Education
PhD 2010, Harvard UniversityResearch Summary
Our goals are to derive a set of general principles governing the composition of the proteome, and to elucidate the mechanisms that govern precise protein levels. At the systems level, we want to understand the rationales, if they exist, for the protein expression levels that are observed in nature, and the consequences of proteome dysregulation and imbalance. At the mechanistic level, we want to uncover the molecular events that ensure optimal protein production despite the constant thermal fluctuations in living systems.Awards
- Pew Biomedical Scholar, 2017
- Smith Family Award for Excellence in Biomedical Research, 2017
- NIGMS R35 Maximizing Investigator Research Award, 2017
- Sloan Research Fellowship, 2016
- Searle Scholar, 2016
Key Publications
- Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex in Bacillus subtilis. DeLoughery, A, Lalanne, JB, Losick, R, Li, GW. 2018. Proc. Natl. Acad. Sci. U.S.A. 115, E5585-E5594.
doi: 10.1073/pnas.1803283115PMID:29794222 - Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry. Lalanne, JB, Taggart, JC, Guo, MS, Herzel, L, Schieler, A, Li, GW. 2018. Cell 173, 749-761.e38.
doi: 10.1016/j.cell.2018.03.007PMID:29606352 - Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Li, GW, Burkhardt, D, Gross, C, Weissman, JS. 2014. Cell 157, 624-35.
doi: 10.1016/j.cell.2014.02.033PMID:24766808 - The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Li, GW, Oh, E, Weissman, JS. 2012. Nature 484, 538-41.
doi: 10.1038/nature10965PMID:22456704 - Central dogma at the single-molecule level in living cells. Li, GW, Xie, XS. 2011. Nature 475, 308-15.
doi: 10.1038/nature10315PMID:21776076