Education
- PhD, 1971, University of California, Berkeley
- BA, 1968, Chemistry, University of Pennsylvania
Research Summary
I study ribonucleotide reductases (RNRs), which catalyze the conversion of nucleotides to deoxynucleotides and play an essential role in DNA replication and repair. I support a range of ongoing projects, including those related to the radical propagation pathway utilized by Class I RNRs, the interactions between protein subunits of Class I RNR, the regulation of RNRs, and the mechanisms behind clinical drugs. I also examine the biosynthesis, activation, and regulation of formation of the essential metallo-cofactors of RNRs in
E. coli, S. cerevisiae, and humans. JoAnne Stubbe is no longer accepting students.
Awards
- Priestley Medalist, American Chemical Society, 2020
- American Association for the Advancement of Science, Fellow, 2014
- National Science Foundation, National Medal of Science, 2008
- National Academy of Sciences, Member, 1992
- American Academy of Arts and Sciences, Fellow, 1991
- Welch Award in Chemistry 2010
- NAS Chemical Sciences Award 2010
- Pearl Meister Greengard Award 2017
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