Education
- PhD, 2016, University of Toronto
- BSc, 2010, Biochemistry, McMaster University
Research Summary
Immune cells communicate across multiple scales in time and space, forming intercellular circuits that promote or impede the immune response. We employ distinct quantitative fluorescence microscopy methods, computational modeling, and experimental perturbations to study these circuits and their emergent behaviors within intact tissue environments. Ultimately, we seek to understand how imbalanced immune cell communication — due to genetic or environmental variation — results in detrimental host outcomes, including pathogen dissemination, autoimmunity, and tumorigenesis. Harikesh S. Wong will begin his appointment in early 2022.Key Publications
- T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk. Simeonov, D.R., Wong, H.S., Cortez, J.T., Young, A., Li, Z., Park, K., Umhoefer, J., Indart, A.C., Woo, J.M., Anderson, M.S., Germain, R.N., Marson, A. 2020. bioRxiv.
doi: https://doi.org/10.1101/2020.07.22.216564
Recent Publications
- Author Correction: Commensal-driven immune zonation of the liver promotes host defence. Gola, A, Dorrington, MG, Speranza, E, Sala, C, Shih, RM, Radtke, AJ, Wong, HS, Baptista, AP, Hernandez, JM, Castellani, G et al.. 2022. Nature 611, E7.
doi: 10.1038/s41586-022-05462-xPMID:36280745 - Mesoscale T cell antigen discrimination emerges from intercellular feedback. Wong, HS, Germain, RN. 2021. Trends Immunol 42, 865-875.
doi: 10.1016/j.it.2021.08.006PMID:34493455 - Author Correction: Commensal-driven immune zonation of the liver promotes host defence. Gola, A, Dorrington, MG, Speranza, E, Sala, C, Shih, RM, Radtke, AJ, Wong, HS, Baptista, AP, Hernandez, JM, Castellani, G et al.. 2021. Nature 597, E1.
doi: 10.1038/s41586-021-03346-0PMID:34373651 - A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Wong, HS, Park, K, Gola, A, Baptista, AP, Miller, CH, Deep, D, Lou, M, Boyd, LF, Rudensky, AY, Savage, PA et al.. 2021. Cell 184, 3981-3997.e22.
doi: 10.1016/j.cell.2021.05.028PMID:34157301 - Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. Russler-Germain, EV, Yi, J, Young, S, Nutsch, K, Wong, HS, Ai, TL, Chai, JN, Durai, V, Kaplan, DH, Germain, RN et al.. 2021. Elife 10, .
doi: 10.7554/eLife.54792PMID:33533717 - Commensal-driven immune zonation of the liver promotes host defence. Gola, A, Dorrington, MG, Speranza, E, Sala, C, Shih, RM, Radtke, AJ, Wong, HS, Baptista, AP, Hernandez, JM, Castellani, G et al.. 2021. Nature 589, 131-136.
doi: 10.1038/s41586-020-2977-2PMID:33239787 - Robust control of the adaptive immune system. Wong, HS, Germain, RN. 2018. Semin Immunol 36, 17-27.
doi: 10.1016/j.smim.2017.12.009PMID:29290544 - Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation. Wong, HS, Jaumouillé, V, Freeman, SA, Doodnauth, SA, Schlam, D, Canton, J, Mukovozov, IM, Saric, A, Grinstein, S, Robinson, LA et al.. 2016. Cell Rep 14, 2859-71.
doi: 10.1016/j.celrep.2016.02.071PMID:26997267 - Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Freeman, SA, Jaumouillé, V, Choi, K, Hsu, BE, Wong, HS, Abraham, L, Graves, ML, Coombs, D, Roskelley, CD, Das, R et al.. 2015. Nat Commun 6, 7015.
doi: 10.1038/ncomms8015PMID:25881569 - Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Freeman, SA, Jaumouillé, V, Choi, K, Hsu, BE, Wong, HS, Abraham, L, Graves, ML, Coombs, D, Roskelley, CD, Das, R et al.. 2015. Nat Commun 6, 6168.
doi: 10.1038/ncomms7168PMID:25644899