Hazel Sive

Hazel Sive

Professor Emerita; Dean of Science, Northeastern University

At MIT and continuing at Northeastern University, Hazel Sive studies fundamental mechanisms underlying vertebrate face and brain formation, as well as the molecular underpinnings for neurodevelopmental disorders.

617-258-8242

Phone

WI-401C

Office

sive@wi.mit.edu

Email

Lab Website
Heather Ferguson

Assistant

617-258-5671

Assistant Phone

Education

  • PhD, 1986, The Rockefeller University
  • BS, 1976, Chemistry and Zoology, University of Witwatersrand, Johannesburg, S.A.

Research Summary

The Sive lab probes molecular mechanisms underlying vertebrate development. They focus on the Extreme Anterior Domain, a facial signaling center that also forms the mouth. They examine the brain ventricular system and ‘basal constriction’, a novel cell shape change in the brain. They also focus on neurodevelopmental disorders, including autism spectrum disorders, intellectual disability, and epilepsy, in order to define novel therapeutics. In June 2020, Professor Sive moved to become Dean of Science and Professor of Biology at Northeastern University. She is actively accepting postdoctoral fellows into her lab.

Awards

  • School of Science Teaching Prize, 2020
  • Margaret MacVicar Faculty Fellow, 2015 - 2025

Key Publications

  1. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon, JM, Blaker-Lee, A, Chen, X, Sive, H. 2017. Hum Mol Genet 26, 3699-3712.
    doi: 10.1093/hmg/ddx255PMID:28934389
  2. Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling. Jacox, L, Chen, J, Rothman, A, Lathrop-Marshall, H, Sive, H. 2016. Cell Rep 16, 1445-1455.
    doi: 10.1016/j.celrep.2016.06.073PMID:27425611
  3. Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish. Fame, RM, Chang, JT, Hong, A, Aponte-Santiago, NA, Sive, H. 2016. Fluids Barriers CNS 13, 11.
    doi: 10.1186/s12987-016-0036-zPMID:27329482
  4. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Chang, JT, Lehtinen, MK, Sive, H. 2016. Dev Neurobiol 76, 75-92.
    doi: 10.1002/dneu.22300PMID:25980532
  5. The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Jacox, L, Sindelka, R, Chen, J, Rothman, A, Dickinson, A, Sive, H. 2014. Cell Rep 8, 596-609.
    doi: 10.1016/j.celrep.2014.06.026PMID:25043181

Recent Publications

  1. 16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis. Tomasello, DL, Kim, JL, Khodour, Y, McCammon, JM, Mitalipova, M, Jaenisch, R, Futerman, AH, Sive, H. 2022. iScience 25, 103551.
    doi: 10.1016/j.isci.2021.103551PMID:34984324
  2. Noninvasive Multielectrode Array for Brain and Spinal Cord Local Field Potential Recordings from Live Zebrafish Larvae. Tomasello, DL, Sive, H. 2020. Zebrafish 17, 271-277.
    doi: 10.1089/zeb.2020.1874PMID:32758083
  3. Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube: A Primer with Latest Insights. Fame, RM, Cortés-Campos, C, Sive, HL. 2020. Bioessays 42, e1900186.
    doi: 10.1002/bies.201900186PMID:32078177
  4. Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Gutzman, JH, Graeden, E, Brachmann, I, Yamazoe, S, Chen, JK, Sive, H. 2018. Biol Open 7, .
    doi: 10.1242/bio.034520PMID:30305282
  5. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon, JM, Blaker-Lee, A, Chen, X, Sive, H. 2017. Hum Mol Genet 26, 3699-3712.
    doi: 10.1093/hmg/ddx255PMID:28934389
  6. Mouth development. Chen, J, Jacox, LA, Saldanha, F, Sive, H. 2017. Wiley Interdiscip Rev Dev Biol 6, .
    doi: 10.1002/wdev.275PMID:28514120
  7. Validation of Protein Knockout in Mutant Zebrafish Lines Using In Vitro Translation Assays. Carter, BS, Cortés-Campos, C, Chen, X, McCammon, JM, Sive, HL. 2017. Zebrafish 14, 73-76.
    doi: 10.1089/zeb.2016.1326PMID:27548568
  8. Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling. Jacox, L, Chen, J, Rothman, A, Lathrop-Marshall, H, Sive, H. 2016. Cell Rep 16, 1445-1455.
    doi: 10.1016/j.celrep.2016.06.073PMID:27425611
  9. Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish. Fame, RM, Chang, JT, Hong, A, Aponte-Santiago, NA, Sive, H. 2016. Fluids Barriers CNS 13, 11.
    doi: 10.1186/s12987-016-0036-zPMID:27329482
  10. Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish. McCammon, JM, Sive, H. 2015. Dis Model Mech 8, 647-56.
    doi: 10.1242/dmm.019620PMID:26092527
More Publications

Multimedia

Photo credit: Gretchen Ertl/Whitehead Institute