Education
- PhD, 2010, MIT
- BA, 2003, Computer Science, University of California, Berkeley
- BS, 2003, Biological Engineering, University of California, Berkeley
Research Summary
The Davis lab is working to uncover how cells construct and degrade complex molecular machines rapidly and efficiently. We apply a variety of biochemical, biophysical, and structural approaches including quantitative mass spectrometry and single particle cryo-electron microscopy to understand the detailed molecular mechanisms of these processes. Ongoing projects in the lab are focused on autophagy, an essential eukaryotic protein and organelle degradation pathway, and assembly of the ribosome, which is essential in all cells.Awards
- Sloan Research Fellowship, Alfred P. Sloan Foundation, 2021
- National Institute on Aging R00 Fellowship, 2017
- National Institute on Aging K99 Fellowship, 2015
Recent Publications
- An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins. Ghanbarpour, A, Telusma, B, Powell, BM, Zhang, JJ, Bolstad, I, Vargas, C, Keller, S, Baker, T, Sauer, RT, Davis, JH et al.. 2024. bioRxiv , .
doi: 10.1101/2024.08.09.604662PMID:39149393 - NCOA4 initiates ferritinophagy by binding GATE16 using two highly avid short linear interaction motifs. Lee, A, Davis, JH. 2024. bioRxiv , .
doi: 10.1101/2024.06.09.597909PMID:38895392 - Rapid structural analysis of bacterial ribosomes in situ. Powell, BM, Brant, TS, Davis, JH, Mosalaganti, S. 2024. bioRxiv , .
doi: 10.1101/2024.03.22.586148PMID:38585831 - Learning structural heterogeneity from cryo-electron sub-tomograms with tomoDRGN. Powell, BM, Davis, JH. 2024. Nat Methods 21, 1525-1536.
doi: 10.1038/s41592-024-02210-zPMID:38459385 - A proteolytic AAA+ machine poised to unfold a protein substrate. Ghanbarpour, A, Sauer, RT, Davis, JH. 2023. bioRxiv , .
doi: 10.1101/2023.12.14.571662PMID:38168193 - Application of Monolayer Graphene to Cryo-Electron Microscopy Grids for High-resolution Structure Determination. Grassetti, AV, May, MB, Davis, JH. 2023. J Vis Exp , .
doi: 10.3791/66023PMID:38009744 - A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation. Ghanbarpour, A, Cohen, SE, Fei, X, Kinman, LF, Bell, TA, Zhang, JJ, Baker, TA, Davis, JH, Sauer, RT. 2023. Nat Commun 14, 7281.
doi: 10.1038/s41467-023-43145-xPMID:37949857 - Imaging structurally dynamic ribosomes with cryogenic electron microscopy. Webster, SM, May, MB, Powell, BM, Davis, JH. 2023. ArXiv , .
PMID:37693176 - KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion. Sun, J, Kinman, LF, Jahagirdar, D, Ortega, J, Davis, JH. 2023. Nat Struct Mol Biol 30, 1468-1480.
doi: 10.1038/s41594-023-01078-5PMID:37653244 - Application of monolayer graphene to cryo-electron microscopy grids for high-resolution structure determination. Grassetti, AV, May, MB, Davis, JH. 2023. bioRxiv , .
doi: 10.1101/2023.07.28.550908PMID:37546934
Multimedia