Education
- PhD, 2014, University of North Carolina at Chapel Hill
- BA, 2008, Biology, Franklin and Marshall College
Research Summary
We study how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling. For example, receptor clustering and higher-order assembly with cytoplasmic proteins can create compartments with unique biochemical and biophysical properties. We use quantitative experimental approaches from biochemistry, molecular biophysics, and cell biology to study transmembrane signaling pathways and how they are misregulated in diseases like cancer.Awards
- Searle Scholar, 2022
- NIH Director's New Innovator Award, 2022
- AFOSR Young Investigator Award, 2021
- Brown-Goldstein Award, 2020
- Damon Runyon-Dale F. Frey Breakthrough Scientist, 2020
Key Publications
- Regulation of Transmembrane Signaling by Phase Separation. Case, LB, Ditlev, JA, Rosen, MK. 2019. Annu Rev Biophys 48, 465-494.
doi: 10.1146/annurev-biophys-052118-115534PMID:30951647 - Stoichiometry controls activity of phase-separated clusters of actin signaling proteins. Case, LB, Zhang, X, Ditlev, JA, Rosen, MK. 2019. Science 363, 1093-1097.
doi: 10.1126/science.aau6313PMID:30846599 - Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. Case, LB, Waterman, CM. 2015. Nat Cell Biol 17, 955-63.
doi: 10.1038/ncb3191PMID:26121555 - Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Case, LB, Baird, MA, Shtengel, G, Campbell, SL, Hess, HF, Davidson, MW, Waterman, CM. 2015. Nat Cell Biol 17, 880-92.
doi: 10.1038/ncb3180PMID:26053221
Recent Publications
- Phase separation in chemical and mechanical signal transduction. Cheng, X, Case, LB. 2023. Curr Opin Cell Biol 85, 102243.
doi: 10.1016/j.ceb.2023.102243PMID:37788587 - Corrigendum: Reconstitution of phase-separated signaling clusters and actin polymerization on supported lipid bilayers. Cheng, X, Ullo, MF, Case, LB. 2023. Front Cell Dev Biol 11, 1274775.
doi: 10.3389/fcell.2023.1274775PMID:37664465 - How cells sense and integrate information from different sources. Ullo, MF, Case, LB. 2023. WIREs Mech Dis 15, e1604.
doi: 10.1002/wsbm.1604PMID:36781396 - Reconstitution of Phase-Separated Signaling Clusters and Actin Polymerization on Supported Lipid Bilayers. Cheng, X, Ullo, MF, Case, LB. 2022. Front Cell Dev Biol 10, 932483.
doi: 10.3389/fcell.2022.932483PMID:35959492 - Membranes regulate biomolecular condensates. Case, LB. 2022. Nat Cell Biol 24, 404-405.
doi: 10.1038/s41556-022-00892-1PMID:35411084 - Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation. Case, LB, De Pasquale, M, Henry, L, Rosen, MK. 2022. Elife 11, .
doi: 10.7554/eLife.72588PMID:35049497 - Regulation of Transmembrane Signaling by Phase Separation. Case, LB, Ditlev, JA, Rosen, MK. 2019. Annu Rev Biophys 48, 465-494.
doi: 10.1146/annurev-biophys-052118-115534PMID:30951647 - Stoichiometry controls activity of phase-separated clusters of actin signaling proteins. Case, LB, Zhang, X, Ditlev, JA, Rosen, MK. 2019. Science 363, 1093-1097.
doi: 10.1126/science.aau6313PMID:30846599 - Who's In and Who's Out-Compositional Control of Biomolecular Condensates. Ditlev, JA, Case, LB, Rosen, MK. 2018. J Mol Biol 430, 4666-4684.
doi: 10.1016/j.jmb.2018.08.003PMID:30099028 - A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization. Thompson, PM, Ramachandran, S, Case, LB, Tolbert, CE, Tandon, A, Pershad, M, Dokholyan, NV, Waterman, CM, Campbell, SL. 2017. Structure 25, 264-275.
doi: 10.1016/j.str.2016.12.002PMID:28089450