Lindsay Case

Lindsay Case

Assistant Professor (beginning January 2021)

Lindsay Case studies how molecules are concentrated and organized at the plasma membrane to regulate transmembrane signaling.

Education

  • PhD, 2014, University of North Carolina at Chapel Hill
  • BA, 2008, Biology, Franklin and Marshall College

Research Summary

We study how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling. For example, receptor clustering and higher-order assembly with cytoplasmic proteins can create compartments with unique biochemical and biophysical properties. We use quantitative experimental approaches from biochemistry, molecular biophysics, and cell biology to study transmembrane signaling pathways and how they are misregulated in diseases like cancer. Lindsay Case will begin her appointment in January 2021.

Awards

  • Damon Runyon-Dale F. Frey Breakthrough Scientist, 2020

Key Publications

  1. Regulation of Transmembrane Signaling by Phase Separation. Case, LB, Ditlev, JA, Rosen, MK. 2019. Annu Rev Biophys 48, 465-494.
    doi: 10.1146/annurev-biophys-052118-115534PMID:30951647
  2. Stoichiometry controls activity of phase-separated clusters of actin signaling proteins. Case, LB, Zhang, X, Ditlev, JA, Rosen, MK. 2019. Science 363, 1093-1097.
    doi: 10.1126/science.aau6313PMID:30846599
  3. Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. Case, LB, Waterman, CM. 2015. Nat Cell Biol 17, 955-63.
    doi: 10.1038/ncb3191PMID:26121555
  4. Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Case, LB, Baird, MA, Shtengel, G, Campbell, SL, Hess, HF, Davidson, MW, Waterman, CM. 2015. Nat Cell Biol 17, 880-92.
    doi: 10.1038/ncb3180PMID:26053221

Recent Publications

  1. Regulation of Transmembrane Signaling by Phase Separation. Case, LB, Ditlev, JA, Rosen, MK. 2019. Annu Rev Biophys 48, 465-494.
    doi: 10.1146/annurev-biophys-052118-115534PMID:30951647
  2. Stoichiometry controls activity of phase-separated clusters of actin signaling proteins. Case, LB, Zhang, X, Ditlev, JA, Rosen, MK. 2019. Science 363, 1093-1097.
    doi: 10.1126/science.aau6313PMID:30846599
  3. Who's In and Who's Out-Compositional Control of Biomolecular Condensates. Ditlev, JA, Case, LB, Rosen, MK. 2018. J Mol Biol 430, 4666-4684.
    doi: 10.1016/j.jmb.2018.08.003PMID:30099028
  4. A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization. Thompson, PM, Ramachandran, S, Case, LB, Tolbert, CE, Tandon, A, Pershad, M, Dokholyan, NV, Waterman, CM, Campbell, SL. 2017. Structure 25, 264-275.
    doi: 10.1016/j.str.2016.12.002PMID:28089450
  5. Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. Case, LB, Waterman, CM. 2015. Nat Cell Biol 17, 955-63.
    doi: 10.1038/ncb3191PMID:26121555
  6. Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Case, LB, Baird, MA, Shtengel, G, Campbell, SL, Hess, HF, Davidson, MW, Waterman, CM. 2015. Nat Cell Biol 17, 880-92.
    doi: 10.1038/ncb3180PMID:26053221
  7. Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing. Pasapera, AM, Plotnikov, SV, Fischer, RS, Case, LB, Egelhoff, TT, Waterman, CM. 2015. Curr Biol 25, 175-186.
    doi: 10.1016/j.cub.2014.11.043PMID:25544611
  8. Adhesive F-actin waves: a novel integrin-mediated adhesion complex coupled to ventral actin polymerization. Case, LB, Waterman, CM. 2011. PLoS One 6, e26631.
    doi: 10.1371/journal.pone.0026631PMID:22069459
  9. Human Myo19 is a novel myosin that associates with mitochondria. Quintero, OA, DiVito, MM, Adikes, RC, Kortan, MB, Case, LB, Lier, AJ, Panaretos, NS, Slater, SQ, Rengarajan, M, Feliu, M et al.. 2009. Curr Biol 19, 2008-13.
    doi: 10.1016/j.cub.2009.10.026PMID:19932026
More Publications
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