Gerald R. Fink

Gerald R. Fink

Margaret and Herman Sokol Professor; American Cancer Society Professor of Genetics; Member, Whitehead Institute

Gerald R. Fink investigates how fungal pathogens invade the body, evade the immune system, and establish an infection.

617-258-5215

Phone

WI-561F

Office

Beverly Dobson

Assistant

617-258-5214

Assistant Phone

Education

PhD 1965, Yale University

Research Summary

We study the molecules that allow fungi to penetrate tissues and grow in a hostile environment. Using genetics, biochemistry and genomics, we answer questions such as:  What makes Candida albicans such a successful pathogen?  How do fungal pathogens evolve antibiotic resistance? How do they manage to change their genetic composition so rapidly?

Awards

  • Killian Jr. Faculty Achievement Award, 2018
  • American Association for the Advancement of Science, Fellow, 2015
  • Gruber International Prize in Genetics, 2010
  • American Philosophical Society, 2003
  • Yeast Genetics and Molecular Biology – Lifetime Achievement Award, 2002
  • George W. Beadle Award, Genetics Society of America, 2001
  • Ellison Medical Foundation, Senior Scholar Award, 2001
  • National Academy of Medicine, 1996
  • Wilbur Lucius Cross Medal, Yale University, 1992
  • Emil Christian Hansen Foundation Award for Microbiology, Denmark, 1986
  • American Academy of Arts and Sciences, Fellow, 1984
  • Yale Science and Engineering Award, 1984
  • National Academy of Sciences, Member, 1981
  • National Academy of Sciences Award in Molecular Biology, 1981
  • John Simon Guggenheim Memorial Foundation, Guggenheim Fellowship, 1974

Key Publications

  1. Yeast: an experimental organism for 21st Century biology. Botstein, D, Fink, GR. 2011. Genetics 189, 695-704.
    doi: 10.1534/genetics.111.130765PMID:22084421
  2. Intragenic tandem repeats generate functional variability. Verstrepen, KJ, Jansen, A, Lewitter, F, Fink, GR. 2005. Nat. Genet. 37, 986-90.
    doi: 10.1038/ng1618PMID:16086015
  3. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Gimeno, CJ, Ljungdahl, PO, Styles, CA, Fink, GR. 1992. Cell 68, 1077-90.
    PMID:1547504
  4. Ty elements transpose through an RNA intermediate. Boeke, JD, Garfinkel, DJ, Styles, CA, Fink, GR. 1985. Cell 40, 491-500.
    PMID:2982495
  5. Transformation of yeast. Hinnen, A, Hicks, JB, Fink, GR. 1978. Proc. Natl. Acad. Sci. U.S.A. 75, 1929-33.
    PMID:347451
  6. Barbara McClintock (1902-1992). Fink, G.R. 1992. Nature 359, 272.

Recent Publications

  1. New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi. Vyas, VK, Bushkin, GG, Bernstein, DA, Getz, MA, Sewastianik, M, Barrasa, MI, Bartel, DP, Fink, GR. 2018. mSphere 3, .
    doi: 10.1128/mSphere.00154-18PMID:29695624
  2. A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families. Vyas, VK, Barrasa, MI, Fink, GR. Sci Adv 1, e1500248.
    doi: 10.1126/sciadv.1500248PMID:25977940
  3. Interactions between chromosomal and nonchromosomal elements reveal missing heritability. Edwards, MD, Symbor-Nagrabska, A, Dollard, L, Gifford, DK, Fink, GR. 2014. Proc. Natl. Acad. Sci. U.S.A. 111, 7719-22.
    doi: 10.1073/pnas.1407126111PMID:24825890
  4. Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Chin, BL, Ryan, O, Lewitter, F, Boone, C, Fink, GR. 2012. Genetics 192, 1523-32.
    doi: 10.1534/genetics.112.145573PMID:23051644
  5. Control of transcription by cell size. Wu, CY, Rolfe, PA, Gifford, DK, Fink, GR. 2010. PLoS Biol. 8, e1000523.
    doi: 10.1371/journal.pbio.1000523PMID:21072241
  6. Feed-forward regulation of a cell fate determinant by an RNA-binding protein generates asymmetry in yeast. Wolf, JJ, Dowell, RD, Mahony, S, Rabani, M, Gifford, DK, Fink, GR. 2010. Genetics 185, 513-22.
    doi: 10.1534/genetics.110.113944PMID:20382833
  7. Getting along with a little help from my friends. Fink, GR. 2009. J. Biol. Chem. 284, 23885-90.
    doi: 10.1074/jbc.X109.029389PMID:19515841
  8. Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component. Rubin-Bejerano, I, Abeijon, C, Magnelli, P, Grisafi, P, Fink, GR. 2007. Cell Host Microbe 2, 55-67.
    doi: 10.1016/j.chom.2007.06.002PMID:18005717
  9. Antisense transcription controls cell fate in Saccharomyces cerevisiae. Hongay, CF, Grisafi, PL, Galitski, T, Fink, GR. 2006. Cell 127, 735-45.
    doi: 10.1016/j.cell.2006.09.038PMID:17110333
  10. Intragenic tandem repeats generate functional variability. Verstrepen, KJ, Jansen, A, Lewitter, F, Fink, GR. 2005. Nat. Genet. 37, 986-90.
    doi: 10.1038/ng1618PMID:16086015
More Publications

Multimedia

Photo credit: Gretchen Ertl/Whitehead Institute