-9-r68PMID:15345052
  3. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Yoshii, A, Sheng, MH, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1334-9.
    doi: 10.1073/pnas.0335785100PMID:12552131
  4. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Townsend, M, Yoshii, A, Mishina, M, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1340-5.
    doi: 10.1073/pnas.0335786100PMID:12552130
  5. NMDA receptor-mediated control of protein synthesis at developing synapses. Scheetz, AJ, Nairn, AC, Constantine-Paton, M. 2000. Nat. Neurosci. 3, 211-6.
    doi: 10.1038/72915PMID:10700251

Recent Publications

  1. Synaptic Effects of Dopamine Breakdown and Their Relation to Schizophrenia-Linked Working Memory Deficits. Bolton, AD, Constantine-Paton, M. 2018. Front Synaptic Neurosci 10, 16.
    doi: 10.3389/fnsyn.2018.00016PMID:29950984
  2. A Diencephalic Dopamine Source Provides Input to the Superior Colliculus, where D1 and D2 Receptors Segregate to Distinct Functional Zones. Bolton, AD, Murata, Y, Kirchner, R, Kim, SY, Young, A, Dang, T, Yanagawa, Y, Constantine-Paton, M. 2015. Cell Rep 13, 1003-15.
    doi: 10.1016/j.celrep.2015.09.046PMID:26565913
  3. Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling. Yoshii, A, Constantine-Paton, M. 2014. Front Synaptic Neurosci 6, 6.
    doi: 10.3389/fnsyn.2014.00006PMID:24744726
  4. Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition. Bolton, AD, Phillips, MA, Constantine-Paton, M. 2013. J. Neurophysiol. 110, 1567-82.
    doi: 10.1152/jn.00809.2012PMID:23864370
  5. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. Yoshii, A, Zhao, JP, Pandian, S, van Zundert, B, Constantine-Paton, M. 2013. J. Neurosci. 33, 8472-82.
    doi: 10.1523/JNEUROSCI.4585-12.2013PMID:23658184
  6. Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. Murata, Y, Constantine-Paton, M. 2013. J. Neurosci. 33, 5040-52.
    doi: 10.1523/JNEUROSCI.2896-12.2013PMID:23486974
  7. Eye opening and PSD95 are required for long-term potentiation in developing superior colliculus. Zhao, JP, Murata, Y, Constantine-Paton, M. 2013. Proc. Natl. Acad. Sci. U.S.A. 110, 707-12.
    doi: 10.1073/pnas.1215854110PMID:23267080
  8. A synaptic strategy for consolidation of convergent visuotopic maps. Phillips, MA, Colonnese, MT, Goldberg, J, Lewis, LD, Brown, EN, Constantine-Paton, M. 2011. Neuron 71, 710-24.
    doi: 10.1016/j.neuron.2011.06.023PMID:21867886
  9. TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex. Yoshii, A, Murata, Y, Kim, J, Zhang, C, Shokat, KM, Constantine-Paton, M. 2011. J. Neurosci. 31, 11894-904.
    doi: 10.1523/JNEUROSCI.2190-11.2011PMID:21849550
  10. Synaptic drive at developing synapses: transient upregulation of kainate receptors. van Zundert, B, Zhao, JP, Constantine-Paton, M. 2010. Dev Neurobiol 70, 737-50.
    doi: 10.1002/dneu.20807PMID:20518018
More Publications
Photo credit: Kent Dayton