Martha Constantine-Paton

Martha Constantine-Paton

Professor of Biology; Investigator, McGovern Institute

Martha Constantine-Paton uses a combination of classical and modern genetic tools in mice to study the contributions of specific brain regions to normal behavior.





Beth Klein



Assistant Phone


PhD 1976, Cornell University

Research Summary

We focus on the Flailer mutant mouse, which carries a brain region-specific dominant negative gene for the actin motor protein MyosinVa and shows a series of abnormal behaviors. We have designed a CRISPR-Cas9 that removes this dominant negative mutation from certain brain regions to dissect the contribution of each region to normal behavior.


  • American Academy of Arts and Sciences, Fellow, 2015
Image credit: Kent Dayton

Key Publications

  1. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Yoshii, A, Constantine-Paton, M. 2007. Nat. Neurosci. 10, 702-11.
    doi: 10.1038/nn1903PMID:17515902
  2. Microarray analysis of microRNA expression in the developing mammalian brain. Miska, EA, Alvarez-Saavedra, E, Townsend, M, Yoshii, A, Sestan, N, Rakic, P, Constantine-Paton, M, Horvitz, HR. 2004. Genome Biol. 5, R68.
    doi: 10.1186/gb-2004-5-9-r68PMID:15345052
  3. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Yoshii, A, Sheng, MH, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1334-9.
    doi: 10.1073/pnas.0335785100PMID:12552131
  4. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Townsend, M, Yoshii, A, Mishina, M, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1340-5.
    doi: 10.1073/pnas.0335786100PMID:12552130
  5. NMDA receptor-mediated control of protein synthesis at developing synapses. Scheetz, AJ, Nairn, AC, Constantine-Paton, M. 2000. Nat. Neurosci. 3, 211-6.
    doi: 10.1038/72915PMID:10700251

Recent Publications

More Publications
Photo credit: Kent Dayton