Hazel Sive

Hazel Sive

Professor of Biology; Member, Whitehead Institute; Associate Member, Broad Institute; MacVicar Faculty Fellow

Hazel Sive studies fundamental mechanisms underlying vertebrate face and brain formation, as well as the molecular underpinnings for neurodevelopmental disorders.

617-258-8242

Phone

WI-401C

Office

Heather Ferguson

Assistant

617-258-5671

Assistant Phone

Education

PhD 1986, The Rockefeller University

Research Summary

We probe molecular mechanisms underlying vertebrate development. One focus is the Extreme Anterior Domain, a facial signaling center that also forms the mouth. We examine the brain ventricular system and ‘basal constriction’, a novel cell shape change in the brain. A major focus is on neurodevelopmental disorders, including autism spectrum disorders, intellectual disability and epilepsy, in order to define novel therapeutics.

Awards

  • MacVicar Faculty Fellow, 2015

Key Publications

  1. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon, JM, Blaker-Lee, A, Chen, X, Sive, H. 2017. Hum. Mol. Genet. 26, 3699-3712.
    doi: 10.1093/hmg/ddx255PMID:28934389
  2. Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling. Jacox, L, Chen, J, Rothman, A, Lathrop-Marshall, H, Sive, H. 2016. Cell Rep 16, 1445-1455.
    doi: 10.1016/j.celrep.2016.06.073PMID:27425611
  3. Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish. Fame, RM, Chang, JT, Hong, A, Aponte-Santiago, NA, Sive, H. 2016. Fluids Barriers CNS 13, 11.
    doi: 10.1186/s12987-016-0036-zPMID:27329482
  4. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Chang, JT, Lehtinen, MK, Sive, H. 2016. Dev Neurobiol 76, 75-92.
    doi: 10.1002/dneu.22300PMID:25980532
  5. The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Jacox, L, Sindelka, R, Chen, J, Rothman, A, Dickinson, A, Sive, H. 2014. Cell Rep 8, 596-609.
    doi: 10.1016/j.celrep.2014.06.026PMID:25043181

Recent Publications

  1. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon, JM, Blaker-Lee, A, Chen, X, Sive, H. 2017. Hum. Mol. Genet. 26, 3699-3712.
    doi: 10.1093/hmg/ddx255PMID:28934389
  2. Mouth development. Chen, J, Jacox, LA, Saldanha, F, Sive, H. 2017. Wiley Interdiscip Rev Dev Biol 6, .
    doi: 10.1002/wdev.275PMID:28514120
  3. Validation of Protein Knockout in Mutant Zebrafish Lines Using In Vitro Translation Assays. Carter, BS, Cortés-Campos, C, Chen, X, McCammon, JM, Sive, HL. 2017. Zebrafish 14, 73-76.
    doi: 10.1089/zeb.2016.1326PMID:27548568
  4. Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling. Jacox, L, Chen, J, Rothman, A, Lathrop-Marshall, H, Sive, H. 2016. Cell Rep 16, 1445-1455.
    doi: 10.1016/j.celrep.2016.06.073PMID:27425611
  5. Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish. Fame, RM, Chang, JT, Hong, A, Aponte-Santiago, NA, Sive, H. 2016. Fluids Barriers CNS 13, 11.
    doi: 10.1186/s12987-016-0036-zPMID:27329482
  6. Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish. McCammon, JM, Sive, H. 2015. Dis Model Mech 8, 647-56.
    doi: 10.1242/dmm.019620PMID:26092527
  7. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Chang, JT, Lehtinen, MK, Sive, H. 2016. Dev Neurobiol 76, 75-92.
    doi: 10.1002/dneu.22300PMID:25980532
  8. The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Jacox, L, Sindelka, R, Chen, J, Rothman, A, Dickinson, A, Sive, H. 2014. Cell Rep 8, 596-609.
    doi: 10.1016/j.celrep.2014.06.026PMID:25043181
  9. Facial transplants in Xenopus laevis embryos. Jacox, LA, Dickinson, AJ, Sive, H. 2014. J Vis Exp , .
    doi: 10.3791/50697PMID:24748020
  10. Manual drainage of the zebrafish embryonic brain ventricles. Chang, JT, Sive, H. 2012. J Vis Exp , e4243.
    doi: 10.3791/4243PMID:23271011
More Publications

Multimedia

Photo credit: Gretchen Ertl/Whitehead Institute