Education
- PhD, 2001, University of Massachusetts Medical School
- BS, 1990, Biomedical Science, Framingham State University
Research Summary
We investigate how complex circuits of genes are regulated to produce robust developmental outcomes particularly during heart development. A main focus is to determine how DNA is packaged into chromatin, and how ATP-dependent chromatin remodelers modify this packaging to control lineage commitment. We are now applying these principles to develop methods to stimulate repair of damaged cardiac tissue (e.g., regeneration). Our ability to combine genomic, genetic, biochemical, and cell biological approaches both
in vitro and
in vivo as well as ongoing efforts to use tissue engineering to model the 3D architecture of the heart will ultimately allow us to gain a systems level and quantitative understanding of the regulatory circuits that promote normal heart development and how faulty regulation can lead to disease.
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Awards
- Medicine by Design Distinguished Lecture, 2017
- Cardiovascular Rising Star Distinguished Lecture, 2017
- American Heart Association Innovative Research Award, 2013
- Irvin and Helen Sizer Career Development Award, 2012
- Smith Family Award for Excellence in Biomedical Science, 2009
- Massachusetts Life Sciences Center New Investigator Award, 2008
- Pew Scholars Award in the Biomedical Sciences, 2008
- Honorary Doctorate, Framingham State College, 2007
- The Scientific American World’s 50 Top Leaders in Research, Business or Policy, 2006
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