Martha Constantine-Paton

Martha Constantine-Paton

Professor of Biology; Investigator, McGovern Institute

Martha Constantine-Paton uses a combination of classical and modern genetic tools in mice to study the contributions of specific brain regions to normal behavior.

617-258-6415

Phone

46-4165

Office

Beth Klein

Assistant

617-452-3080

Assistant Phone

Education

PhD 1976, Cornell University

Research Summary

We focus on the Flailer mutant mouse, which carries a brain region-specific dominant negative gene for the actin motor protein MyosinVa and shows a series of abnormal behaviors. We have designed a CRISPR-Cas9 that removes this dominant negative mutation from certain brain regions to dissect the contribution of each region to normal behavior.

Awards

  • American Academy of Arts and Sciences, Fellow, 2015
Image credit: Kent Dayton

Key Publications

  1. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Yoshii, A, Constantine-Paton, M. 2007. Nat. Neurosci. 10, 702-11.
    doi: 10.1038/nn1903PMID:17515902
  2. Microarray analysis of microRNA expression in the developing mammalian brain. Miska, EA, Alvarez-Saavedra, E, Townsend, M, Yoshii, A, Sestan, N, Rakic, P, Constantine-Paton, M, Horvitz, HR. 2004. Genome Biol. 5, R68.
    doi: 10.1186/gb-2004-5-9-r68PMID:15345052
  3. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Yoshii, A, Sheng, MH, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1334-9.
    doi: 10.1073/pnas.0335785100PMID:12552131
  4. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Townsend, M, Yoshii, A, Mishina, M, Constantine-Paton, M. 2003. Proc. Natl. Acad. Sci. U.S.A. 100, 1340-5.
    doi: 10.1073/pnas.0335786100PMID:12552130
  5. NMDA receptor-mediated control of protein synthesis at developing synapses. Scheetz, AJ, Nairn, AC, Constantine-Paton, M. 2000. Nat. Neurosci. 3, 211-6.
    doi: 10.1038/72915PMID:10700251

Recent Publications

More Publications
Photo credit: Kent Dayton